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    Results: 1 to 20 of 246

    1.

    The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man.

    Krebs M, Brunmair B, Brehm A, Artwohl M, Szendroedi J, Nowotny P, Roth E, Fürnsinn C, Promintzer M, Anderwald C, Bischof M, Roden M.

    Diabetes. 2007 Jun;56(6):1600-7. Epub 2007 Feb 28.PMID: 17329620 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability.

    Tremblay F, Krebs M, Dombrowski L, Brehm A, Bernroider E, Roth E, Nowotny P, Waldhäusl W, Marette A, Roden M.

    Diabetes. 2005 Sep;54(9):2674-84.PMID: 16123357 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Acetaldehyde promotes rapamycin-dependent activation of p70(S6K) and glucose uptake despite inhibition of Akt and mTOR in dopaminergic SH-SY5Y human neuroblastoma cells.

    Fang CX, Yang X, Sreejayan N, Ren J.

    Exp Neurol. 2007 Jan;203(1):196-204. Epub 2006 Sep 7.PMID: 16962100 [PubMed - indexed for MEDLINE]Related articles

    4.

    Unlike insulin, amino acids stimulate p70S6K but not GSK-3 or glycogen synthase in human skeletal muscle.

    Liu Z, Wu Y, Nicklas EW, Jahn LA, Price WJ, Barrett EJ.

    Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E523-8. Epub 2003 Dec 2.PMID: 14656717 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men.

    Adegoke OA, Chevalier S, Morais JA, Gougeon R, Kimball SR, Jefferson LS, Wing SS, Marliss EB.

    Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E105-13. Epub 2008 Oct 28.PMID: 18957614 [PubMed - indexed for MEDLINE]Related articles

    6.

    Effects of rapamycin on cell proliferation and phosphorylation of mTOR and p70(S6K) in HepG2 and HepG2 cells overexpressing constitutively active Akt/PKB.

    Varma S, Khandelwal RL.

    Biochim Biophys Acta. 2007 Jan;1770(1):71-8. Epub 2006 Aug 1.PMID: 16952420 [PubMed - indexed for MEDLINE]Related articles

    7.

    The effects of amino acids on glucose metabolism of isolated rat skeletal muscle are independent of insulin and the mTOR/S6K pathway.

    Stadlbauer K, Brunmair B, Szöcs Z, Krebs M, Luger A, Fürnsinn C.

    Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E785-92. Epub 2009 Jul 21.PMID: 19622787 [PubMed - indexed for MEDLINE]Related articles

    8.

    Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation.

    Sipula IJ, Brown NF, Perdomo G.

    Metabolism. 2006 Dec;55(12):1637-44.PMID: 17142137 [PubMed - indexed for MEDLINE]Related articles

    9.

    In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids.

    Mothe-Satney I, Gautier N, Hinault C, Lawrence JC Jr, Van Obberghen E.

    J Biol Chem. 2004 Oct 8;279(41):42628-37. Epub 2004 Aug 2.PMID: 15292249 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover.

    Mieulet V, Roceri M, Espeillac C, Sotiropoulos A, Ohanna M, Oorschot V, Klumperman J, Sandri M, Pende M.

    Am J Physiol Cell Physiol. 2007 Aug;293(2):C712-22. Epub 2007 May 9.PMID: 17494629 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Effects of free fatty acids and glycerol on splanchnic glucose metabolism and insulin extraction in nondiabetic humans.

    Shah P, Vella A, Basu A, Basu R, Adkins A, Schwenk WF, Johnson CM, Nair KS, Jensen MD, Rizza RA.

    Diabetes. 2002 Feb;51(2):301-10.PMID: 11812736 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway.

    Ueno M, Carvalheira JB, Tambascia RC, Bezerra RM, Amaral ME, Carneiro EM, Folli F, Franchini KG, Saad MJ.

    Diabetologia. 2005 Mar;48(3):506-18. Epub 2005 Feb 4.PMID: 15692808 [PubMed - indexed for MEDLINE]Related articles

    13.

    Zinc stimulates the activity of the insulin- and nutrient-regulated protein kinase mTOR.

    Lynch CJ, Patson BJ, Goodman SA, Trapolsi D, Kimball SR.

    Am J Physiol Endocrinol Metab. 2001 Jul;281(1):E25-34.PMID: 11404220 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Effect of glucagon-like peptide-1(7-36)-amide on initial splanchnic glucose uptake and insulin action in humans with type 1 diabetes.

    Vella A, Shah P, Basu R, Basu A, Camilleri M, Schwenk FW, Holst JJ, Rizza RA.

    Diabetes. 2001 Mar;50(3):565-72.PMID: 11246876 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes.

    Kanazawa T, Taneike I, Akaishi R, Yoshizawa F, Furuya N, Fujimura S, Kadowaki M.

    J Biol Chem. 2004 Feb 27;279(9):8452-9. Epub 2003 Nov 10.PMID: 14610086 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Mechanism of amino acid-induced skeletal muscle insulin resistance in humans.

    Krebs M, Krssak M, Bernroider E, Anderwald C, Brehm A, Meyerspeer M, Nowotny P, Roth E, Waldhäusl W, Roden M.

    Diabetes. 2002 Mar;51(3):599-605.PMID: 11872656 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Vanadate and rapamycin synergistically enhance insulin-stimulated glucose uptake.

    O'Connor JC, Freund GG.

    Metabolism. 2003 Jun;52(6):666-74.PMID: 12800089 [PubMed - indexed for MEDLINE]Related articles

    18.

    Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.

    Briaud I, Dickson LM, Lingohr MK, McCuaig JF, Lawrence JC, Rhodes CJ.

    J Biol Chem. 2005 Jan 21;280(3):2282-93. Epub 2004 Nov 9.PMID: 15537654 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Elevated free fatty acids impair glucose metabolism in women: decreased stimulation of muscle glucose uptake and suppression of splanchnic glucose production during combined hyperinsulinemia and hyperglycemia.

    Shah P, Vella A, Basu A, Basu R, Adkins A, Schwenk WF, Johnson CM, Nair KS, Jensen MD, Rizza RA.

    Diabetes. 2003 Jan;52(1):38-42.PMID: 12502491 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Mechanical stimuli and nutrients regulate rapamycin-sensitive signaling through distinct mechanisms in skeletal muscle.

    Hornberger TA, Chien S.

    J Cell Biochem. 2006 Apr 15;97(6):1207-16.PMID: 16315321 [PubMed - indexed for MEDLINE]Related articles

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