PubMed

Evaluation of polymorphic splicing in the mechanism of the association of the insulin gene with diabetes.

Marchand L, Polychronakos C.

Diabetes. 2007 Mar;56(3):709-13.PMID: 17327440 [PubMed - indexed for MEDLINE]Related articlesFree article

Divergence between genetic determinants of IGF2 transcription levels in leukocytes and of IDDM2-encoded susceptibility to type 1 diabetes.

Vafiadis P, Bennett ST, Todd JA, Grabs R, Polychronakos C.

J Clin Endocrinol Metab. 1998 Aug;83(8):2933-9.PMID: 9709972 [PubMed - indexed for MEDLINE]Related articlesFree article

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

Pugliese A, Zeller M, Fernandez A Jr, Zalcberg LJ, Bartlett RJ, Ricordi C, Pietropaolo M, Eisenbarth GS, Bennett ST, Patel DD.

Nat Genet. 1997 Mar;15(3):293-7.PMID: 9054945 [PubMed - indexed for MEDLINE]Related articles

Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes.

Vafiadis P, Ounissi-Benkalha H, Palumbo M, Grabs R, Rousseau M, Goodyer CG, Polychronakos C.

J Clin Endocrinol Metab. 2001 Aug;86(8):3705-10.PMID: 11502799 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, Goodyer CG, Wickramasinghe S, Colle E, Polychronakos C.

Nat Genet. 1997 Mar;15(3):289-92.PMID: 9054944 [PubMed - indexed for MEDLINE]Related articles

Imprinted and genotype-specific expression of genes at the IDDM2 locus in pancreas and leucocytes.

Vafiadis P, Bennett ST, Colle E, Grabs R, Goodyer CG, Polychronakos C.

J Autoimmun. 1996 Jun;9(3):397-403.PMID: 8816977 [PubMed - indexed for MEDLINE]Related articles

A functional analysis of the role of IGF2 in IDDM2-encoded susceptibility to type 1 diabetes.

Vafiadis P, Grabs R, Goodyer CG, Colle E, Polychronakos C.

Diabetes. 1998 May;47(5):831-6.PMID: 9588457 [PubMed - indexed for MEDLINE]Related articlesFree article

Variants in the human insulin gene that affect pre-mRNA splicing: is -23HphI a functional single nucleotide polymorphism at IDDM2?

Královicová J, Gaunt TR, Rodriguez S, Wood PJ, Day IN, Vorechovsky I.

Diabetes. 2006 Jan;55(1):260-4.PMID: 16380501 [PubMed - indexed for MEDLINE]Related articlesFree article

Remapping the insulin gene/IDDM2 locus in type 1 diabetes.

Barratt BJ, Payne F, Lowe CE, Hermann R, Healy BC, Harold D, Concannon P, Gharani N, McCarthy MI, Olavesen MG, McCormack R, Guja C, Ionescu-Tîrgovişte C, Undlien DE, Rønningen KS, Gillespie KM, Tuomilehto-Wolf E, Tuomilehto J, Bennett ST, Clayton DG, Cordell HJ, Todd JA.

Diabetes. 2004 Jul;53(7):1884-9.PMID: 15220214 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on autoimmunity.

Tait KF, Collins JE, Heward JM, Eaves I, Snook H, Franklyn JA, Barnett AH, Todd JA, Maranian M, Compston A, Sawcer S, Gough SC.

Diabet Med. 2004 Mar;21(3):267-70.PMID: 15008838 [PubMed - indexed for MEDLINE]Related articles

IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.

Bennett ST, Wilson AJ, Cucca F, Nerup J, Pociot F, McKinney PA, Barnett AH, Bain SC, Todd JA.

J Autoimmun. 1996 Jun;9(3):415-21.PMID: 8816980 [PubMed - indexed for MEDLINE]Related articles

The INS 5' variable number of tandem repeats is associated with IGF2 expression in humans.

Paquette J, Giannoukakis N, Polychronakos C, Vafiadis P, Deal C.

J Biol Chem. 1998 Jun 5;273(23):14158-64.PMID: 9603916 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin gene/IDDM2 locus in Japanese type 1 diabetes: contribution of class I alleles and influence of class I subdivision in susceptibility to type 1 diabetes.

Awata T, Kawasaki E, Ikegami H, Kobayashi T, Maruyama T, Nakanishi K, Shimada A, Iizuka H, Kurihara S, Osaki M, Uga M, Kawabata Y, Tanaka S, Kanazawa Y, Katayama S.

J Clin Endocrinol Metab. 2007 May;92(5):1791-5. Epub 2007 Mar 6.PMID: 17341563 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes susceptibility at IDDM2 cannot be positively mapped to the VNTR locus of the insulin gene.

Doria A, Lee J, Warram JH, Krolewski AS.

Diabetologia. 1996 May;39(5):594-9.PMID: 8739920 [PubMed - indexed for MEDLINE]Related articles

Insulin gene region contributes to genetic susceptibility to, but may not to low incidence of, insulin-dependent diabetes mellitus in Japanese.

Kawaguchi Y, Ikegami H, Shen GQ, Nakagawa Y, Fujisawa T, Hamada Y, Ueda H, Fu J, Uchigata Y, Kitagawa Y, Omori Y, Shima K, Ogihara T.

Biochem Biophys Res Commun. 1997 Apr 7;233(1):283-7.PMID: 9144439 [PubMed - indexed for MEDLINE]Related articles

HLA DRB1, DQB1 and insulin promoter VNTR polymorphisms: interactions and the association with adult-onset diabetes mellitus in Czech patients.

Cejkova P, Novota P, Cerna M, Kolostova K, Novakova D, Kucera P, Novak J, Andel M, Weber P, Zdarsky E.

Int J Immunogenet. 2008 Apr;35(2):133-40. Epub 2008 Feb 11.PMID: 18279373 [PubMed - indexed for MEDLINE]Related articles

Anomalous behaviour of the 5' insulin gene polymorphism allele 814: lack of association with Type I diabetes in Basques. GEPV-N Group. Basque-Navarre Endocrinology and Paediatrics.

Urrutia I, Calvo B, Bilbao JR, Castaño L.

Diabetologia. 1998 Sep;41(9):1121-3.PMID: 9754833 [PubMed - indexed for MEDLINE]Related articles

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus.

Bennett ST, Lucassen AM, Gough SC, Powell EE, Undlien DE, Pritchard LE, Merriman ME, Kawaguchi Y, Dronsfield MJ, Pociot F, et al.

Nat Genet. 1995 Mar;9(3):284-92.PMID: 7773291 [PubMed - indexed for MEDLINE]Related articles

The insulin gene region and susceptibility to insulin-dependent diabetes mellitus in four races; new insights from Afro-Caribbean race-specific haplotypes.

Mijovic CH, Penny MA, Jenkins D, Jacobs K, Heward J, Knight SW, Lucassen A, Morrison E, Barnett AH.

Autoimmunity. 1997;26(1):11-22.PMID: 9556351 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of genetic susceptibility to type I diabetes: beyond HLA.

Anjos S, Polychronakos C.

Mol Genet Metab. 2004 Mar;81(3):187-95. Review.PMID: 14972324 [PubMed - indexed for MEDLINE]Related articles