PubMed

Patients with chronic pancreatitis have islet progenitor cells in their ducts, but reversal of overt diabetes in NOD mice by anti-CD3 shows no evidence for islet regeneration.

Phillips JM, O'Reilly L, Bland C, Foulis AK, Cooke A.

Diabetes. 2007 Mar;56(3):634-40.PMID: 17327430 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells.

Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, Tsai S, Santamaria P, Bluestone JA, Brillantes AM, Herold KC.

Endocrinology. 2007 Nov;148(11):5136-44. Epub 2007 Aug 2.PMID: 17673522 [PubMed - indexed for MEDLINE]Related articlesFree article

Remission and pancreas isograft survival in recent onset diabetic NOD mice after treatment with low-dose anti-CD3 monoclonal antibodies.

Mottram PL, Murray-Segal LJ, Han W, Maguire J, Stein-Oakley AN.

Transpl Immunol. 2002 Jun;10(1):63-72.PMID: 12182467 [PubMed - indexed for MEDLINE]Related articles

Nondepleting anti-CD4 and soluble interleukin-1 receptor prevent autoimmune destruction of syngeneic islet grafts in diabetic NOD mice.

Drage M, Zaccone P, Phillips JM, Nicoletti F, Dawson J, Andrew Bradley J, Cooke A.

Transplantation. 2002 Sep 15;74(5):611-9.PMID: 12352875 [PubMed - indexed for MEDLINE]Related articles

Remission of type 1 diabetes after anti-CD3 antibody treatment and transplantation of embryonic pancreatic precursors.

Begum S, Chen W, Herold KC, Papaioannou VE.

Endocrinology. 2009 Oct;150(10):4512-20. Epub 2009 Jul 9.PMID: 19589867 [PubMed - indexed for MEDLINE]Related articles

Evidence of primary beta-cell destruction by T-cells and beta-cell differentiation from pancreatic ductal cells in diabetes associated with active autoimmune chronic pancreatitis.

Tanaka S, Kobayashi T, Nakanishi K, Okubo M, Murase T, Hashimoto M, Watanabe G, Matsushita H, Endo Y, Yoshizaki H, Kosuge T, Sakamoto M, Takeuchi K.

Diabetes Care. 2001 Sep;24(9):1661-7.PMID: 11522716 [PubMed - indexed for MEDLINE]Related articlesFree article

Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan.

Waguri M, Yamamoto K, Miyagawa JI, Tochino Y, Yamamori K, Kajimoto Y, Nakajima H, Watada H, Yoshiuchi I, Itoh N, Imagawa A, Namba M, Kuwajima M, Yamasaki Y, Hanafusa T, Matsuzawa Y.

Diabetes. 1997 Aug;46(8):1281-90.PMID: 9231652 [PubMed - indexed for MEDLINE]Related articles

Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice.

Luo X, Yang H, Kim IS, Saint-Hilaire F, Thomas DA, De BP, Ozkaynak E, Muthukumar T, Hancock WW, Crystal RG, Suthanthiran M.

Transplantation. 2005 May 15;79(9):1091-6.PMID: 15880049 [PubMed - indexed for MEDLINE]Related articles

Islet regeneration during the reversal of autoimmune diabetes in NOD mice.

Kodama S, Kühtreiber W, Fujimura S, Dale EA, Faustman DL.

Science. 2003 Nov 14;302(5648):1223-7.PMID: 14615542 [PubMed - indexed for MEDLINE]Related articlesFree article

Histopathological changes in insulin, glucagon and somatostatin cells in the islets of NOD mice during cyclophosphamide-accelerated diabetes: a combined immunohistochemical and histochemical study.

Reddy S, Pathipati P, Bai Y, Robinson E, Ross JM.

J Mol Histol. 2005 May;36(4):289-300.PMID: 16200462 [PubMed - indexed for MEDLINE]Related articles

alpha-Cell neogenesis in an animal model of IDDM.

O'Reilly LA, Gu D, Sarvetnick N, Edlund H, Phillips JM, Fulford T, Cooke A.

Diabetes. 1997 Apr;46(4):599-606.PMID: 9075799 [PubMed - indexed for MEDLINE]Related articles

Can pancreatic duct-derived progenitors be a source of islet regeneration?

Xia B, Zhan XR, Yi R, Yang B.

Biochem Biophys Res Commun. 2009 Jun 12;383(4):383-5. Epub 2009 Mar 24. Review.PMID: 19324022 [PubMed - indexed for MEDLINE]Related articles

Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes.

Sherry NA, Kushner JA, Glandt M, Kitamura T, Brillantes AM, Herold KC.

Diabetes. 2006 Dec;55(12):3238-45.PMID: 17130466 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunohistochemical demonstration of leptin in pancreatic islets of non-obese diabetic and CD-1 mice: co-localization in glucagon cells and its attenuation at the onset of diabetes.

Reddy S, Lau EM, Ross JM.

J Mol Histol. 2004 Jun;35(5):511-9.PMID: 15571328 [PubMed - indexed for MEDLINE]Related articles

Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice.

Zhang C, Todorov I, Lin CL, Atkinson M, Kandeel F, Forman S, Zeng D.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2337-42. Epub 2007 Jan 31.PMID: 17267595 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity.

Martin-Pagola A, Sisino G, Allende G, Dominguez-Bendala J, Gianani R, Reijonen H, Nepom GT, Ricordi C, Ruiz P, Sageshima J, Ciancio G, Burke GW, Pugliese A.

Diabetologia. 2008 Oct;51(10):1803-13. Epub 2008 Aug 12.PMID: 18696047 [PubMed - indexed for MEDLINE]Related articles

Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?

Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC.

Diabetologia. 2005 Nov;48(11):2221-8. Epub 2005 Oct 5.PMID: 16205882 [PubMed - indexed for MEDLINE]Related articles

Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice.

Chatenoud L, Thervet E, Primo J, Bach JF.

Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):123-7.PMID: 8278351 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of pancreatic endocrine and exocrine function in patients with autoimmune pancreatitis.

Ito T, Kawabe K, Arita Y, Hisano T, Igarashi H, Funakoshi A, Sumii T, Yamanaka T, Takayanagi R.

Pancreas. 2007 Mar;34(2):254-9.PMID: 17312466 [PubMed - indexed for MEDLINE]Related articles

Combination of anti-CD4 with anti-LFA-1 and anti-CD154 monoclonal antibodies promotes long-term survival and function of neonatal porcine islet xenografts in spontaneously diabetic NOD mice.

Arefanian H, Tredget EB, Rajotte RV, Korbutt GS, Gill RG, Rayat GR.

Cell Transplant. 2007;16(8):787-98.PMID: 18087999 [PubMed - indexed for MEDLINE]Related articles