PubMed

PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic beta-cells.

Miele C, Raciti GA, Cassese A, Romano C, Giacco F, Oriente F, Paturzo F, Andreozzi F, Zabatta A, Troncone G, Bosch F, Pujol A, Chneiweiss H, Formisano P, Beguinot F.

Diabetes. 2007 Mar;56(3):622-33.PMID: 17327429 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action.

Vigliotta G, Miele C, Santopietro S, Portella G, Perfetti A, Maitan MA, Cassese A, Oriente F, Trencia A, Fiory F, Romano C, Tiveron C, Tatangelo L, Troncone G, Formisano P, Beguinot F.

Mol Cell Biol. 2004 Jun;24(11):5005-15.PMID: 15143191 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells.

Condorelli G, Vigliotta G, Trencia A, Maitan MA, Caruso M, Miele C, Oriente F, Santopietro S, Formisano P, Beguinot F.

Diabetes. 2001 Jun;50(6):1244-52.PMID: 11375323 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells.

Moritz W, Leech CA, Ferrer J, Habener JF.

Endocrinology. 2001 Jan;142(1):129-38.PMID: 11145575 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.

Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E217-29. Epub 2007 Sep 25.PMID: 17895289 [PubMed - indexed for MEDLINE]Related articlesFree article

PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells.

Hashimoto N, Kido Y, Uchida T, Matsuda T, Suzuki K, Inoue H, Matsumoto M, Ogawa W, Maeda S, Fujihara H, Ueta Y, Uchiyama Y, Akimoto K, Ohno S, Noda T, Kasuga M.

J Clin Invest. 2005 Jan;115(1):138-45.PMID: 15630453 [PubMed - indexed for MEDLINE]Related articlesFree article

Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice.

Seino S, Iwanaga T, Nagashima K, Miki T.

Diabetes. 2000 Mar;49(3):311-8. Review.PMID: 10868950 [PubMed - indexed for MEDLINE]Related articlesFree article

MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines.

Baroukh N, Ravier MA, Loder MK, Hill EV, Bounacer A, Scharfmann R, Rutter GA, Van Obberghen E.

J Biol Chem. 2007 Jul 6;282(27):19575-88. Epub 2007 Apr 26.PMID: 17462994 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells.

Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M.

J Biol Chem. 2008 Aug 1;283(31):21769-78. Epub 2008 Jun 9.PMID: 18541525 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.

Girard CA, Wunderlich FT, Shimomura K, Collins S, Kaizik S, Proks P, Abdulkader F, Clark A, Ball V, Zubcevic L, Bentley L, Clark R, Church C, Hugill A, Galvanovskis J, Cox R, Rorsman P, Brüning JC, Ashcroft FM.

J Clin Invest. 2009 Jan;119(1):80-90. doi: 10.1172/JCI35772. Epub 2008 Dec 8.PMID: 19065048 [PubMed - indexed for MEDLINE]Related articlesFree article

Foxa2 regulates multiple pathways of insulin secretion.

Lantz KA, Vatamaniuk MZ, Brestelli JE, Friedman JR, Matschinsky FM, Kaestner KH.

J Clin Invest. 2004 Aug;114(4):512-20.PMID: 15314688 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.

Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I.

J Biol Chem. 2006 Feb 24;281(8):5246-57. Epub 2005 Dec 23.PMID: 16377800 [PubMed - indexed for MEDLINE]Related articlesFree article

Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.

Perfetti A, Oriente F, Iovino S, Alberobello AT, Barbagallo AP, Esposito I, Fiory F, Teperino R, Ungaro P, Miele C, Formisano P, Beguinot F.

J Biol Chem. 2007 Mar 23;282(12):8648-57. Epub 2007 Jan 16.PMID: 17227770 [PubMed - indexed for MEDLINE]Related articlesFree article

Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release.

Wang H, Gauthier BR, Hagenfeldt-Johansson KA, Iezzi M, Wollheim CB.

J Biol Chem. 2002 May 17;277(20):17564-70. Epub 2002 Mar 1.PMID: 11875061 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose.

Ritzel RA, Hansen JB, Veldhuis JD, Butler PC.

J Clin Endocrinol Metab. 2004 Feb;89(2):795-805.PMID: 14764798 [PubMed - indexed for MEDLINE]Related articlesFree article

SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress.

Smidt K, Jessen N, Petersen AB, Larsen A, Magnusson N, Jeppesen JB, Stoltenberg M, Culvenor JG, Tsatsanis A, Brock B, Schmitz O, Wogensen L, Bush AI, Rungby J.

PLoS One. 2009 May 25;4(5):e5684.PMID: 19492079 [PubMed - indexed for MEDLINE]Related articlesFree article

PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus.

Condorelli G, Vigliotta G, Iavarone C, Caruso M, Tocchetti CG, Andreozzi F, Cafieri A, Tecce MF, Formisano P, Beguinot L, Beguinot F.

EMBO J. 1998 Jul 15;17(14):3858-66.PMID: 9670003 [PubMed - indexed for MEDLINE]Related articlesFree article

Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion.

Matsumura K, Chang BH, Fujimiya M, Chen W, Kulkarni RN, Eguchi Y, Kimura H, Kojima H, Chan L.

Mol Cell Biol. 2007 Sep;27(17):6026-37. Epub 2007 Jun 18. Erratum in: Mol Cell Biol. 2007 Oct;27(20):7354. PMID: 17576812 [PubMed - indexed for MEDLINE]Related articlesFree article

cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets.

Nakazaki M, Crane A, Hu M, Seghers V, Ullrich S, Aguilar-Bryan L, Bryan J.

Diabetes. 2002 Dec;51(12):3440-9.PMID: 12453898 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase C-zeta activation markedly enhances beta-cell proliferation: an essential role in growth factor mediated beta-cell mitogenesis.

Vasavada RC, Wang L, Fujinaka Y, Takane KK, Rosa TC, Mellado-Gil JM, Friedman PA, Garcia-Ocaña A.

Diabetes. 2007 Nov;56(11):2732-43. Epub 2007 Aug 8.PMID: 17686945 [PubMed - indexed for MEDLINE]Related articlesFree article