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    Results: 1 to 20 of 167

    1.

    Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice.

    Herbach N, Rathkolb B, Kemter E, Pichl L, Klaften M, de Angelis MH, Halban PA, Wolf E, Aigner B, Wanke R.

    Diabetes. 2007 May;56(5):1268-76. Epub 2007 Feb 15.PMID: 17303807 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    The Ins2Akita mouse as a model of early retinal complications in diabetes.

    Barber AJ, Antonetti DA, Kern TS, Reiter CE, Soans RS, Krady JK, Levison SW, Gardner TW, Bronson SK.

    Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2210-8.PMID: 15914643 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.

    Duvillié B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ.

    Endocrinology. 2002 Apr;143(4):1530-7.PMID: 11897712 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    A new model of insulin-deficient diabetes: male NOD mice with a single copy of Ins1 and no Ins2.

    Babaya N, Nakayama M, Moriyama H, Gianani R, Still T, Miao D, Yu L, Hutton JC, Eisenbarth GS.

    Diabetologia. 2006 Jun;49(6):1222-8. Epub 2006 Apr 13.PMID: 16612590 [PubMed - indexed for MEDLINE]Related articles

    5.

    Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis.

    Riggs AC, Bernal-Mizrachi E, Ohsugi M, Wasson J, Fatrai S, Welling C, Murray J, Schmidt RE, Herrera PL, Permutt MA.

    Diabetologia. 2005 Nov;48(11):2313-21. Epub 2005 Oct 8.PMID: 16215705 [PubMed - indexed for MEDLINE]Related articles

    6.

    Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes.

    Asghar Z, Yau D, Chan F, Leroith D, Chan CB, Wheeler MB.

    Diabetologia. 2006 Jan;49(1):90-9. Epub 2005 Dec 15. Erratum in: Diabetologia. 2006 Mar;49(3):614. PMID: 16362284 [PubMed - indexed for MEDLINE]Related articles

    7.

    STAT5 activity in pancreatic beta-cells influences the severity of diabetes in animal models of type 1 and 2 diabetes.

    Jackerott M, Møldrup A, Thams P, Galsgaard ED, Knudsen J, Lee YC, Nielsen JH.

    Diabetes. 2006 Oct;55(10):2705-12.PMID: 17003334 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Compensatory responses in mice carrying a null mutation for Ins1 or Ins2.

    Leroux L, Desbois P, Lamotte L, Duvillié B, Cordonnier N, Jackerott M, Jami J, Bucchini D, Joshi RL.

    Diabetes. 2001 Feb;50 Suppl 1:S150-3.PMID: 11272179 [PubMed - indexed for MEDLINE]Related articles

    9.

    Estrogenic restoration of functional pancreatic islet cytoarchitecture in diabetes (db/db) mutant C57BL/KsJ mice: relationship to estradiol localization, systemic glycemia, and persistent hyperinsulinemia.

    Garris DR, Garris BL.

    Cell Tissue Res. 2005 Feb;319(2):231-42. Epub 2004 Nov 20.PMID: 15654653 [PubMed - indexed for MEDLINE]Related articles

    10.

    Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development.

    Herbach N, Goeke B, Schneider M, Hermanns W, Wolf E, Wanke R.

    Regul Pept. 2005 Feb 15;125(1-3):103-17.PMID: 15582721 [PubMed - indexed for MEDLINE]Related articles

    11.

    Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling.

    Hong EG, Jung DY, Ko HJ, Zhang Z, Ma Z, Jun JY, Kim JH, Sumner AD, Vary TC, Gardner TW, Bronson SK, Kim JK.

    Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1687-96. Epub 2007 Oct 2.PMID: 17911348 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B.

    Walz HA, Härndahl L, Wierup N, Zmuda-Trzebiatowska E, Svennelid F, Manganiello VC, Ploug T, Sundler F, Degerman E, Ahrén B, Holst LS.

    J Endocrinol. 2006 Jun;189(3):629-41.PMID: 16731793 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period.

    Kayo T, Koizumi A.

    J Clin Invest. 1998 May 15;101(10):2112-8.PMID: 9593767 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse.

    Izumi T, Yokota-Hashimoto H, Zhao S, Wang J, Halban PA, Takeuchi T.

    Diabetes. 2003 Feb;52(2):409-16.PMID: 12540615 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse.

    Wang J, Takeuchi T, Tanaka S, Kubo SK, Kayo T, Lu D, Takata K, Koizumi A, Izumi T.

    J Clin Invest. 1999 Jan;103(1):27-37.PMID: 9884331 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Characterization of beta-cell function of pancreatic islets isolated from bank voles developing glucose intolerance/diabetes: an animal model showing features of both type 1 and type 2 diabetes mellitus, and a possible role of the Ljungan virus.

    Blixt M, Niklasson B, Sandler S.

    Gen Comp Endocrinol. 2007 Oct-Dec;154(1-3):41-7. Epub 2007 Jul 4.PMID: 17686482 [PubMed - indexed for MEDLINE]Related articles

    17.

    c-Kit in early onset of diabetes: a morphological and functional analysis of pancreatic beta-cells in c-KitW-v mutant mice.

    Krishnamurthy M, Ayazi F, Li J, Lyttle AW, Woods M, Wu Y, Yee SP, Wang R.

    Endocrinology. 2007 Nov;148(11):5520-30. Epub 2007 Aug 2.PMID: 17673521 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Phenotypic alterations in insulin-deficient mutant mice.

    Duvillié B, Cordonnier N, Deltour L, Dandoy-Dron F, Itier JM, Monthioux E, Jami J, Joshi RL, Bucchini D.

    Proc Natl Acad Sci U S A. 1997 May 13;94(10):5137-40.PMID: 9144203 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program.

    Inoue M, Sakuraba Y, Motegi H, Kubota N, Toki H, Matsui J, Toyoda Y, Miwa I, Terauchi Y, Kadowaki T, Shigeyama Y, Kasuga M, Adachi T, Fujimoto N, Matsumoto R, Tsuchihashi K, Kagami T, Inoue A, Kaneda H, Ishijima J, Masuya H, Suzuki T, Wakana S, Gondo Y, Minowa O, Shiroishi T, Noda T.

    Hum Mol Genet. 2004 Jun 1;13(11):1147-57. Epub 2004 Apr 21.PMID: 15102714 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

    Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M.

    Diabetologia. 2007 Dec;50(12):2486-94. Epub 2007 Sep 30.PMID: 17906960 [PubMed - indexed for MEDLINE]Related articles

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