PubMed

Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism.

Vetrivel KS, Gong P, Bowen JW, Cheng H, Chen Y, Carter M, Nguyen PD, Placanica L, Wieland FT, Li YM, Kounnas MZ, Thinakaran G.

Mol Neurodegener. 2007 Feb 8;2:4.PMID: 17288597 [PubMed]Related articlesFree article

Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1.

Liu Y, Zhang YW, Wang X, Zhang H, You X, Liao FF, Xu H.

J Biol Chem. 2009 May 1;284(18):12145-52. Epub 2009 Mar 10.PMID: 19276086 [PubMed - indexed for MEDLINE]Related articles

TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin.

Dolcini V, Dunys J, Sevalle J, Chen F, Guillot-Sestier MV, St George-Hyslop P, Fraser PE, Checler F.

Biochem Biophys Res Commun. 2008 Jun 20;371(1):69-74. Epub 2008 Apr 9.PMID: 18405662 [PubMed - indexed for MEDLINE]Related articles

Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.

Winkler E, Hobson S, Fukumori A, Dümpelfeld B, Luebbers T, Baumann K, Haass C, Hopf C, Steiner H.

Biochemistry. 2009 Feb 17;48(6):1183-97.PMID: 19159235 [PubMed - indexed for MEDLINE]Related articles

Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.

Kumar VB, Franko M, Banks WA, Kasinadhuni P, Farr SA, Vyas K, Choudhuri V, Morley JE.

J Exp Biol. 2009 Feb;212(Pt 4):494-8.PMID: 19181896 [PubMed - indexed for MEDLINE]Related articlesFree article

TMP21 transmembrane domain regulates gamma-secretase cleavage.

Pardossi-Piquard R, Böhm C, Chen F, Kanemoto S, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE.

J Biol Chem. 2009 Oct 16;284(42):28634-41. Epub 2009 Aug 25.PMID: 19710022 [PubMed - indexed for MEDLINE]Related articlesFree article

GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.

Wahle T, Thal DR, Sastre M, Rentmeister A, Bogdanovic N, Famulok M, Heneka MT, Walter J.

J Neurosci. 2006 Dec 6;26(49):12838-46.PMID: 17151287 [PubMed - indexed for MEDLINE]Related articlesFree article

Biogenesis of gamma-secretase early in the secretory pathway.

Kim J, Kleizen B, Choy R, Thinakaran G, Sisodia SS, Schekman RW.

J Cell Biol. 2007 Dec 3;179(5):951-63.PMID: 18056412 [PubMed - indexed for MEDLINE]Related articlesFree article

Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells.

Wiley JC, Meabon JS, Frankowski H, Smith EA, Schecterson LC, Bothwell M, Ladiges WC.

PLoS One. 2010 Feb 9;5(2):e9135.PMID: 20161760 [PubMed - in process]Related articlesFree article

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.

J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. Epub 2009 Aug 11.PMID: 19671883 [PubMed - indexed for MEDLINE]Related articles

Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.

Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE.

J Biol Chem. 2006 Oct 27;281(43):32240-53. Epub 2006 Aug 31.PMID: 16945923 [PubMed - indexed for MEDLINE]Related articlesFree article

APP-BP1 inhibits Abeta42 levels by interacting with Presenilin-1.

Chen Y, Bodles AM, McPhie DL, Neve RL, Mrak RE, Griffin WS.

Mol Neurodegener. 2007 Feb 7;2:3.PMID: 17286867 [PubMed]Related articlesFree article

A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.

Schöbel S, Neumann S, Hertweck M, Dislich B, Kuhn PH, Kremmer E, Seed B, Baumeister R, Haass C, Lichtenthaler SF.

J Biol Chem. 2008 May 23;283(21):14257-68. Epub 2008 Mar 19.PMID: 18353773 [PubMed - indexed for MEDLINE]Related articlesFree article

Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.

Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A.

J Biol Chem. 2008 Jun 13;283(24):16488-96. Epub 2008 Apr 21.PMID: 18430735 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein.

Yang T, Arslanova D, Gu Y, Augelli-Szafran C, Xia W.

Mol Brain. 2008 Nov 4;1(1):15.PMID: 18983676 [PubMed - in process]Related articlesFree article

A novel immunotherapy for Alzheimer's disease: antibodies against the beta-secretase cleavage site of APP.

Arbel M, Solomon B.

Curr Alzheimer Res. 2007 Sep;4(4):437-45. Review.PMID: 17908048 [PubMed - indexed for MEDLINE]Related articles

ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity.

Fuentealba RA, Barría MI, Lee J, Cam J, Araya C, Escudero CA, Inestrosa NC, Bronfman FC, Bu G, Marzolo MP.

Mol Neurodegener. 2007 Jul 9;2:14.PMID: 17620134 [PubMed]Related articlesFree article

Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins.

Dorval V, Mazzella MJ, Mathews PM, Hay RT, Fraser PE.

Biochem J. 2007 Jun 1;404(2):309-16.PMID: 17346237 [PubMed - indexed for MEDLINE]Related articlesFree article

Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro.

Mei Z, Zhang F, Tao L, Zheng W, Cao Y, Wang Z, Tang S, Le K, Chen S, Pi R, Liu P.

Neurosci Lett. 2009 Mar 13;452(2):90-5. Epub 2009 Jan 13.PMID: 19154776 [PubMed - indexed for MEDLINE]Related articles

High content analysis of gamma-secretase activity reveals variable dominance of presenilin mutations linked to familial Alzheimer's disease.

Florean C, Zampese E, Zanese M, Brunello L, Ichas F, De Giorgi F, Pizzo P.

Biochim Biophys Acta. 2008 Aug;1783(8):1551-60. Epub 2008 Apr 3.PMID: 18424271 [PubMed - indexed for MEDLINE]Related articles