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    Results: 1 to 20 of 175

    1.

    Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity.

    Aerts JM, Ottenhoff R, Powlson AS, Grefhorst A, van Eijk M, Dubbelhuis PF, Aten J, Kuipers F, Serlie MJ, Wennekes T, Sethi JK, O'Rahilly S, Overkleeft HS.

    Diabetes. 2007 May;56(5):1341-9. Epub 2007 Feb 7.PMID: 17287460 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation.

    van Eijk M, Aten J, Bijl N, Ottenhoff R, van Roomen CP, Dubbelhuis PF, Seeman I, Ghauharali-van der Vlugt K, Overkleeft HS, Arbeeny C, Groen AK, Aerts JM.

    PLoS One. 2009;4(3):e4723. Epub 2009 Mar 23.PMID: 19305508 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    The glucosylceramide synthase inhibitor N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin induces sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells.

    Bijl N, Scheij S, Houten S, Boot RG, Groen AK, Aerts JM.

    J Pharmacol Exp Ther. 2008 Sep;326(3):849-55. Epub 2008 Jun 12.PMID: 18550691 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice.

    Bijl N, van Roomen CP, Triantis V, Sokolovic M, Ottenhoff R, Scheij S, van Eijk M, Boot RG, Aerts JM, Groen AK.

    Hepatology. 2009 Feb;49(2):637-45.PMID: 19072830 [PubMed - indexed for MEDLINE]Related articles

    5.

    Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice.

    Bijl N, Sokolović M, Vrins C, Langeveld M, Moerland PD, Ottenhoff R, van Roomen CP, Claessen N, Boot RG, Aten J, Groen AK, Aerts JM, van Eijk M.

    Hepatology. 2009 Nov;50(5):1431-41.PMID: 19731235 [PubMed - in process]Related articles

    6.

    Inhibition of glycolipid biosynthesis by N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin protects against the inflammatory response in hapten-induced colitis.

    Shen C, Bullens D, Kasran A, Maerten P, Boon L, Aerts JM, Van Assche G, Geboes K, Rutgeerts P, Ceuppens JL.

    Int Immunopharmacol. 2004 Jul;4(7):939-51.PMID: 15182733 [PubMed - indexed for MEDLINE]Related articles

    7.

    Extensive glycosphingolipid depletion in the liver and lymphoid organs of mice treated with N-butyldeoxynojirimycin.

    Platt FM, Reinkensmeier G, Dwek RA, Butters TD.

    J Biol Chem. 1997 Aug 1;272(31):19365-72.PMID: 9235935 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Ganglioside GM3 participates in the pathological conditions of insulin resistance.

    Tagami S, Inokuchi Ji J, Kabayama K, Yoshimura H, Kitamura F, Uemura S, Ogawa C, Ishii A, Saito M, Ohtsuka Y, Sakaue S, Igarashi Y.

    J Biol Chem. 2002 Feb 1;277(5):3085-92. Epub 2001 Nov 13.PMID: 11707432 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.

    Wennekes T, van den Berg RJ, Donker W, van der Marel GA, Strijland A, Aerts JM, Overkleeft HS.

    J Org Chem. 2007 Feb 16;72(4):1088-97. Epub 2007 Jan 23.PMID: 17243712 [PubMed - indexed for MEDLINE]Related articles

    10.

    Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy.

    Fox TE, Han X, Kelly S, Merrill AH 2nd, Martin RE, Anderson RE, Gardner TW, Kester M.

    Diabetes. 2006 Dec;55(12):3573-80.PMID: 17130506 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes.

    Zhao H, Przybylska M, Wu IH, Zhang J, Siegel C, Komarnitsky S, Yew NS, Cheng SH.

    Diabetes. 2007 May;56(5):1210-8.PMID: 17470562 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Insulin resistance as a membrane microdomain disorder.

    Inokuchi J.

    Biol Pharm Bull. 2006 Aug;29(8):1532-7. Review.PMID: 16880599 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells.

    Bieberich E, Freischütz B, Suzuki M, Yu RK.

    J Neurochem. 1999 Mar;72(3):1040-9.PMID: 10037475 [PubMed - indexed for MEDLINE]Related articles

    14.

    A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice.

    Fujimoto M, Shimizu N, Kunii K, Martyn JA, Ueki K, Kaneki M.

    Diabetes. 2005 May;54(5):1340-8.PMID: 15855318 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Beta-glycosphingolipids improve glucose intolerance and hepatic steatosis of the Cohen diabetic rat.

    Zigmond E, Zangen SW, Pappo O, Sklair-Levy M, Lalazar G, Zolotaryova L, Raz I, Ilan Y.

    Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E72-8. Epub 2008 Oct 21.PMID: 18940939 [PubMed - indexed for MEDLINE]Related articles

    16.

    Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced obese mice.

    Tsuchiya K, Sakai H, Suzuki N, Iwashima F, Yoshimoto T, Shichiri M, Hirata Y.

    Endocrinology. 2007 Oct;148(10):4548-56. Epub 2007 Jun 21.PMID: 17584959 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice.

    Hirasaka K, Kohno S, Goto J, Furochi H, Mawatari K, Harada N, Hosaka T, Nakaya Y, Ishidoh K, Obata T, Ebina Y, Gu H, Takeda S, Kishi K, Nikawa T.

    Diabetes. 2007 Oct;56(10):2511-22. Epub 2007 Jun 29.PMID: 17601987 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice.

    Zhao H, Przybylska M, Wu IH, Zhang J, Maniatis P, Pacheco J, Piepenhagen P, Copeland D, Arbeeny C, Shayman JA, Aerts JM, Jiang C, Cheng SH, Yew NS.

    Hepatology. 2009 Jul;50(1):85-93.PMID: 19444873 [PubMed - indexed for MEDLINE]Related articles

    19.

    Induction of glucosylceramide synthase by synthase inhibitors and ceramide.

    Abe A, Radin NS, Shayman JA.

    Biochim Biophys Acta. 1996 Feb 16;1299(3):333-41.PMID: 8597588 [PubMed - indexed for MEDLINE]Related articles

    20.

    Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells.

    Norris-Cervetto E, Callaghan R, Platt FM, Dwek RA, Butters TD.

    J Biol Chem. 2004 Sep 24;279(39):40412-8. Epub 2004 Jul 19.PMID: 15263008 [PubMed - indexed for MEDLINE]Related articlesFree article

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