PubMed

Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1.

Okamoto Y, Ogawa W, Nishizawa A, Inoue H, Teshigawara K, Kinoshita S, Matsuki Y, Watanabe E, Hiramatsu R, Sakaue H, Noda T, Kasuga M.

Diabetes. 2007 Apr;56(4):1000-9. Epub 2007 Jan 31.PMID: 17267763 [PubMed - indexed for MEDLINE]Related articlesFree article

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure.

Mora A, Lipina C, Tronche F, Sutherland C, Alessi DR.

Biochem J. 2005 Feb 1;385(Pt 3):639-48.PMID: 15554902 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved metabolic disorders of insulin receptor-deficient mice by transgenic overexpression of glucokinase in the liver.

Jackerott M, Baudry A, Bucchini D, Jami J, Joshi RL.

Diabetologia. 2002 Sep;45(9):1292-7. Epub 2002 Jul 31.PMID: 12242462 [PubMed - indexed for MEDLINE]Related articles

Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin.

Andreelli F, Foretz M, Knauf C, Cani PD, Perrin C, Iglesias MA, Pillot B, Bado A, Tronche F, Mithieux G, Vaulont S, Burcelin R, Viollet B.

Endocrinology. 2006 May;147(5):2432-41. Epub 2006 Feb 2.PMID: 16455782 [PubMed - indexed for MEDLINE]Related articlesFree article

FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression.

Zhang W, Patil S, Chauhan B, Guo S, Powell DR, Le J, Klotsas A, Matika R, Xiao X, Franks R, Heidenreich KA, Sajan MP, Farese RV, Stolz DB, Tso P, Koo SH, Montminy M, Unterman TG.

J Biol Chem. 2006 Apr 14;281(15):10105-17. Epub 2006 Feb 21.PMID: 16492665 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of human hepatic glucokinase in transgenic mice liver results in decreased glucose levels and reduced body weight.

Hariharan N, Farrelly D, Hagan D, Hillyer D, Arbeeny C, Sabrah T, Treloar A, Brown K, Kalinowski S, Mookhtiar K.

Diabetes. 1997 Jan;46(1):11-6.PMID: 8971074 [PubMed - indexed for MEDLINE]Related articles

A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression.

Wu C, Okar DA, Stoeckman AK, Peng LJ, Herrera AH, Herrera JE, Towle HC, Lange AJ.

Endocrinology. 2004 Feb;145(2):650-8. Epub 2003 Nov 14.PMID: 14617577 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased hepatic futile cycling compensates for increased glucose disposal in the Pten heterodeficient mouse.

Xu J, Gowen L, Raphalides C, Hoyer KK, Weinger JG, Renard M, Troke JJ, Vaitheesyaran B, Lee WN, Saad MF, Sleeman MW, Teitell MA, Kurland IJ.

Diabetes. 2006 Dec;55(12):3372-80.PMID: 17130482 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance.

Ferre T, Riu E, Franckhauser S, Agudo J, Bosch F.

Diabetologia. 2003 Dec;46(12):1662-8. Epub 2003 Nov 12.PMID: 14614559 [PubMed - indexed for MEDLINE]Related articles

Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver.

Ferre T, Riu E, Bosch F, Valera A.

FASEB J. 1996 Aug;10(10):1213-8.PMID: 8751724 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele.

Rossetti L, Chen W, Hu M, Hawkins M, Barzilai N, Efrat S.

Am J Physiol. 1997 Oct;273(4 Pt 1):E743-50.PMID: 9357804 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of the liver-specific expression of SHIP2 (SH2-containing inositol 5'-phosphatase 2) on insulin signaling and glucose metabolism in mice.

Fukui K, Wada T, Kagawa S, Nagira K, Ikubo M, Ishihara H, Kobayashi M, Sasaoka T.

Diabetes. 2005 Jul;54(7):1958-67.PMID: 15983195 [PubMed - indexed for MEDLINE]Related articlesFree article

Correction of diabetic alterations by glucokinase.

Ferre T, Pujol A, Riu E, Bosch F, Valera A.

Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7225-30.PMID: 8692973 [PubMed - indexed for MEDLINE]Related articlesFree article

Phenotypic correction of diabetic mice by adenovirus-mediated glucokinase expression.

Desai UJ, Slosberg ED, Boettcher BR, Caplan SL, Fanelli B, Stephan Z, Gunther VJ, Kaleko M, Connelly S.

Diabetes. 2001 Oct;50(10):2287-95.PMID: 11574410 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus-mediated expression of glucokinase in the liver as an adjuvant treatment for type 1 diabetes.

Morral N, McEvoy R, Dong H, Meseck M, Altomonte J, Thung S, Woo SL.

Hum Gene Ther. 2002 Sep 1;13(13):1561-70.PMID: 12228011 [PubMed - indexed for MEDLINE]Related articles

Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism.

Niswender KD, Shiota M, Postic C, Cherrington AD, Magnuson MA.

J Biol Chem. 1997 Sep 5;272(36):22570-5.PMID: 9278411 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice.

Yang R, Wilcox DM, Haasch DL, Jung PM, Nguyen PT, Voorbach MJ, Doktor S, Brodjian S, Bush EN, Lin E, Jacobson PB, Collins CA, Landschulz KT, Trevillyan JM, Rondinone CM, Surowy TK.

J Biol Chem. 2007 Aug 3;282(31):22765-74. Epub 2007 Jun 5.PMID: 17550900 [PubMed - indexed for MEDLINE]Related articlesFree article

Host cells reduce glucose uptake and glycogen deposition in response to hepatic insulin gene therapy.

Porter MH, Paveglio SA, Zhang JA, Olson DE, Campbell AG, Thulé PM.

J Investig Med. 2005 May;53(4):201-12.PMID: 15974246 [PubMed - indexed for MEDLINE]Related articles

Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle.

Mas A, Montané J, Anguela XM, Muñoz S, Douar AM, Riu E, Otaegui P, Bosch F.

Diabetes. 2006 Jun;55(6):1546-53.PMID: 16731816 [PubMed - indexed for MEDLINE]Related articlesFree article

Normalization of prandial blood glucose and improvement of glucose tolerance by liver-specific inhibition of SH2 domain containing inositol phosphatase 2 (SHIP2) in diabetic KKAy mice: SHIP2 inhibition causes insulin-mimetic effects on glycogen metabolism, gluconeogenesis, and glycolysis.

Grempler R, Zibrova D, Schoelch C, van Marle A, Rippmann JF, Redemann N.

Diabetes. 2007 Sep;56(9):2235-41. Epub 2007 Jun 27.PMID: 17596404 [PubMed - indexed for MEDLINE]Related articlesFree article