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    Results: 1 to 20 of 214

    1.

    Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.

    Florez JC, Jablonski KA, Kahn SE, Franks PW, Dabelea D, Hamman RF, Knowler WC, Nathan DM, Altshuler D.

    Diabetes. 2007 Feb;56(2):531-6.PMID: 17259403 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.

    Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM.

    Diabetes. 2003 Feb;52(2):568-72.PMID: 12540637 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses.

    van Dam RM, Hoebee B, Seidell JC, Schaap MM, de Bruin TW, Feskens EJ.

    Diabet Med. 2005 May;22(5):590-8.PMID: 15842514 [PubMed - indexed for MEDLINE]Related articles

    4.

    Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.

    Florez JC, Burtt N, de Bakker PI, Almgren P, Tuomi T, Holmkvist J, Gaudet D, Hudson TJ, Schaffner SF, Daly MJ, Hirschhorn JN, Groop L, Altshuler D.

    Diabetes. 2004 May;53(5):1360-8.PMID: 15111507 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study.

    Laukkanen O, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M; Finnish Diabetes Prevention Study Group.

    J Clin Endocrinol Metab. 2004 Dec;89(12):6286-90.PMID: 15579791 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes.

    Kilpeläinen TO, Lakka TA, Laaksonen DE, Laukkanen O, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M; Finnish Diabetes Prevention Study Group.

    Physiol Genomics. 2007 Oct 22;31(2):264-72. Epub 2007 Jul 17. Erratum in: Physiol Genomics. 2008 Feb 19;32(3):419. PMID: 17636114 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Association of KCNJ11 and ABCC8 genetic polymorphisms with response to repaglinide in Chinese diabetic patients.

    He YY, Zhang R, Shao XY, Hu C, Wang CR, Lu JX, Bao YQ, Jia WP, Xiang KS.

    Acta Pharmacol Sin. 2008 Aug;29(8):983-9.PMID: 18664331 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the Japanese population.

    Sakamoto Y, Inoue H, Keshavarz P, Miyawaki K, Yamaguchi Y, Moritani M, Kunika K, Nakamura N, Yoshikawa T, Yasui N, Shiota H, Tanahashi T, Itakura M.

    J Hum Genet. 2007;52(10):781-93. Epub 2007 Sep 6.PMID: 17823772 [PubMed - indexed for MEDLINE]Related articles

    9.

    Genetic variations in the pancreatic ATP-sensitive potassium channel, beta-cell dysfunction, and susceptibility to type 2 diabetes.

    Chistiakov DA, Potapov VA, Khodirev DC, Shamkhalova MS, Shestakova MV, Nosikov VV.

    Acta Diabetol. 2009 Mar;46(1):43-9. Epub 2008 Aug 29.PMID: 18758683 [PubMed - indexed for MEDLINE]Related articles

    10.

    Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: the sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor 1alpha genes.

    Elbein SC, Sun J, Scroggin E, Teng K, Hasstedt SJ.

    Diabetes Care. 2001 Mar;24(3):472-8.PMID: 11289470 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.

    Nielsen EM, Hansen L, Carstensen B, Echwald SM, Drivsholm T, Glümer C, Thorsteinsson B, Borch-Johnsen K, Hansen T, Pedersen O.

    Diabetes. 2003 Feb;52(2):573-7.PMID: 12540638 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Prevalence of permanent neonatal diabetes in Slovakia and successful replacement of insulin with sulfonylurea therapy in KCNJ11 and ABCC8 mutation carriers.

    Stanik J, Gasperikova D, Paskova M, Barak L, Javorkova J, Jancova E, Ciljakova M, Hlava P, Michalek J, Flanagan SE, Pearson E, Hattersley AT, Ellard S, Klimes I.

    J Clin Endocrinol Metab. 2007 Apr;92(4):1276-82. Epub 2007 Jan 9.PMID: 17213273 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.

    Villareal DT, Koster JC, Robertson H, Akrouh A, Miyake K, Bell GI, Patterson BW, Nichols CG, Polonsky KS.

    Diabetes. 2009 Aug;58(8):1869-78. Epub 2009 Jun 2.PMID: 19491206 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Relationship between E23K (an established type II diabetes-susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels.

    Barber TM, Bennett AJ, Gloyn AL, Groves CJ, Sovio U, Ruokonen A, Martikainen H, Pouta A, Taponen S, Weedon MN, Hartikainen AL, Wass JA, Järvelin MR, Zeggini E, Franks S, McCarthy MI.

    Eur J Hum Genet. 2007 Jun;15(6):679-84. Epub 2007 Mar 7.PMID: 17342155 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.

    Hamming KS, Soliman D, Matemisz LC, Niazi O, Lang Y, Gloyn AL, Light PE.

    Diabetes. 2009 Oct;58(10):2419-24. Epub 2009 Jul 8.PMID: 19587354 [PubMed - indexed for MEDLINE]Related articles

    16.

    Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus.

    Shaat N, Ekelund M, Lernmark A, Ivarsson S, Almgren P, Berntorp K, Groop L.

    Diabetologia. 2005 Dec;48(12):2544-51. Epub 2005 Nov 17.PMID: 16320083 [PubMed - indexed for MEDLINE]Related articles

    17.

    The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.

    Sesti G, Laratta E, Cardellini M, Andreozzi F, Del Guerra S, Irace C, Gnasso A, Grupillo M, Lauro R, Hribal ML, Perticone F, Marchetti P.

    J Clin Endocrinol Metab. 2006 Jun;91(6):2334-9. Epub 2006 Apr 4.PMID: 16595597 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Reduced second phase insulin secretion in carriers of a sulphonylurea receptor gene variant associating with Type II diabetes mellitus.

    Hart LM, Dekker JM, van Haeften TW, Ruige JB, Stehouwer CD, Erkelens DW, Heine RJ, Maassen JA.

    Diabetologia. 2000 Apr;43(4):515-9.PMID: 10819247 [PubMed - indexed for MEDLINE]Related articles

    19.

    TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program.

    Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PI, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D; Diabetes Prevention Program Research Group.

    N Engl J Med. 2006 Jul 20;355(3):241-50.PMID: 16855264 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects.

    Yokoi N, Kanamori M, Horikawa Y, Takeda J, Sanke T, Furuta H, Nanjo K, Mori H, Kasuga M, Hara K, Kadowaki T, Tanizawa Y, Oka Y, Iwami Y, Ohgawara H, Yamada Y, Seino Y, Yano H, Cox NJ, Seino S.

    Diabetes. 2006 Aug;55(8):2379-86.PMID: 16873704 [PubMed - indexed for MEDLINE]Related articlesFree article

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