PubMed

Glucotoxicity in the INS-1 rat insulinoma cell line is mediated by the orphan nuclear receptor small heterodimer partner.

Park KG, Lee KM, Seo HY, Suh JH, Kim HS, Wang L, Won KC, Lee HW, Park JY, Lee KU, Kim JG, Kim BW, Choi HS, Lee IK.

Diabetes. 2007 Feb;56(2):431-7.PMID: 17259388 [PubMed - indexed for MEDLINE]Related articlesFree article

Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner.

Seo HY, Kim YD, Lee KM, Min AK, Kim MK, Kim HS, Won KC, Park JY, Lee KU, Choi HS, Park KG, Lee IK.

Endocrinology. 2008 Aug;149(8):3832-41. Epub 2008 May 1.PMID: 18450959 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity.

Ubeda M, Rukstalis JM, Habener JF.

J Biol Chem. 2006 Sep 29;281(39):28858-64. Epub 2006 Aug 3.PMID: 16887799 [PubMed - indexed for MEDLINE]Related articlesFree article

Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels.

Zitzer H, Wente W, Brenner MB, Sewing S, Buschard K, Gromada J, Efanov AM.

Endocrinology. 2006 Aug;147(8):3898-905. Epub 2006 Apr 27.PMID: 16644917 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor-alpha regulates the expression of pancreatic/duodenal homeobox-1 in rat insulinoma (INS-1) cells and ameliorates glucose-induced insulin secretion impaired by palmitate.

Sun Y, Zhang L, Gu HF, Han W, Ren M, Wang F, Gong B, Wang L, Guo H, Xin W, Zhao J, Gao L.

Endocrinology. 2008 Feb;149(2):662-71. Epub 2007 Nov 8.PMID: 17991720 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor beta induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene-1 in rat insulinoma cells.

Sayo Y, Hosokawa H, Imachi H, Murao K, Sato M, Wong NC, Ishida T, Takahara J.

Eur J Biochem. 2000 Feb;267(4):971-8.PMID: 10672004 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin reduces glucotoxicity-induced apoptosis of INS-1 rat insulin-secreting cells on a microfluidic chip.

Lin P, Chen L, Li D, Liu J, Yang N, Sun Y, Xu Y, Fu Y, Hou X.

Tohoku J Exp Med. 2009 Jan;217(1):59-65.PMID: 19155609 [PubMed - indexed for MEDLINE]Related articlesFree article

Sodium arsenite induces orphan nuclear receptor SHP gene expression via AMP-activated protein kinase to inhibit gluconeogenic enzyme gene expression.

Chanda D, Kim SJ, Lee IK, Shong M, Choi HS.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E368-79. Epub 2008 May 27.PMID: 18505831 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells.

Zhang X, Sun N, Wang L, Guo H, Guan Q, Cui B, Tian L, Gao L, Zhao J.

J Cell Mol Med. 2009 Apr;13(4):758-70.PMID: 19438972 [PubMed - indexed for MEDLINE]Related articles

Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element.

Pino MF, Ye DZ, Linning KD, Green CD, Wicksteed B, Poitout V, Olson LK.

Mol Endocrinol. 2005 May;19(5):1343-60. Epub 2005 Jan 13.PMID: 15650027 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP.

Kim YD, Park KG, Lee YS, Park YY, Kim DK, Nedumaran B, Jang WG, Cho WJ, Ha J, Lee IK, Lee CH, Choi HS.

Diabetes. 2008 Feb;57(2):306-14. Epub 2007 Oct 1.PMID: 17909097 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of short heterodimer partner recovers impaired glucose-stimulated insulin secretion of pancreatic beta-cells overexpressing UCP2.

Suh YH, Kim SY, Lee HY, Jang BC, Bae JH, Sohn JN, Bae JH, Suh SI, Park JW, Lee KU, Song DK.

J Endocrinol. 2004 Oct;183(1):133-44.PMID: 15525581 [PubMed - indexed for MEDLINE]Related articlesFree article

Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.

Hagman DK, Hays LB, Parazzoli SD, Poitout V.

J Biol Chem. 2005 Sep 16;280(37):32413-8. Epub 2005 Jun 8.PMID: 15944145 [PubMed - indexed for MEDLINE]Related articlesFree article

MAFA controls genes implicated in insulin biosynthesis and secretion.

Wang H, Brun T, Kataoka K, Sharma AJ, Wollheim CB.

Diabetologia. 2007 Feb;50(2):348-58. Epub 2006 Dec 6.PMID: 17149590 [PubMed - indexed for MEDLINE]Related articlesFree article

Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.

Kim JY, Chu K, Kim HJ, Seong HA, Park KC, Sanyal S, Takeda J, Ha H, Shong M, Tsai MJ, Choi HS.

Mol Endocrinol. 2004 Apr;18(4):776-90. Epub 2004 Jan 29.PMID: 14752053 [PubMed - indexed for MEDLINE]Related articlesFree article

Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis.

Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD.

Mol Endocrinol. 2006 Nov;20(11):2671-81. Epub 2006 Jun 27. Retraction in: Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD. Mol Endocrinol. 2008 Sep;22(9):2203. PMID: 16803864 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.

Hagman DK, Latour MG, Chakrabarti SK, Fontes G, Amyot J, Tremblay C, Semache M, Lausier JA, Roskens V, Mirmira RG, Jetton TL, Poitout V.

Diabetes. 2008 Feb;57(2):424-31. Epub 2007 Nov 8.PMID: 17991758 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.

Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E217-29. Epub 2007 Sep 25.PMID: 17895289 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential regulation of human and mouse orphan nuclear receptor small heterodimer partner promoter by sterol regulatory element binding protein-1.

Kim HJ, Kim JY, Kim JY, Park SK, Seo JH, Kim JB, Lee IK, Kim KS, Choi HS.

J Biol Chem. 2004 Jul 2;279(27):28122-31. Epub 2004 Apr 30.PMID: 15123650 [PubMed - indexed for MEDLINE]Related articlesFree article

Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic beta-cells.

Thomas MK, Lee JH, Rastalsky N, Habener JF.

Endocrinology. 2001 Mar;142(3):1033-40.PMID: 11181516 [PubMed - indexed for MEDLINE]Related articlesFree article