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    Results: 1 to 20 of 850

    1.

    Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance.

    Nieto-Vazquez I, Fernández-Veledo S, de Alvaro C, Rondinone CM, Valverde AM, Lorenzo M.

    Diabetes. 2007 Feb;56(2):404-13.PMID: 17259385 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Insulin resistance induced by tumor necrosis factor-alpha in myocytes and brown adipocytes.

    Lorenzo M, Fernández-Veledo S, Vila-Bedmar R, Garcia-Guerra L, De Alvaro C, Nieto-Vazquez I.

    J Anim Sci. 2008 Apr;86(14 Suppl):E94-104. Epub 2007 Oct 16. Review.PMID: 17940160 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.

    Gonzalez-Rodriguez A, Clampit JE, Escribano O, Benito M, Rondinone CM, Valverde AM.

    Endocrinology. 2007 Feb;148(2):594-608. Epub 2006 Oct 26.PMID: 17068137 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle.

    Nieto-Vazquez I, Fernández-Veledo S, de Alvaro C, Lorenzo M.

    Diabetes. 2008 Dec;57(12):3211-21. Epub 2008 Sep 16.PMID: 18796617 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells palmitate rather than tumour necrosis factor inhibits insulin-dependent protein kinase B (PKB)/Akt stimulation and glucose uptake.

    Storz P, Döppler H, Wernig A, Pfizenmaier K, Müller G.

    Eur J Biochem. 1999 Nov;266(1):17-25.PMID: 10542046 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.

    Gum RJ, Gaede LL, Koterski SL, Heindel M, Clampit JE, Zinker BA, Trevillyan JM, Ulrich RG, Jirousek MR, Rondinone CM.

    Diabetes. 2003 Jan;52(1):21-8.PMID: 12502489 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation.

    Venable CL, Frevert EU, Kim YB, Fischer BM, Kamatkar S, Neel BG, Kahn BB.

    J Biol Chem. 2000 Jun 16;275(24):18318-26.PMID: 10751417 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.

    Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB.

    J Biol Chem. 2007 Aug 17;282(33):23829-40. Epub 2007 Jun 1.PMID: 17545163 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.

    Zabolotny JM, Haj FG, Kim YB, Kim HJ, Shulman GI, Kim JK, Neel BG, Kahn BB.

    J Biol Chem. 2004 Jun 4;279(23):24844-51. Epub 2004 Mar 18.PMID: 15031294 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes.

    Mur C, Valverde AM, Kahn CR, Benito M.

    Diabetes. 2002 Mar;51(3):743-54.PMID: 11872675 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Insulin resistance associated to obesity: the link TNF-alpha.

    Nieto-Vazquez I, Fernández-Veledo S, Krämer DK, Vila-Bedmar R, Garcia-Guerra L, Lorenzo M.

    Arch Physiol Biochem. 2008 Jul;114(3):183-94. Review. Erratum in: Arch Physiol Biochem. 2009 May;115(2):117. PMID: 18629684 [PubMed - indexed for MEDLINE]Related articles

    12.

    Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner.

    de Alvaro C, Teruel T, Hernandez R, Lorenzo M.

    J Biol Chem. 2004 Apr 23;279(17):17070-8. Epub 2004 Feb 4.PMID: 14764603 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Liver X receptor agonists ameliorate TNFalpha-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression.

    Fernández-Veledo S, Nieto-Vazquez I, Rondinone CM, Lorenzo M.

    Diabetologia. 2006 Dec;49(12):3038-48. Epub 2006 Oct 27.PMID: 17072583 [PubMed - indexed for MEDLINE]Related articles

    14.

    Effect of tumor necrosis factor-alpha on the phosphorylation of tyrosine kinase receptors is associated with dynamic alterations in specific protein-tyrosine phosphatases.

    Ahmad F, Goldstein BJ.

    J Cell Biochem. 1997 Jan;64(1):117-27.PMID: 9015760 [PubMed - indexed for MEDLINE]Related articles

    15.

    Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance.

    Kim JA, Yeh DC, Ver M, Li Y, Carranza A, Conrads TP, Veenstra TD, Harrington MA, Quon MJ.

    J Biol Chem. 2005 Jun 17;280(24):23173-83. Epub 2005 Apr 22.PMID: 15849359 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Rosiglitazone ameliorates abnormal expression and activity of protein tyrosine phosphatase 1B in the skeletal muscle of fat-fed, streptozotocin-treated diabetic rats.

    Wu Y, Ouyang JP, Wu K, Wang SS, Wen CY, Xia ZY.

    Br J Pharmacol. 2005 Sep;146(2):234-43.PMID: 15997237 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Protein tyrosine phosphatase 1B: a novel target for type 2 diabetes and obesity.

    Ramachandran C, Kennedy BP.

    Curr Top Med Chem. 2003;3(7):749-57. Review.PMID: 12678842 [PubMed - indexed for MEDLINE]Related articles

    18.

    Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells.

    Egawa K, Maegawa H, Shimizu S, Morino K, Nishio Y, Bryer-Ash M, Cheung AT, Kolls JK, Kikkawa R, Kashiwagi A.

    J Biol Chem. 2001 Mar 30;276(13):10207-11. Epub 2001 Jan 2.PMID: 11136729 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Mechanism for differential effect of protein-tyrosine phosphatase 1B on Akt versus mitogen-activated protein kinase in 3T3-L1 adipocytes.

    Shimizu S, Maegawa H, Egawa K, Shi K, Bryer-Ash M, Kashiwagi A.

    Endocrinology. 2002 Dec;143(12):4563-9.PMID: 12446583 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction.

    Stephens JM, Lee J, Pilch PF.

    J Biol Chem. 1997 Jan 10;272(2):971-6.PMID: 8995390 [PubMed - indexed for MEDLINE]Related articlesFree article

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