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    Results: 1 to 20 of 233

    1.

    Identification of the amyloid-degrading enzyme neprilysin in mouse islets and potential role in islet amyloidogenesis.

    Zraika S, Hull RL, Udayasankar J, Clark A, Utzschneider KM, Tong J, Gerchman F, Kahn SE.

    Diabetes. 2007 Feb;56(2):304-10. Erratum in: Diabetes. 2007 Jun;56(6):1746. PMID: 17259373 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

    Andrikopoulos S, Verchere CB, Terauchi Y, Kadowaki T, Kahn SE.

    Diabetes. 2000 Dec;49(12):2056-62.PMID: 11118007 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid.

    Hull RL, Andrikopoulos S, Verchere CB, Vidal J, Wang F, Cnop M, Prigeon RL, Kahn SE.

    Diabetes. 2003 Feb;52(2):372-9.PMID: 12540610 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.

    D'Alessio DA, Verchere CB, Kahn SE, Hoagland V, Baskin DG, Palmiter RD, Ensinck JW.

    Diabetes. 1994 Dec;43(12):1457-61.PMID: 7958499 [PubMed - indexed for MEDLINE]Related articles

    5.

    Human islet amyloid polypeptide accumulates at similar sites in islets of transgenic mice and humans.

    de Koning EJ, Höppener JW, Verbeek JS, Oosterwijk C, van Hulst KL, Baker CA, Lips CJ, Morris JF, Clark A.

    Diabetes. 1994 May;43(5):640-4.PMID: 8168639 [PubMed - indexed for MEDLINE]Related articles

    6.

    Human islet amyloid polypeptide transgenic mice: in vivo and ex vivo models for the role of hIAPP in type 2 diabetes mellitus.

    Höppener JW, Jacobs HM, Wierup N, Sotthewes G, Sprong M, de Vos P, Berger R, Sundler F, Ahrén B.

    Exp Diabetes Res. 2008;2008:697035.PMID: 18497871 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide.

    Huang CJ, Haataja L, Gurlo T, Butler AE, Wu X, Soeller WC, Butler PC.

    Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1656-62. Epub 2007 Oct 2.PMID: 17911343 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.

    de Koning EJ, Morris ER, Hofhuis FM, Posthuma G, Höppener JW, Morris JF, Capel PJ, Clark A, Verbeek JS.

    Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8467-71.PMID: 8078905 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model.

    Höppener JW, Oosterwijk C, Nieuwenhuis MG, Posthuma G, Thijssen JH, Vroom TM, Ahrén B, Lips CJ.

    Diabetologia. 1999 Apr;42(4):427-34.PMID: 10230646 [PubMed - indexed for MEDLINE]Related articles

    10.

    Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro.

    Hull RL, Zraika S, Udayasankar J, Kisilevsky R, Szarek WA, Wight TN, Kahn SE.

    Am J Physiol Cell Physiol. 2007 Nov;293(5):C1586-93. Epub 2007 Sep 5.PMID: 17804609 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Postnatally disturbed pancreatic islet cell distribution in human islet amyloid polypeptide transgenic mice.

    Wong HY, Ahrén B, Lips CJ, Höppener JW, Sundler F.

    Regul Pept. 2003 May 15;113(1-3):89-94.PMID: 12686466 [PubMed - indexed for MEDLINE]Related articles

    12.

    Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

    Verchere CB, D'Alessio DA, Palmiter RD, Weir GC, Bonner-Weir S, Baskin DG, Kahn SE.

    Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3492-6.PMID: 8622964 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Glucose- and time-dependence of islet amyloid formation in vitro.

    Zraika S, Hull RL, Udayasankar J, Utzschneider KM, Tong J, Gerchman F, Kahn SE.

    Biochem Biophys Res Commun. 2007 Mar 2;354(1):234-9. Epub 2007 Jan 2.PMID: 17222388 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Formation of islet amyloid fibrils in beta-secretory granules of transgenic mice expressing human islet amyloid polypeptide/amylin.

    Yagui K, Yamaguchi T, Kanatsuka A, Shimada F, Huang CI, Tokuyama Y, Ohsawa H, Yamamura K, Miyazaki J, Mikata A, et al.

    Eur J Endocrinol. 1995 Apr;132(4):487-96.PMID: 7711888 [PubMed - indexed for MEDLINE]Related articles

    15.

    Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide.

    Andrikopoulos S, Hull RL, Verchere CB, Wang F, Wilbur SM, Wight TN, Marzban L, Kahn SE.

    Am J Physiol Endocrinol Metab. 2004 Mar;286(3):E418-24. Epub 2003 Nov 12. Erratum in: Am J Physiol Endocrinol Metab. 2004 May;286(5):E862. PMID: 14613923 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    An in vitro model of early islet amyloid polypeptide (IAPP) fibrillogenesis using human IAPP-transgenic mouse islets.

    Henson MS, Buman BL, Jordan K, Rahrmann EP, Hardy RM, Johnson KH, O'Brien TD.

    Amyloid. 2006 Dec;13(4):250-9.PMID: 17107885 [PubMed - indexed for MEDLINE]Related articles

    17.

    Biologically active human islet amyloid polypeptide/amylin in transgenic mice.

    van Hulst KL, Born W, Muff R, Oosterwijk C, Blankenstein MA, Lips CJ, Fischer JA, Höppener JW.

    Eur J Endocrinol. 1997 Jan;136(1):107-13.PMID: 9037136 [PubMed - indexed for MEDLINE]Related articles

    18.

    The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice.

    Vidal J, Verchere CB, Andrikopoulos S, Wang F, Hull RL, Cnop M, Olin KL, LeBoeuf RC, O'Brien KD, Chait A, Kahn SE.

    Diabetologia. 2003 Jan;46(1):71-9. Epub 2003 Jan 9.PMID: 12637985 [PubMed - indexed for MEDLINE]Related articles

    19.

    Oophorectomy promotes islet amyloid formation in a transgenic mouse model of Type II diabetes.

    Kahn SE, Andrikopoulos S, Verchere CB, Wang F, Hull RL, Vidal J.

    Diabetologia. 2000 Oct;43(10):1309-12.PMID: 11079750 [PubMed - indexed for MEDLINE]Related articles

    20.

    Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology.

    Jaikaran ET, Clark A.

    Biochim Biophys Acta. 2001 Nov 29;1537(3):179-203. Review.PMID: 11731221 [PubMed - indexed for MEDLINE]Related articles

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