PubMed

Multiple pathways contribute to the pathogenesis of Huntington disease.

Li S, Li XJ.

Mol Neurodegener. 2006 Dec 16;1:19.PMID: 17173700 [PubMed]Related articlesFree article

Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.

Wang CE, Tydlacka S, Orr AL, Yang SH, Graham RK, Hayden MR, Li S, Chan AW, Li XJ.

Hum Mol Genet. 2008 Sep 1;17(17):2738-51. Epub 2008 Jun 16.PMID: 18558632 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice.

Bradford J, Shin JY, Roberts M, Wang CE, Sheng G, Li S, Li XJ.

J Biol Chem. 2010 Feb 9. [Epub ahead of print]PMID: 20145253 [PubMed - as supplied by publisher]Related articlesFree article

Huntingtin associated protein 1 and its functions.

Wu LL, Zhou XF.

Cell Adh Migr. 2009 Jan;3(1):71-6. Epub 2009 Jan 26.PMID: 19262167 [PubMed - in process]Related articlesFree article

Selective degeneration in YAC mouse models of Huntington disease.

Van Raamsdonk JM, Warby SC, Hayden MR.

Brain Res Bull. 2007 Apr 30;72(2-3):124-31. Epub 2006 Nov 16. Review.PMID: 17352936 [PubMed - indexed for MEDLINE]Related articles

N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.

Orr AL, Li S, Wang CE, Li H, Wang J, Rong J, Xu X, Mastroberardino PG, Greenamyre JT, Li XJ.

J Neurosci. 2008 Mar 12;28(11):2783-92.PMID: 18337408 [PubMed - indexed for MEDLINE]Related articlesFree article

Inducing huntingtin inclusion formation in primary neuronal cell culture and in vivo by high-capacity adenoviral vectors expressing truncated and full-length huntingtin with polyglutamine expansion.

Huang B, Schiefer J, Sass C, Kosinski CM, Kochanek S.

J Gene Med. 2008 Mar;10(3):269-79.PMID: 18067195 [PubMed - indexed for MEDLINE]Related articles

Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment.

Legleiter J, Lotz GP, Miller J, Ko J, Ng C, Williams GL, Finkbeiner S, Patterson PH, Muchowski PJ.

J Biol Chem. 2009 Aug 7;284(32):21647-58. Epub 2009 Jun 2.PMID: 19491400 [PubMed - indexed for MEDLINE]Related articles

Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice.

Orr AL, Huang S, Roberts MA, Reed JC, Li S, Li XJ.

J Biol Chem. 2008 Jun 6;283(23):16027-36. Epub 2008 Apr 8.PMID: 18400759 [PubMed - indexed for MEDLINE]Related articlesFree article

Context-dependent dysregulation of transcription by mutant huntingtin.

Cornett J, Smith L, Friedman M, Shin JY, Li XJ, Li SH.

J Biol Chem. 2006 Nov 24;281(47):36198-204. Epub 2006 Sep 29.PMID: 17012230 [PubMed - indexed for MEDLINE]Related articlesFree article

Huntingtin-deficient zebrafish exhibit defects in iron utilization and development.

Lumsden AL, Henshall TL, Dayan S, Lardelli MT, Richards RI.

Hum Mol Genet. 2007 Aug 15;16(16):1905-20. Epub 2007 Jun 13.PMID: 17567778 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons.

Tydlacka S, Wang CE, Wang X, Li S, Li XJ.

J Neurosci. 2008 Dec 3;28(49):13285-95.PMID: 19052220 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutant Huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo.

Legleiter J, Mitchell E, Lotz GP, Sapp E, Ng C, Difiglia M, Thompson LM, Muchowski PJ.

J Biol Chem. 2010 Mar 10. [Epub ahead of print]PMID: 20220138 [PubMed - as supplied by publisher]Related articlesFree article

Towards a transgenic model of Huntington's disease in a non-human primate.

Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Cheng EC, Snyder B, Larkin K, Liu J, Orkin J, Fang ZH, Smith Y, Bachevalier J, Zola SM, Li SH, Li XJ, Chan AW.

Nature. 2008 Jun 12;453(7197):921-4. Epub 2008 May 18.PMID: 18488016 [PubMed - indexed for MEDLINE]Related articlesFree article

Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.

Zhang H, Li Q, Graham RK, Slow E, Hayden MR, Bezprozvanny I.

Neurobiol Dis. 2008 Jul;31(1):80-8. Epub 2008 Apr 16.PMID: 18502655 [PubMed - indexed for MEDLINE]Related articlesFree article

Inositol 1,4,5-tripshosphate receptor, calcium signalling and Huntington's disease.

Bezprozvanny I.

Subcell Biochem. 2007;45:323-35. Review.PMID: 18193642 [PubMed - indexed for MEDLINE]Related articles

Inhibition of Rho kinases enhances the degradation of mutant huntingtin.

Bauer PO, Wong HK, Oyama F, Goswami A, Okuno M, Kino Y, Miyazaki H, Nukina N.

J Biol Chem. 2009 May 8;284(19):13153-64. Epub 2009 Mar 11.PMID: 19278999 [PubMed - indexed for MEDLINE]Related articles

Global changes to the ubiquitin system in Huntington's disease.

Bennett EJ, Shaler TA, Woodman B, Ryu KY, Zaitseva TS, Becker CH, Bates GP, Schulman H, Kopito RR.

Nature. 2007 Aug 9;448(7154):704-8.PMID: 17687326 [PubMed - indexed for MEDLINE]Related articles

Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase.

Scappini E, Koh TW, Martin NP, O'Bryan JP.

Hum Mol Genet. 2007 Aug 1;16(15):1862-71. Epub 2007 Jun 5.PMID: 17550941 [PubMed - indexed for MEDLINE]Related articlesFree article

Nuclear accumulation of polyglutamine disease proteins and neuropathology.

Havel LS, Li S, Li XJ.

Mol Brain. 2009 Jul 3;2(1):21.PMID: 19575804 [PubMed - in process]Related articlesFree article