PubMed

Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women.

Munoz J, Lok KH, Gower BA, Fernandez JR, Hunter GR, Lara-Castro C, De Luca M, Garvey WT.

Diabetes. 2006 Dec;55(12):3630-4.PMID: 17130514 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.

Damcott CM, Pollin TI, Reinhart LJ, Ott SH, Shen H, Silver KD, Mitchell BD, Shuldiner AR.

Diabetes. 2006 Sep;55(9):2654-9.PMID: 16936218 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population.

González-Sánchez JL, Martínez-Larrad MT, Zabena C, Pérez-Barba M, Serrano-Ríos M.

Diabetologia. 2008 Nov;51(11):1993-7. Epub 2008 Aug 19.PMID: 18712344 [PubMed - indexed for MEDLINE]Related articles

Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent.

Elbein SC, Chu WS, Das SK, Yao-Borengasser A, Hasstedt SJ, Wang H, Rasouli N, Kern PA.

Diabetologia. 2007 Aug;50(8):1621-30. Epub 2007 Jun 20.PMID: 17579832 [PubMed - indexed for MEDLINE]Related articles

Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion.

Wang J, Kuusisto J, Vänttinen M, Kuulasmaa T, Lindström J, Tuomilehto J, Uusitupa M, Laakso M.

Diabetologia. 2007 Jun;50(6):1192-200. Epub 2007 Apr 17.PMID: 17437080 [PubMed - indexed for MEDLINE]Related articles

The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians.

Bodhini D, Radha V, Dhar M, Narayani N, Mohan V.

Metabolism. 2007 Sep;56(9):1174-8.PMID: 17697858 [PubMed - indexed for MEDLINE]Related articles

Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans.

Palmer ND, Lehtinen AB, Langefeld CD, Campbell JK, Haffner SM, Norris JM, Bergman RN, Goodarzi MO, Rotter JI, Bowden DW.

J Clin Endocrinol Metab. 2008 Jan;93(1):304-9. Epub 2007 Oct 30.PMID: 17971425 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects.

Saadi H, Nagelkerke N, Carruthers SG, Benedict S, Abdulkhalek S, Reed R, Lukic M, Nicholls MG.

Diabetes Res Clin Pract. 2008 Jun;80(3):392-8. Epub 2008 Feb 20.PMID: 18282631 [PubMed - indexed for MEDLINE]Related articles

Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population.

Chandak GR, Janipalli CS, Bhaskar S, Kulkarni SR, Mohankrishna P, Hattersley AT, Frayling TM, Yajnik CS.

Diabetologia. 2007 Jan;50(1):63-7. Epub 2006 Nov 9.PMID: 17093941 [PubMed - indexed for MEDLINE]Related articles

Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans.

Watanabe RM, Allayee H, Xiang AH, Trigo E, Hartiala J, Lawrence JM, Buchanan TA.

Diabetes. 2007 May;56(5):1481-5. Epub 2007 Feb 22.PMID: 17317761 [PubMed - indexed for MEDLINE]Related articlesFree article

Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population.

Chang YC, Chang TJ, Jiang YD, Kuo SS, Lee KC, Chiu KC, Chuang LM.

Diabetes. 2007 Oct;56(10):2631-7. Epub 2007 Jun 19.PMID: 17579206 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjögren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L.

J Clin Invest. 2007 Aug;117(8):2155-63.PMID: 17671651 [PubMed - indexed for MEDLINE]Related articlesFree article

A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.

Horikoshi M, Hara K, Ito C, Nagai R, Froguel P, Kadowaki T.

Diabetologia. 2007 Apr;50(4):747-51. Epub 2007 Jan 24.PMID: 17245589 [PubMed - indexed for MEDLINE]Related articles

Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men.

Dahlgren A, Zethelius B, Jensevik K, Syvänen AC, Berne C; ULSAM Cohort.

Diabetologia. 2007 Sep;50(9):1852-7. Epub 2007 Jul 6.PMID: 17618413 [PubMed - indexed for MEDLINE]Related articles

TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study.

Stolerman ES, Manning AK, McAteer JB, Fox CS, Dupuis J, Meigs JB, Florez JC.

Diabetologia. 2009 Apr;52(4):614-20. Epub 2009 Jan 31.PMID: 19183934 [PubMed - indexed for MEDLINE]Related articles

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program.

Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PI, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D; Diabetes Prevention Program Research Group.

N Engl J Med. 2006 Jul 20;355(3):241-50.PMID: 16855264 [PubMed - indexed for MEDLINE]Related articlesFree article

Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.

Sale MM, Smith SG, Mychaleckyj JC, Keene KL, Langefeld CD, Leak TS, Hicks PJ, Bowden DW, Rich SS, Freedman BI.

Diabetes. 2007 Oct;56(10):2638-42. Epub 2007 Jun 29.PMID: 17601994 [PubMed - indexed for MEDLINE]Related articlesFree article

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population.

Loos RJ, Franks PW, Francis RW, Barroso I, Gribble FM, Savage DB, Ong KK, O'Rahilly S, Wareham NJ.

Diabetes. 2007 Jul;56(7):1943-7. Epub 2007 Apr 6.PMID: 17416797 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins.

Wegner L, Hussain MS, Pilgaard K, Hansen T, Pedersen O, Vaag A, Poulsen P.

J Clin Endocrinol Metab. 2008 Oct;93(10):4013-9. Epub 2008 Jul 8.PMID: 18611970 [PubMed - indexed for MEDLINE]Related articlesFree article

TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels.

Kimber CH, Doney AS, Pearson ER, McCarthy MI, Hattersley AT, Leese GP, Morris AD, Palmer CN.

Diabetologia. 2007 Jun;50(6):1186-91. Epub 2007 Apr 11.PMID: 17429603 [PubMed - indexed for MEDLINE]Related articles