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    Results: 1 to 20 of 139

    1.

    Peroxisome proliferator-activated receptor-alpha and glucocorticoids interactively regulate insulin secretion during pregnancy.

    Holness MJ, Greenwood GK, Smith ND, Sugden MC.

    Diabetes. 2006 Dec;55(12):3501-8.PMID: 17130498 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Peroxisome proliferator-activated receptor-alpha activation during pregnancy attenuates glucose-stimulated insulin hypersecretion in vivo by increasing insulin sensitivity, without impairing pregnancy-induced increases in beta-cell glucose sensing and responsiveness.

    Sugden MC, Greenwood GK, Smith ND, Holness MJ.

    Endocrinology. 2003 Jan;144(1):146-53.PMID: 12488340 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    PPARalpha activation and increased dietary lipid oppose thyroid hormone signaling and rescue impaired glucose-stimulated insulin secretion in hyperthyroidism.

    Holness MJ, Greenwood GK, Smith ND, Sugden MC.

    Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1380-9. Epub 2008 Oct 14.PMID: 18854422 [PubMed - indexed for MEDLINE]Related articles

    4.

    Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion.

    Sugden MC, Bulmer K, Augustine D, Holness MJ.

    Diabetes. 2001 Dec;50(12):2729-36.PMID: 11723055 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Interactive influences of peroxisome proliferator-activated receptor alpha activation and glucocorticoids on pancreatic beta cell compensation in insulin resistance induced by dietary saturated fat in the rat.

    Holness MJ, Smith ND, Greenwood GK, Sugden MC.

    Diabetologia. 2005 Oct;48(10):2062-8. Epub 2005 Aug 19.PMID: 16132960 [PubMed - indexed for MEDLINE]Related articles

    6.

    Acute (24 h) activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) reverses high-fat feeding-induced insulin hypersecretion in vivo and in perifused pancreatic islets.

    Holness MJ, Smith ND, Greenwood GK, Sugden MC.

    J Endocrinol. 2003 May;177(2):197-205.PMID: 12740007 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    PPARalpha activation reverses adverse effects induced by high-saturated-fat feeding on pancreatic beta-cell function in late pregnancy.

    Holness MJ, Smith ND, Greenwood GK, Sugden MC.

    Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1087-94. Epub 2006 Dec 12.PMID: 17164438 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells.

    Ravnskjaer K, Boergesen M, Rubi B, Larsen JK, Nielsen T, Fridriksson J, Maechler P, Mandrup S.

    Endocrinology. 2005 Aug;146(8):3266-76. Epub 2005 May 5.PMID: 15878969 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    The interplay of prolactin and the glucocorticoids in the regulation of beta-cell gene expression, fatty acid oxidation, and glucose-stimulated insulin secretion: implications for carbohydrate metabolism in pregnancy.

    Arumugam R, Horowitz E, Lu D, Collier JJ, Ronnebaum S, Fleenor D, Freemark M.

    Endocrinology. 2008 Nov;149(11):5401-14. Epub 2008 Jul 3.PMID: 18599550 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Peroxisome proliferator-activated receptor-alpha regulates the expression of pancreatic/duodenal homeobox-1 in rat insulinoma (INS-1) cells and ameliorates glucose-induced insulin secretion impaired by palmitate.

    Sun Y, Zhang L, Gu HF, Han W, Ren M, Wang F, Gong B, Wang L, Guo H, Xin W, Zhao J, Gao L.

    Endocrinology. 2008 Feb;149(2):662-71. Epub 2007 Nov 8.PMID: 17991720 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARalpha).

    Bihan H, Rouault C, Reach G, Poitout V, Staels B, Guerre-Millo M.

    FEBS Lett. 2005 Apr 25;579(11):2284-8.PMID: 15848159 [PubMed - indexed for MEDLINE]Related articles

    12.

    Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation.

    Gremlich S, Nolan C, Roduit R, Burcelin R, Peyot ML, Delghingaro-Augusto V, Desvergne B, Michalik L, Prentki M, Wahli W.

    Endocrinology. 2005 Jan;146(1):375-82. Epub 2004 Sep 30.PMID: 15459119 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Dexamethasone during late gestation exacerbates peripheral insulin resistance and selectively targets glucose-sensitive functions in beta cell and liver.

    Holness MJ, Sugden MC.

    Endocrinology. 2001 Sep;142(9):3742-8.PMID: 11517149 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Hyperthyroidism impairs pancreatic beta cell adaptations to late pregnancy and maternal liporegulation in the rat.

    Holness MJ, Greenwood GK, Smith ND, Sugden MC.

    Diabetologia. 2005 Nov;48(11):2305-12. Epub 2005 Oct 5.PMID: 16205881 [PubMed - indexed for MEDLINE]Related articles

    15.

    Role of nuclear receptors in the modulation of insulin secretion in lipid-induced insulin resistance.

    Sugden MC, Holness MJ.

    Biochem Soc Trans. 2008 Oct;36(Pt 5):891-900. Review.PMID: 18793157 [PubMed - indexed for MEDLINE]Related articles

    16.

    Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets.

    Lalloyer F, Vandewalle B, Percevault F, Torpier G, Kerr-Conte J, Oosterveer M, Paumelle R, Fruchart JC, Kuipers F, Pattou F, Fiévet C, Staels B.

    Diabetes. 2006 Jun;55(6):1605-13.PMID: 16731822 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Potential role of peroxisome proliferator-activated receptor-alpha in the modulation of glucose-stimulated insulin secretion.

    Sugden MC, Holness MJ.

    Diabetes. 2004 Feb;53 Suppl 1:S71-81. Review.PMID: 14749269 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Dexamethasone counteracts the effect of prolactin on islet function: implications for islet regulation in late pregnancy.

    Weinhaus AJ, Bhagroo NV, Brelje TC, Sorenson RL.

    Endocrinology. 2000 Apr;141(4):1384-93.PMID: 10746642 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Effect of PPAR-gamma activation and inhibition on glucose-stimulated insulin release in INS-1e cells.

    Santini E, Fallahi P, Ferrari SM, Masoni A, Antonelli A, Ferrannini E.

    Diabetes. 2004 Dec;53 Suppl 3:S79-83.PMID: 15561927 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion.

    Parsons JA, Brelje TC, Sorenson RL.

    Endocrinology. 1992 Mar;130(3):1459-66.PMID: 1537300 [PubMed - indexed for MEDLINE]Related articles

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