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    Results: 1 to 20 of 325

    1.

    Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function.

    Sørensen H, Winzell MS, Brand CL, Fosgerau K, Gelling RW, Nishimura E, Ahren B.

    Diabetes. 2006 Dec;55(12):3463-9.PMID: 17130493 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Pancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and mass.

    Gelling RW, Vuguin PM, Du XQ, Cui L, Rømer J, Pederson RA, Leiser M, Sørensen H, Holst JJ, Fledelius C, Johansen PB, Fleischer N, McIntosh CH, Nishimura E, Charron MJ.

    Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E695-707. Epub 2009 Jul 14.PMID: 19602585 [PubMed - indexed for MEDLINE]Related articles

    3.

    Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice.

    Gelling RW, Du XQ, Dichmann DS, Romer J, Huang H, Cui L, Obici S, Tang B, Holst JJ, Fledelius C, Johansen PB, Rossetti L, Jelicks LA, Serup P, Nishimura E, Charron MJ.

    Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1438-43. Epub 2003 Jan 24.PMID: 12552113 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Elimination of glucagon-like peptide 1R signaling does not modify weight gain and islet adaptation in mice with combined disruption of leptin and GLP-1 action.

    Scrocchi LA, Hill ME, Saleh J, Perkins B, Drucker DJ.

    Diabetes. 2000 Sep;49(9):1552-60.PMID: 10969840 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia.

    Conarello SL, Jiang G, Mu J, Li Z, Woods J, Zycband E, Ronan J, Liu F, Roy RS, Zhu L, Charron MJ, Zhang BB.

    Diabetologia. 2007 Jan;50(1):142-50. Epub 2006 Nov 28.PMID: 17131145 [PubMed - indexed for MEDLINE]Related articles

    6.

    Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors.

    Preitner F, Ibberson M, Franklin I, Binnert C, Pende M, Gjinovci A, Hansotia T, Drucker DJ, Wollheim C, Burcelin R, Thorens B.

    J Clin Invest. 2004 Feb;113(4):635-45.PMID: 14966573 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene.

    Flamez D, Van Breusegem A, Scrocchi LA, Quartier E, Pipeleers D, Drucker DJ, Schuit F.

    Diabetes. 1998 Apr;47(4):646-52.PMID: 9568699 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis.

    Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker DJ.

    J Biol Chem. 2003 Jan 3;278(1):471-8. Epub 2002 Oct 29.PMID: 12409292 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors.

    Sloop KW, Cao JX, Siesky AM, Zhang HY, Bodenmiller DM, Cox AL, Jacobs SJ, Moyers JS, Owens RA, Showalter AD, Brenner MB, Raap A, Gromada J, Berridge BR, Monteith DK, Porksen N, McKay RA, Monia BP, Bhanot S, Watts LM, Michael MD.

    J Clin Invest. 2004 Jun;113(11):1571-81.PMID: 15173883 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion.

    De León DD, Li C, Delson MI, Matschinsky FM, Stanley CA, Stoffers DA.

    J Biol Chem. 2008 Sep 19;283(38):25786-93. Epub 2008 Jul 17.PMID: 18635551 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances beta-cell function but does not inhibit gastric emptying in mice.

    Maida A, Lovshin JA, Baggio LL, Drucker DJ.

    Endocrinology. 2008 Nov;149(11):5670-8. Epub 2008 Jul 31.PMID: 18669601 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1.

    Li Y, Cao X, Li LX, Brubaker PL, Edlund H, Drucker DJ.

    Diabetes. 2005 Feb;54(2):482-91.PMID: 15677506 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage.

    Knauf C, Cani PD, Perrin C, Iglesias MA, Maury JF, Bernard E, Benhamed F, Grémeaux T, Drucker DJ, Kahn CR, Girard J, Tanti JF, Delzenne NM, Postic C, Burcelin R.

    J Clin Invest. 2005 Dec;115(12):3554-63.PMID: 16322793 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet.

    Winzell MS, Brand CL, Wierup N, Sidelmann UG, Sundler F, Nishimura E, Ahrén B.

    Diabetologia. 2007 Jul;50(7):1453-62. Epub 2007 May 4.PMID: 17479245 [PubMed - indexed for MEDLINE]Related articles

    15.

    Increased responsiveness to the hyperglycemic, hyperglucagonemic and hyperinsulinemic effects of circulating norepinephrine in ob/ob mice.

    Liang Y, Cincotta AH.

    Int J Obes Relat Metab Disord. 2001 May;25(5):698-704.PMID: 11360153 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Insulin action in the double incretin receptor knockout mouse.

    Ayala JE, Bracy DP, Hansotia T, Flock G, Seino Y, Wasserman DH, Drucker DJ.

    Diabetes. 2008 Feb;57(2):288-97. Epub 2007 Oct 31.PMID: 17977951 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor.

    Cani PD, Knauf C, Iglesias MA, Drucker DJ, Delzenne NM, Burcelin R.

    Diabetes. 2006 May;55(5):1484-90.PMID: 16644709 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy.

    De León DD, Deng S, Madani R, Ahima RS, Drucker DJ, Stoffers DA.

    Diabetes. 2003 Feb;52(2):365-71.PMID: 12540609 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide.

    Ahrén B, Winzell MS, Wierup N, Sundler F, Burkey B, Hughes TE.

    Regul Pept. 2007 Oct 4;143(1-3):97-103. Epub 2007 Apr 11.PMID: 17482289 [PubMed - indexed for MEDLINE]Related articles

    20.

    Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis.

    Pamir N, Lynn FC, Buchan AM, Ehses J, Hinke SA, Pospisilik JA, Miyawaki K, Yamada Y, Seino Y, McIntosh CH, Pederson RA.

    Am J Physiol Endocrinol Metab. 2003 May;284(5):E931-9. Epub 2003 Jan 21.PMID: 12540373 [PubMed - indexed for MEDLINE]Related articlesFree article

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