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    Results: 1 to 20 of 286

    1.

    Modulatory role of DR4- to DQ8-restricted CD4 T-cell responses and type 1 diabetes susceptibility.

    Ge X, Piganelli JD, Tse HM, Bertera S, Mathews CE, Trucco M, Wen L, Rudert WA.

    Diabetes. 2006 Dec;55(12):3455-62.PMID: 17130492 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice.

    Liu J, Purdy LE, Rabinovitch S, Jevnikar AM, Elliott JF.

    Diabetes. 1999 Mar;48(3):469-77.PMID: 10078545 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model.

    Wen L, Chen NY, Tang J, Sherwin R, Wong FS.

    J Clin Invest. 2001 Apr;107(7):871-80.PMID: 11285306 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Type 1 diabetes-predisposing MHC alleles influence the selection of glutamic acid decarboxylase (GAD) 65-specific T cells in a transgenic model.

    Abraham RS, Wen L, Marietta EV, David CS.

    J Immunol. 2001 Jan 15;166(2):1370-9.PMID: 11145722 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice.

    Wen L, Wong FS, Burkly L, Altieri M, Mamalaki C, Kioussis D, Flavell RA, Sherwin RS.

    J Clin Invest. 1998 Sep 1;102(5):947-57. Erratum in: J Clin Invest 1998 Oct 1;102(7):following 1463. PMID: 9727063 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to type I diabetes: analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice.

    Boyton RJ, Lohmann T, Londei M, Kalbacher H, Halder T, Frater AJ, Douek DC, Leslie DG, Flavell RA, Altmann DM.

    Int Immunol. 1998 Dec;10(12):1765-76.PMID: 9885897 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Determination of glutamic acid decarboxylase 65 peptides presented by the type I diabetes-associated HLA-DQ8 class II molecule identifies an immunogenic peptide motif.

    Herman AE, Tisch RM, Patel SD, Parry SL, Olson J, Noble JA, Cope AP, Cox B, Congia M, McDevitt2 HO.

    J Immunol. 1999 Dec 1;163(11):6275-82.PMID: 10570321 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes.

    Kelemen K, Gottlieb PA, Putnam AL, Davidson HW, Wegmann DR, Hutton JC.

    J Immunol. 2004 Mar 15;172(6):3955-62.PMID: 15004204 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    An HLA-DRB1-derived peptide associated with protection against rheumatoid arthritis is naturally processed by human APCs.

    Snijders A, Elferink DG, Geluk A, van Der Zanden AL, Vos K, Schreuder GM, Breedveld FC, de Vries RR, Zanelli EH.

    J Immunol. 2001 Apr 15;166(8):4987-93.PMID: 11290778 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4.

    Peakman M, Stevens EJ, Lohmann T, Narendran P, Dromey J, Alexander A, Tomlinson AJ, Trucco M, Gorga JC, Chicz RM.

    J Clin Invest. 1999 Nov;104(10):1449-57.PMID: 10562307 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65).

    Nepom GT, Lippolis JD, White FM, Masewicz S, Marto JA, Herman A, Luckey CJ, Falk B, Shabanowitz J, Hunt DF, Engelhard VH, Nepom BS.

    Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1763-8.PMID: 11172025 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    HLA Class II molecules on haplotypes associated with type 1 diabetes exhibit similar patterns of binding affinities for coxsackievirus P2C peptides.

    Ellis RJ, Varela-Calvino R, Tree TI, Peakman M.

    Immunology. 2005 Nov;116(3):337-46.PMID: 16236123 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Reduced CCR4, interleukin-13 and GATA-3 up-regulation in response to type 2 cytokines of cord blood T lymphocytes in infants at genetic risk of type 1 diabetes.

    Luopajärvi K, Skarsvik S, Ilonen J, Akerblom HK, Vaarala O.

    Immunology. 2007 Jun;121(2):189-96. Epub 2007 Jan 18.PMID: 17244154 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Soluble, dimeric HLA DR4-peptide chimeras: an approach for detection and immunoregulation of human type-1 diabetes.

    Preda I, McEvoy RC, Lin M, Bona CA, Rapaport R, Brumeanu TD, Casares S.

    Eur J Immunol. 2005 Sep;35(9):2762-75.PMID: 16106371 [PubMed - indexed for MEDLINE]Related articles

    15.

    Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice.

    Abraham RS, Kudva YC, Wilson SB, Strominger JL, David CS.

    Diabetes. 2000 Apr;49(4):548-54.PMID: 10871191 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Prediction of HLA-DQ8beta cell peptidome using a computational program and its relationship to autoreactive T cells.

    Chang KY, Unanue ER.

    Int Immunol. 2009 Jun;21(6):705-13. Epub 2009 May 21.PMID: 19461125 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection.

    Undlien DE, Friede T, Rammensee HG, Joner G, Dahl-Jørgensen K, Søvik O, Akselsen HE, Knutsen I, Rønningen KS, Thorsby E.

    Diabetes. 1997 Jan;46(1):143-9.PMID: 8971095 [PubMed - indexed for MEDLINE]Related articles

    18.

    GAD-reactive T cells were mainly detected in autoimmune-related type 1 diabetic patients with HLA DR9.

    Itoh A, Shimada A, Kodama K, Morimoto J, Suzuki R, Oikawa Y, Irie J, Nakagawa Y, Shigihara T, Kanazawa Y, Okubo Y, Motohashi Y, Maruyama T, Saruta T.

    Ann N Y Acad Sci. 2004 Dec;1037:33-40.PMID: 15699491 [PubMed - indexed for MEDLINE]Related articles

    19.

    Association between autoantibody markers and subtypes of DR4 and DR4-DQ in Swedish children with insulin-dependent diabetes reveals closer association of tyrosine pyrophosphatase autoimmunity with DR4 than DQ8.

    Sanjeevi CB, Hagopian WA, Landin-Olsson M, Kockum I, Woo W, Palmer JP, Lernmark A, Dahlquist G.

    Tissue Antigens. 1998 Mar;51(3):281-6.PMID: 9550329 [PubMed - indexed for MEDLINE]Related articles

    20.

    Heterozygosity for MICA5.0/MICA5.1 and HLA-DR3-DQ2/DR4-DQ8 are independent genetic risk factors for latent autoimmune diabetes in adults.

    Törn C, Gupta M, Nikitina Zake L, Sanjeevi CB, Landin-Olsson M.

    Hum Immunol. 2003 Sep;64(9):902-9.PMID: 12941547 [PubMed - indexed for MEDLINE]Related articles

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