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Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene.

Gray J, Yeo GS, Cox JJ, Morton J, Adlam AL, Keogh JM, Yanovski JA, El Gharbawy A, Han JC, Tung YC, Hodges JR, Raymond FL, O'rahilly S, Farooqi IS.

Diabetes. 2006 Dec;55(12):3366-71.PMID: 17130481 [PubMed - indexed for MEDLINE]Related articlesFree article

Brain-derived neurotrophic factor and obesity in the WAGR syndrome.

Han JC, Liu QR, Jones M, Levinn RL, Menzie CM, Jefferson-George KS, Adler-Wailes DC, Sanford EL, Lacbawan FL, Uhl GR, Rennert OM, Yanovski JA.

N Engl J Med. 2008 Aug 28;359(9):918-27. Erratum in: N Engl J Med. 2008 Sep 25;359(13):1414. PMID: 18753648 [PubMed - indexed for MEDLINE]Related articlesFree article

A mechanism underlying mature-onset obesity: evidence from the hyperphagic phenotype of brain-derived neurotrophic factor mutants.

Fox EA, Byerly MS.

Am J Physiol Regul Integr Comp Physiol. 2004 Jun;286(6):R994-1004.PMID: 15142855 [PubMed - indexed for MEDLINE]Related articles

Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder.

Friedel S, Horro FF, Wermter AK, Geller F, Dempfle A, Reichwald K, Smidt J, Brönner G, Konrad K, Herpertz-Dahlmann B, Warnke A, Hemminger U, Linder M, Kiefl H, Goldschmidt HP, Siegfried W, Remschmidt H, Hinney A, Hebebrand J.

Am J Med Genet B Neuropsychiatr Genet. 2005 Jan 5;132B(1):96-9.PMID: 15457498 [PubMed - indexed for MEDLINE]Related articles

Disruption of a novel regulatory locus results in decreased Bdnf expression, obesity, and type 2 diabetes in mice.

Sha H, Xu J, Tang J, Ding J, Gong J, Ge X, Kong D, Gao X.

Physiol Genomics. 2007 Oct 22;31(2):252-63. Epub 2007 Jul 24.PMID: 17652166 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of hyperphagia prevents obesity in BDNF heterozygous mice.

Coppola V, Tessarollo L.

Neuroreport. 2004 Dec 3;15(17):2665-8.PMID: 15570174 [PubMed - indexed for MEDLINE]Related articles

Association study of the decreased serum BDNF concentrations in amnestic mild cognitive impairment and the Val66Met polymorphism in Chinese Han.

Yu H, Zhang Z, Shi Y, Bai F, Xie C, Qian Y, Yuan Y, Deng L.

J Clin Psychiatry. 2008 Jul;69(7):1104-11.PMID: 18505307 [PubMed - indexed for MEDLINE]Related articles

Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity.

Unger TJ, Calderon GA, Bradley LC, Sena-Esteves M, Rios M.

J Neurosci. 2007 Dec 26;27(52):14265-74.PMID: 18160634 [PubMed - indexed for MEDLINE]Related articlesFree article

Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity.

Rios M, Fan G, Fekete C, Kelly J, Bates B, Kuehn R, Lechan RM, Jaenisch R.

Mol Endocrinol. 2001 Oct;15(10):1748-57.PMID: 11579207 [PubMed - indexed for MEDLINE]Related articlesFree article

A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism.

de Smith AJ, Purmann C, Walters RG, Ellis RJ, Holder SE, Van Haelst MM, Brady AF, Fairbrother UL, Dattani M, Keogh JM, Henning E, Yeo GS, O'Rahilly S, Froguel P, Farooqi IS, Blakemore AI.

Hum Mol Genet. 2009 Sep 1;18(17):3257-65. Epub 2009 Jun 4.PMID: 19498035 [PubMed - indexed for MEDLINE]Related articles

Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor.

Duan W, Guo Z, Jiang H, Ware M, Mattson MP.

Endocrinology. 2003 Jun;144(6):2446-53.PMID: 12746306 [PubMed - indexed for MEDLINE]Related articlesFree article

Brain-derived neurotrophic factor polymorphism Val66Met influences cognitive abilities in the elderly.

Miyajima F, Ollier W, Mayes A, Jackson A, Thacker N, Rabbitt P, Pendleton N, Horan M, Payton A.

Genes Brain Behav. 2008 Jun;7(4):411-7. Epub 2007 Oct 31.PMID: 17973920 [PubMed - indexed for MEDLINE]Related articles

Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage.

Tran PV, Akana SF, Malkovska I, Dallman MF, Parada LF, Ingraham HA.

J Comp Neurol. 2006 Oct 10;498(5):637-48.PMID: 16917842 [PubMed - indexed for MEDLINE]Related articles

Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities.

Lyons WE, Mamounas LA, Ricaurte GA, Coppola V, Reid SW, Bora SH, Wihler C, Koliatsos VE, Tessarollo L.

Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15239-44.PMID: 10611369 [PubMed - indexed for MEDLINE]Related articlesFree article

Brain-derived neurotrophic factor (BDNF) and type 2 diabetes.

Krabbe KS, Nielsen AR, Krogh-Madsen R, Plomgaard P, Rasmussen P, Erikstrup C, Fischer CP, Lindegaard B, Petersen AM, Taudorf S, Secher NH, Pilegaard H, Bruunsgaard H, Pedersen BK.

Diabetologia. 2007 Feb;50(2):431-8. Epub 2006 Dec 7.PMID: 17151862 [PubMed - indexed for MEDLINE]Related articles

Is autism caused by early hyperactivity of brain-derived neurotrophic factor?

Tsai SJ.

Med Hypotheses. 2005;65(1):79-82.PMID: 15893122 [PubMed - indexed for MEDLINE]Related articles

Opposite changes in the serum brain-derived neurotrophic factor in anorexia nervosa and obesity.

Monteleone P, Tortorella A, Martiadis V, Serritella C, Fuschino A, Maj M.

Psychosom Med. 2004 Sep-Oct;66(5):744-8.PMID: 15385700 [PubMed - indexed for MEDLINE]Related articlesFree article

Variant BDNF (Val66Met) impact on brain structure and function.

Bath KG, Lee FS.

Cogn Affect Behav Neurosci. 2006 Mar;6(1):79-85. Review.PMID: 16869232 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of brain-derived neurotrophic factor in eating disorders: recent findings and its pathophysiological implications.

Hashimoto K, Koizumi H, Nakazato M, Shimizu E, Iyo M.

Prog Neuropsychopharmacol Biol Psychiatry. 2005 May;29(4):499-504. Review.PMID: 15866349 [PubMed - indexed for MEDLINE]Related articles

Low plasma brain-derived neurotrophic factor and childhood physical neglect are associated with verbal memory impairment in major depression--a preliminary report.

Grassi-Oliveira R, Stein LM, Lopes RP, Teixeira AL, Bauer ME.

Biol Psychiatry. 2008 Aug 15;64(4):281-5. Epub 2008 Apr 11.PMID: 18406398 [PubMed - indexed for MEDLINE]Related articles