PubMed

Introgression of F344 rat genomic DNA on BB rat chromosome 4 generates diabetes-resistant lymphopenic BB rats.

Fuller JM, Kwitek AE, Hawkins TJ, Moralejo DH, Lu W, Tupling TD, Macmurray AJ, Borchardt G, Hasinoff M, Lernmark A.

Diabetes. 2006 Dec;55(12):3351-7. Erratum in: Diabetes. 2007 Feb;56(2):549. PMID: 17130479 [PubMed - indexed for MEDLINE]Related articlesFree article

Sequence variation and expression of the Gimap gene family in the BB rat.

Rutledge EA, Fuller JM, Van Yserloo B, Moralejo DH, Ettinger RA, Gaur P, Hoehna JL, Peterson MR, Jensen R, Kwitek AE, Lernmark A.

Exp Diabetes Res. 2009;2009:835650. Epub 2009 May 3.PMID: 19421422 [PubMed - indexed for MEDLINE]Related articlesFree article

BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2.

Klaff LS, Koike G, Jiang J, Wang Y, Bieg S, Pettersson A, Lander E, Jacob H, Lernmark A.

Mamm Genome. 1999 Sep;10(9):883-7.PMID: 10441739 [PubMed - indexed for MEDLINE]Related articles

Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene.

Fuller JM, Bogdani M, Tupling TD, Jensen RA, Pefley R, Manavi S, Cort L, Blankenhorn EP, Mordes JP, Lernmark A, Kwitek AE.

Physiol Genomics. 2009 Jun 10;38(1):89-97. Epub 2009 Apr 7.PMID: 19351909 [PubMed - indexed for MEDLINE]Related articles

Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.

Martin AM, Maxson MN, Leif J, Mordes JP, Greiner DL, Blankenhorn EP.

Diabetes. 1999 Nov;48(11):2138-44.PMID: 10535446 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat.

Moralejo DH, Park HA, Speros SJ, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A.

J Autoimmun. 2003 Dec;21(4):315-24.PMID: 14624755 [PubMed - indexed for MEDLINE]Related articles

DR.lyp/lyp bone marrow maintains lymphopenia and promotes diabetes in lyp/lyp but not in +/+ recipient DR.lyp BB rats.

Hawkins T, Fuller J, Olson K, Speros S, Lernmark A.

J Autoimmun. 2005 Dec;25(4):251-7. Epub 2005 Oct 24.PMID: 16246525 [PubMed - indexed for MEDLINE]Related articles

Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene.

MacMurray AJ, Moralejo DH, Kwitek AE, Rutledge EA, Van Yserloo B, Gohlke P, Speros SJ, Snyder B, Schaefer J, Bieg S, Jiang J, Ettinger RA, Fuller J, Daniels TL, Pettersson A, Orlebeke K, Birren B, Jacob HJ, Lander ES, Lernmark A.

Genome Res. 2002 Jul;12(7):1029-39.PMID: 12097339 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1 diabetes in the BB rat: a polygenic disease.

Wallis RH, Wang K, Marandi L, Hsieh E, Ning T, Chao GY, Sarmiento J, Paterson AD, Poussier P.

Diabetes. 2009 Apr;58(4):1007-17. Epub 2009 Jan 23.PMID: 19168599 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-density cells isolated from the rat thymus resemble branched cortical macrophages and have a reduced capability of rescuing double-positive thymocytes from apoptosis in the BB-DP rat.

Sommandas V, Rutledge EA, Van Yserloo B, Fuller J, Lernmark A, Drexhage HA.

J Leukoc Biol. 2007 Oct;82(4):869-76. Epub 2007 Jun 28.PMID: 17599904 [PubMed - indexed for MEDLINE]Related articlesFree article

Aberrancies in the differentiation and maturation of dendritic cells from bone-marrow precursors are linked to various genes on chromosome 4 and other chromosomes of the BB-DP rat.

Sommandas V, Rutledge EA, Van Yserloo B, Fuller J, Lernmark A, Drexhage HA.

J Autoimmun. 2005 Aug;25(1):1-12.PMID: 16023326 [PubMed - indexed for MEDLINE]Related articles

Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes.

Markholst H, Eastman S, Wilson D, Andreasen BE, Lernmark A.

J Exp Med. 1991 Jul 1;174(1):297-300.PMID: 2056281 [PubMed - indexed for MEDLINE]Related articlesFree article

Eosinophilic bowel disease controlled by the BB rat-derived lymphopenia/Gimap5 gene.

Cousins L, Graham M, Tooze R, Carter C, Miller JR, Powrie FM, Macpherson GG, Butcher GW.

Gastroenterology. 2006 Nov;131(5):1475-85. Epub 2006 Oct 5.PMID: 17064701 [PubMed - indexed for MEDLINE]Related articles

A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes.

Wallis RH, Wang K, Dabrowski D, Marandi L, Ning T, Hsieh E, Paterson AD, Mordes JP, Blankenhorn EP, Poussier P.

Diabetes. 2007 Jun;56(6):1731-6. Epub 2007 Mar 27.PMID: 17389329 [PubMed - indexed for MEDLINE]Related articlesFree article

Mapping of caspase-2 in the rat and its exclusion as a candidate gene for lymphopenia.

Hornum L, Rasmussen SB, Markholst H.

Mamm Genome. 1999 Mar;10(3):244-8.PMID: 10051319 [PubMed - indexed for MEDLINE]Related articles

Derivation of non-lymphopenic BB rats with an intercross breeding.

Herold KC, Kastern W, Markholst H, Lernmark A.

Autoimmunity. 1989;3(2):83-93.PMID: 2577492 [PubMed - indexed for MEDLINE]Related articles

Genetic studies in inbred BB/Wor rats. Analysis of progeny produced by crossing lymphopenic diabetes-prone rats with nonlymphopenic diabetic rats.

Guberski DL, Butler L, Kastern W, Like AA.

Diabetes. 1989 Jul;38(7):887-93.PMID: 2567683 [PubMed - indexed for MEDLINE]Related articles

Genetic dissection of autoimmune type I diabetes in the BB rat.

Jacob HJ, Pettersson A, Wilson D, Mao Y, Lernmark A, Lander ES.

Nat Genet. 1992 Sep;2(1):56-60. Erratum in: Nat Genet 1994 Jun;7(2):215. PMID: 1303251 [PubMed - indexed for MEDLINE]Related articles

Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding rat.

Geoffrey R, Jia S, Kwitek AE, Woodliff J, Ghosh S, Lernmark A, Wang X, Hessner MJ.

J Immunol. 2006 Nov 15;177(10):7275-86.PMID: 17082646 [PubMed - indexed for MEDLINE]Related articlesFree article

Thymectomy and radiation-induced type 1 diabetes in nonlymphopenic BB rats.

Ramanathan S, Bihoreau MT, Paterson AD, Marandi L, Gauguier D, Poussier P.

Diabetes. 2002 Oct;51(10):2975-81.PMID: 12351436 [PubMed - indexed for MEDLINE]Related articlesFree article