PubMed

Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth.

Miettinen PJ, Ustinov J, Ormio P, Gao R, Palgi J, Hakonen E, Juntti-Berggren L, Berggren PO, Otonkoski T.

Diabetes. 2006 Dec;55(12):3299-308.PMID: 17130473 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors.

Miettinen PJ, Huotari M, Koivisto T, Ustinov J, Palgi J, Rasilainen S, Lehtonen E, Keski-Oja J, Otonkoski T.

Development. 2000 Jun;127(12):2617-27.PMID: 10821760 [PubMed - indexed for MEDLINE]Related articlesFree article

ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture.

Huotari MA, Miettinen PJ, Palgi J, Koivisto T, Ustinov J, Harari D, Yarden Y, Otonkoski T.

Endocrinology. 2002 Nov;143(11):4437-46.PMID: 12399441 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia.

Means AL, Ray KC, Singh AB, Washington MK, Whitehead RH, Harris RC Jr, Wright CV, Coffey RJ Jr, Leach SD.

Gastroenterology. 2003 Apr;124(4):1020-36.PMID: 12671899 [PubMed - indexed for MEDLINE]Related articles

Regulation of pancreatic beta-cell mass and proliferation by SOCS-3.

Lindberg K, Rønn SG, Tornehave D, Richter H, Hansen JA, Rømer J, Jackerott M, Billestrup N.

J Mol Endocrinol. 2005 Oct;35(2):231-43.PMID: 16216905 [PubMed - indexed for MEDLINE]Related articlesFree article

EGF receptor in pancreatic beta-cell mass regulation.

Miettinen P, Ormio P, Hakonen E, Banerjee M, Otonkoski T.

Biochem Soc Trans. 2008 Jun;36(Pt 3):280-5. Review.PMID: 18481942 [PubMed - indexed for MEDLINE]Related articles

Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function.

Granata R, Settanni F, Gallo D, Trovato L, Biancone L, Cantaluppi V, Nano R, Annunziata M, Campiglia P, Arnoletti E, Ghè C, Volante M, Papotti M, Muccioli G, Ghigo E.

Diabetes. 2008 Apr;57(4):967-79. Epub 2007 Dec 27.PMID: 18162507 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function.

Park S, Dong X, Fisher TL, Dunn S, Omer AK, Weir G, White MF.

J Biol Chem. 2006 Jan 13;281(2):1159-68. Epub 2005 Nov 4.PMID: 16272563 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development.

Herbach N, Goeke B, Schneider M, Hermanns W, Wolf E, Wanke R.

Regul Pept. 2005 Feb 15;125(1-3):103-17.PMID: 15582721 [PubMed - indexed for MEDLINE]Related articles

Destruction of pancreatic beta-cells by transgenic induction of prostaglandin E2 in the islets.

Oshima H, Taketo MM, Oshima M.

J Biol Chem. 2006 Sep 29;281(39):29330-6. Epub 2006 Jul 27.PMID: 16873378 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo proliferation of differentiated pancreatic islet beta cells in transgenic mice expressing mutated cyclin-dependent kinase 4.

Hino S, Yamaoka T, Yamashita Y, Yamada T, Hata J, Itakura M.

Diabetologia. 2004 Oct;47(10):1819-30. Epub 2004 Oct 6.PMID: 15480536 [PubMed - indexed for MEDLINE]Related articles

Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells.

Tweedie E, Artner I, Crawford L, Poffenberger G, Thorens B, Stein R, Powers AC, Gannon M.

Diabetes. 2006 Dec;55(12):3264-70.PMID: 17130469 [PubMed - indexed for MEDLINE]Related articlesFree article

Glial cell line-derived neurotrophic factor increases beta-cell mass and improves glucose tolerance.

Mwangi S, Anitha M, Mallikarjun C, Ding X, Hara M, Parsadanian A, Larsen CP, Thule P, Sitaraman SV, Anania F, Srinivasan S.

Gastroenterology. 2008 Mar;134(3):727-37. Epub 2008 Feb 1.PMID: 18241861 [PubMed - indexed for MEDLINE]Related articles

Hypoplasia of pancreatic islets in transgenic mice expressing activin receptor mutants.

Yamaoka T, Idehara C, Yano M, Matsushita T, Yamada T, Ii S, Moritani M, Hata J, Sugino H, Noji S, Itakura M.

J Clin Invest. 1998 Jul 15;102(2):294-301.PMID: 9664070 [PubMed - indexed for MEDLINE]Related articlesFree article

Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells.

Bouzakri K, Ribaux P, Tomas A, Parnaud G, Rickenbach K, Halban PA.

Diabetes. 2008 May;57(5):1195-204. Epub 2008 Feb 14.PMID: 18276765 [PubMed - indexed for MEDLINE]Related articlesFree article

Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass.

Suarez-Pinzon WL, Lakey JR, Brand SJ, Rabinovitch A.

J Clin Endocrinol Metab. 2005 Jun;90(6):3401-9. Epub 2005 Mar 15.PMID: 15769977 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.

Gorogawa S, Fujitani Y, Kaneto H, Hazama Y, Watada H, Miyamoto Y, Takeda K, Akira S, Magnuson MA, Yamasaki Y, Kajimoto Y, Hori M.

Biochem Biophys Res Commun. 2004 Jul 9;319(4):1159-70.PMID: 15194489 [PubMed - indexed for MEDLINE]Related articles

Modulation of endocrine pancreas development but not beta-cell carcinogenesis by Sprouty4.

Jäggi F, Cabrita MA, Perl AK, Christofori G.

Mol Cancer Res. 2008 Mar;6(3):468-82.PMID: 18337453 [PubMed - indexed for MEDLINE]Related articlesFree article

The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass.

Zhang H, Ackermann AM, Gusarova GA, Lowe D, Feng X, Kopsombut UG, Costa RH, Gannon M.

Mol Endocrinol. 2006 Aug;20(8):1853-66. Epub 2006 Mar 23.PMID: 16556734 [PubMed - indexed for MEDLINE]Related articlesFree article

c-Kit in early onset of diabetes: a morphological and functional analysis of pancreatic beta-cells in c-KitW-v mutant mice.

Krishnamurthy M, Ayazi F, Li J, Lyttle AW, Woods M, Wu Y, Yee SP, Wang R.

Endocrinology. 2007 Nov;148(11):5520-30. Epub 2007 Aug 2.PMID: 17673521 [PubMed - indexed for MEDLINE]Related articlesFree article