PubMed

Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats.

Nascimento EB, Fodor M, van der Zon GC, Jazet IM, Meinders AE, Voshol PJ, Vlasblom R, Baan B, Eckel J, Maassen JA, Diamant M, Ouwens DM.

Diabetes. 2006 Dec;55(12):3221-8.PMID: 17130464 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary cod protein restores insulin-induced activation of phosphatidylinositol 3-kinase/Akt and GLUT4 translocation to the T-tubules in skeletal muscle of high-fat-fed obese rats.

Tremblay F, Lavigne C, Jacques H, Marette A.

Diabetes. 2003 Jan;52(1):29-37.PMID: 12502490 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.

Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH.

Nat Cell Biol. 2007 Mar;9(3):316-23. Epub 2007 Feb 4.PMID: 17277771 [PubMed - indexed for MEDLINE]Related articles

Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury.

Yu F, Narasimhan P, Saito A, Liu J, Chan PH.

J Cereb Blood Flow Metab. 2008 Jan;28(1):44-52. Epub 2007 Apr 25.PMID: 17457363 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis.

Huang B, Porter G.

Acta Pharmacol Sin. 2005 Oct;26(10):1253-8.PMID: 16174443 [PubMed - indexed for MEDLINE]Related articlesFree article

Both saturated and n-6 polyunsaturated fat diets reduce phosphorylation of insulin receptor substrate-1 and protein kinase B in muscle during the initial stages of in vivo insulin stimulation.

Frangioudakis G, Ye JM, Cooney GJ.

Endocrinology. 2005 Dec;146(12):5596-603. Epub 2005 Sep 8.PMID: 16150913 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-chain n-3 polyunsaturated fatty acids dissociate phosphorylation of Akt from phosphatidylinositol 3'-kinase activity in rats.

Le Foll C, Corporeau C, Le Guen V, Gouygou JP, Bergé JP, Delarue J.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1223-30. Epub 2006 Dec 19.PMID: 17179391 [PubMed - indexed for MEDLINE]Related articlesFree article

Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes.

Hinault C, Mothe-Satney I, Gautier N, Van Obberghen E.

Diabetologia. 2006 May;49(5):1017-26. Epub 2006 Mar 21.PMID: 16550357 [PubMed - indexed for MEDLINE]Related articles

Angiotensin-(1 7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors.

Giani JF, Gironacci MM, Muñoz MC, Peña C, Turyn D, Dominici FP.

Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H1154-63. Epub 2007 May 11.PMID: 17496209 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.

Wang L, Harris TE, Lawrence JC Jr.

J Biol Chem. 2008 Jun 6;283(23):15619-27. Epub 2008 Mar 27.PMID: 18372248 [PubMed - indexed for MEDLINE]Related articlesFree article

Adrenaline potentiates insulin-stimulated PKB activation in the rat fast-twitch epitrochlearis muscle without affecting IRS-1-associated PI 3-kinase activity.

Jensen J, Grønning-Wang LM, Jebens E, Whitehead JP, Zorec R, Shepherd PR.

Pflugers Arch. 2008 Aug;456(5):969-78. Epub 2008 Feb 26.PMID: 18299886 [PubMed - indexed for MEDLINE]Related articles

Identification of a proline-rich Akt substrate as a 14-3-3 binding partner.

Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA.

J Biol Chem. 2003 Mar 21;278(12):10189-94. Epub 2003 Jan 10.PMID: 12524439 [PubMed - indexed for MEDLINE]Related articlesFree article

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM.

Mol Cell. 2007 Mar 23;25(6):903-15.PMID: 17386266 [PubMed - indexed for MEDLINE]Related articles

Renal activity of Akt kinase in obese Zucker rats.

Zdychová J, Kazdová L, Pelikanová T, Lindsley JN, Anderson S, Komers R.

Exp Biol Med (Maywood). 2008 Oct;233(10):1231-41. Epub 2008 Jul 18.PMID: 18641049 [PubMed - indexed for MEDLINE]Related articlesFree article

Statin modulates insulin signaling and insulin resistance in liver and muscle of rats fed a high-fat diet.

Lalli CA, Pauli JR, Prada PO, Cintra DE, Ropelle ER, Velloso LA, Saad MJ.

Metabolism. 2008 Jan;57(1):57-65.PMID: 18078859 [PubMed - indexed for MEDLINE]Related articles

Analysis of complex protein kinase B signalling pathways in human prostate cancer samples.

Jendrossek V, Henkel M, Hennenlotter J, Vogel U, Ganswindt U, Müller I, Handrick R, Anastasiadis AG, Kuczyk M, Stenzl A, Belka C.

BJU Int. 2008 Aug;102(3):371-82. Epub 2008 May 12.PMID: 18476967 [PubMed - indexed for MEDLINE]Related articles

IGF-1 protects against dexamethasone-induced cell death in insulin secreting INS-1 cells independent of AKT/PKB phosphorylation.

Avram D, Ranta F, Hennige AM, Berchtold S, Hopp S, Häring HU, Lang F, Ullrich S.

Cell Physiol Biochem. 2008;21(5-6):455-62. Epub 2008 Apr 24.PMID: 18453753 [PubMed - indexed for MEDLINE]Related articles

Effect of estrogen and inhibition of phosphatidylinositol-3 kinase on Akt and FOXO1 in rat uterus.

Lengyel F, Vértes Z, Kovács KA, Környei JL, Sümegi B, Vértes M.

Steroids. 2007 May;72(5):422-8. Epub 2007 Mar 12.PMID: 17433823 [PubMed - indexed for MEDLINE]Related articles

Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification.

Ouwens DM, Diamant M, Fodor M, Habets DD, Pelsers MM, El Hasnaoui M, Dang ZC, van den Brom CE, Vlasblom R, Rietdijk A, Boer C, Coort SL, Glatz JF, Luiken JJ.

Diabetologia. 2007 Sep;50(9):1938-48. Epub 2007 Jul 18.PMID: 17639306 [PubMed - indexed for MEDLINE]Related articlesFree article

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.

Oshiro N, Takahashi R, Yoshino K, Tanimura K, Nakashima A, Eguchi S, Miyamoto T, Hara K, Takehana K, Avruch J, Kikkawa U, Yonezawa K.

J Biol Chem. 2007 Jul 13;282(28):20329-39. Epub 2007 May 21.PMID: 17517883 [PubMed - indexed for MEDLINE]Related articlesFree article