PubMed

Novel self-epitopes derived from aggrecan, fibrillin, and matrix metalloproteinase-3 drive distinct autoreactive T-cell responses in juvenile idiopathic arthritis and in health.

Kamphuis S, Hrafnkelsdóttir K, Klein MR, de Jager W, Haverkamp MH, van Bilsen JH, Albani S, Kuis W, Wauben MH, Prakken BJ.

Arthritis Res Ther. 2006;8(6):R178.PMID: 17129378 [PubMed - indexed for MEDLINE]Related articlesFree article

Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis.

Kamphuis S, Kuis W, de Jager W, Teklenburg G, Massa M, Gordon G, Boerhof M, Rijkers GT, Uiterwaal CS, Otten HG, Sette A, Albani S, Prakken BJ.

Lancet. 2005 Jul 2-8;366(9479):50-6.PMID: 15993233 [PubMed - indexed for MEDLINE]Related articles

Identification of self-epitopes recognized by T cells in rheumatoid arthritis demonstrates matrix metalloproteinases as a novel T cell target.

ter Steege J, Vianen M, van Bilsen J, Bijlsma J, Lafeber F, Wauben M.

J Rheumatol. 2003 Jun;30(6):1147-56.PMID: 12784383 [PubMed - indexed for MEDLINE]Related articles

Differential recognition of heat-shock protein dnaJ-derived epitopes by effector and Treg cells leads to modulation of inflammation in juvenile idiopathic arthritis.

Massa M, Passalia M, Manzoni SM, Campanelli R, Ciardelli L, Yung GP, Kamphuis S, Pistorio A, Meli V, Sette A, Prakken B, Martini A, Albani S.

Arthritis Rheum. 2007 May;56(5):1648-57.PMID: 17469159 [PubMed - indexed for MEDLINE]Related articlesFree article

The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing the regulatory cytokine interleukin-10.

de Kleer IM, Kamphuis SM, Rijkers GT, Scholtens L, Gordon G, De Jager W, Häfner R, van de Zee R, van Eden W, Kuis W, Prakken BJ.

Arthritis Rheum. 2003 Jul;48(7):2001-10.PMID: 12847694 [PubMed - indexed for MEDLINE]Related articlesFree article

Proinflammatory responses to self HLA epitopes are triggered by molecular mimicry to Epstein-Barr virus proteins in oligoarticular juvenile idiopathic arthritis.

Massa M, Mazzoli F, Pignatti P, De Benedetti F, Passalia M, Viola S, Samodal R, La Cava A, Giannoni F, Ollier W, Martini A, Albani S.

Arthritis Rheum. 2002 Oct;46(10):2721-9.PMID: 12384932 [PubMed - indexed for MEDLINE]Related articlesFree article

Response of Th17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis.

von Delwig A, Locke J, Robinson JH, Ng WF.

Arthritis Rheum. 2010 Jan;62(1):143-9.PMID: 20039419 [PubMed - indexed for MEDLINE]Related articles

Elevated concentrations of monocyte derived cytokines in synovial fluid of children with enthesitis related arthritis and polyarticular types of juvenile idiopathic arthritis.

Saxena N, Aggarwal A, Misra R.

J Rheumatol. 2005 Jul;32(7):1349-53.PMID: 15996076 [PubMed - indexed for MEDLINE]Related articles

Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases.

Agarwal S, Misra R, Aggarwal A.

J Rheumatol. 2008 Mar;35(3):515-9. Epub 2008 Jan 15.PMID: 18203309 [PubMed - indexed for MEDLINE]Related articles

Predominant cellular immune response to the cartilage autoantigenic G1 aggrecan in ankylosing spondylitis and rheumatoid arthritis.

Zou J, Zhang Y, Thiel A, Rudwaleit M, Shi SL, Radbruch A, Poole R, Braun J, Sieper J.

Rheumatology (Oxford). 2003 Jul;42(7):846-55. Epub 2003 Feb 28.PMID: 12730543 [PubMed - indexed for MEDLINE]Related articlesFree article

Selection of self-reactive peptides within human aggrecan by use of a HLA-DRB1*0401 peptide binding motif.

Boots AM, Verheijden GF, Schöningh R, van Staveren CJ, Bos E, Elewaut D, de Keyser F, Veys E, Joosten I, Rijnders AW.

J Autoimmun. 1997 Dec;10(6):569-78.PMID: 9451596 [PubMed - indexed for MEDLINE]Related articles

Cartilage proteoglycan aggrecan epitopes induce proinflammatory autoreactive T-cell responses in rheumatoid arthritis and osteoarthritis.

de Jong H, Berlo SE, Hombrink P, Otten HG, van Eden W, Lafeber FP, Heurkens AH, Bijlsma JW, Glant TT, Prakken BJ.

Ann Rheum Dis. 2010 Jan;69(1):255-62. Epub .PMID: 19213744 [PubMed - indexed for MEDLINE]Related articles

Differential recognition of altered peptide ligands distinguishes two functionally discordant (arthritogenic and nonarthritogenic) autoreactive T cell hybridoma clones.

Buzás EI, Hanyecz A, Murad Y, Hudecz F, Rajnavölgyi E, Mikecz K, Glant TT.

J Immunol. 2003 Sep 15;171(6):3025-33.PMID: 12960328 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis.

de Jager W, Vastert SJ, Beekman JM, Wulffraat NM, Kuis W, Coffer PJ, Prakken BJ.

Arthritis Rheum. 2009 Sep;60(9):2782-93.PMID: 19714583 [PubMed - indexed for MEDLINE]Related articles

Characterization of autoreactive T cells to the autoantigens heterogeneous nuclear ribonucleoprotein A2 (RA33) and filaggrin in patients with rheumatoid arthritis.

Fritsch R, Eselböck D, Skriner K, Jahn-Schmid B, Scheinecker C, Bohle B, Tohidast-Akrad M, Hayer S, Neumüller J, Pinol-Roma S, Smolen JS, Steiner G.

J Immunol. 2002 Jul 15;169(2):1068-76.PMID: 12097415 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix metalloproteinases as targets for the immune system during experimental arthritis.

van Bilsen JH, Wagenaar-Hilbers JP, Grosfeld-Stulemeijer MC, van der Cammen MJ, van Dijk ME, van Eden W, Wauben MH.

J Immunol. 2004 Apr 15;172(8):5063-8.PMID: 15067089 [PubMed - indexed for MEDLINE]Related articlesFree article

Oligoarticular and polyarticular JIA: epidemiology and pathogenesis.

Macaubas C, Nguyen K, Milojevic D, Park JL, Mellins ED.

Nat Rev Rheumatol. 2009 Nov;5(11):616-26. Epub 2009 Oct 6. Review.PMID: 19806151 [PubMed - indexed for MEDLINE]Related articles

Using biology of disease to understand and guide therapy of JIA.

Prakken BJ, Albani S.

Best Pract Res Clin Rheumatol. 2009 Oct;23(5):599-608. Review.PMID: 19853826 [PubMed - indexed for MEDLINE]Related articles

Th17 transcription factor RORC2 is inversely correlated with FOXP3 expression in the joints of children with juvenile idiopathic arthritis.

Olivito B, Simonini G, Ciullini S, Moriondo M, Betti L, Gambineri E, Cantarini L, De Martino M, Azzari C, Cimaz R.

J Rheumatol. 2009 Sep;36(9):2017-24. Epub 2009 Jul 31.PMID: 19648312 [PubMed - indexed for MEDLINE]Related articles

Elevated serum receptor activator of NFkappaB ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase (MMP)3, and ProMMP1 in patients with juvenile idiopathic arthritis.

Sarma PK, Misra R, Aggarwal A.

Clin Rheumatol. 2008 Mar;27(3):289-94. Epub 2007 Aug 17.PMID: 17703334 [PubMed - indexed for MEDLINE]Related articles