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    Results: 1 to 20 of 336

    1.

    A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells.

    Tarasov AI, Welters HJ, Senkel S, Ryffel GU, Hattersley AT, Morgan NG, Ashcroft FM.

    Diabetes. 2006 Nov;55(11):3075-82.PMID: 17065345 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Destabilization of ATP-sensitive potassium channel activity by novel KCNJ11 mutations identified in congenital hyperinsulinism.

    Lin YW, Bushman JD, Yan FF, Haidar S, MacMullen C, Ganguly A, Stanley CA, Shyng SL.

    J Biol Chem. 2008 Apr 4;283(14):9146-56. Epub 2008 Feb 4.PMID: 18250167 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes.

    Girard CA, Shimomura K, Proks P, Absalom N, Castano L, Perez de Nanclares G, Ashcroft FM.

    Pflugers Arch. 2006 Dec;453(3):323-32. Epub 2006 Sep 22.PMID: 17021801 [PubMed - indexed for MEDLINE]Related articles

    4.

    Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features.

    Proks P, Antcliff JF, Lippiat J, Gloyn AL, Hattersley AT, Ashcroft FM.

    Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17539-44. Epub 2004 Dec 6.PMID: 15583126 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Diabetes and hypoglycaemia in young children and mutations in the Kir6.2 subunit of the potassium channel: therapeutic consequences.

    Flechtner I, de Lonlay P, Polak M.

    Diabetes Metab. 2006 Dec;32(6):569-80. Review.PMID: 17296510 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Sulfonylurea receptor 1 mutations that cause opposite insulin secretion defects with chemical chaperone exposure.

    Pratt EB, Yan FF, Gay JW, Stanley CA, Shyng SL.

    J Biol Chem. 2009 Mar 20;284(12):7951-9. Epub 2009 Jan 16.PMID: 19151370 [PubMed - indexed for MEDLINE]Related articles

    7.

    Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy.

    Hattersley AT, Ashcroft FM.

    Diabetes. 2005 Sep;54(9):2503-13. Review.PMID: 16123337 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults.

    Tarasov AI, Nicolson TJ, Riveline JP, Taneja TK, Baldwin SA, Baldwin JM, Charpentier G, Gautier JF, Froguel P, Vaxillaire M, Rutter GA.

    Diabetes. 2008 Jun;57(6):1595-604. Epub 2008 Mar 17.PMID: 18346985 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Kir6.2 mutations associated with neonatal diabetes reduce expression of ATP-sensitive K+ channels: implications in disease mechanism and sulfonylurea therapy.

    Lin CW, Lin YW, Yan FF, Casey J, Kochhar M, Pratt EB, Shyng SL.

    Diabetes. 2006 Jun;55(6):1738-46.PMID: 16731837 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes.

    de Wet H, Rees MG, Shimomura K, Aittoniemi J, Patch AM, Flanagan SE, Ellard S, Hattersley AT, Sansom MS, Ashcroft FM.

    Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18988-92. Epub 2007 Nov 19.PMID: 18025464 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Functional effects of naturally occurring KCNJ11 mutations causing neonatal diabetes on cloned cardiac KATP channels.

    Tammaro P, Proks P, Ashcroft FM.

    J Physiol. 2006 Feb 15;571(Pt 1):3-14. Epub 2005 Dec 8.PMID: 16339180 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Focus on Kir6.2: a key component of the ATP-sensitive potassium channel.

    Haider S, Antcliff JF, Proks P, Sansom MS, Ashcroft FM.

    J Mol Cell Cardiol. 2005 Jun;38(6):927-36. Review.PMID: 15910877 [PubMed - indexed for MEDLINE]Related articles

    13.

    Diabetes in very young children and mutations in the insulin-secreting cell potassium channel genes: therapeutic consequences.

    Flechtner I, Vaxillaire M, Cavé H, Scharfmann R, Froguel P, Polak M.

    Endocr Dev. 2007;12:86-98.PMID: 17923772 [PubMed - indexed for MEDLINE]Related articles

    14.

    Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP.

    Proks P, Girard C, Ashcroft FM.

    Hum Mol Genet. 2005 Sep 15;14(18):2717-26. Epub 2005 Aug 8.PMID: 16087682 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Functional analysis of two Kir6.2 (KCNJ11) mutations, K170T and E322K, causing neonatal diabetes.

    Tarasov AI, Girard CA, Larkin B, Tammaro P, Flanagan SE, Ellard S, Ashcroft FM.

    Diabetes Obes Metab. 2007 Nov;9 Suppl 2:46-55.PMID: 17919178 [PubMed - indexed for MEDLINE]Related articles

    16.

    Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells.

    Moritz W, Leech CA, Ferrer J, Habener JF.

    Endocrinology. 2001 Jan;142(1):129-38.PMID: 11145575 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Functional effects of mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), causing neonatal diabetes, and response to sulfonylurea therapy.

    Proks P, Girard C, Baevre H, Njølstad PR, Ashcroft FM.

    Diabetes. 2006 Jun;55(6):1731-7.PMID: 16731836 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects.

    Shimomura K, Girard CA, Proks P, Nazim J, Lippiat JD, Cerutti F, Lorini R, Ellard S, Hattersley AT, Barbetti F, Ashcroft FM.

    Diabetes. 2006 Jun;55(6):1705-12. Erratum in: Diabetes. 2007 Mar;56(3):897. Hattersely, Andrew T [corrected to Hattersley, Andrew T]. PMID: 16731833 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    A Kir6.2 mutation causing severe functional effects in vitro produces neonatal diabetes without the expected neurological complications.

    Tammaro P, Flanagan SE, Zadek B, Srinivasan S, Woodhead H, Hameed S, Klimes I, Hattersley AT, Ellard S, Ashcroft FM.

    Diabetologia. 2008 May;51(5):802-10. Epub 2008 Mar 12.PMID: 18335204 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection.

    Koster JC, Permutt MA, Nichols CG.

    Diabetes. 2005 Nov;54(11):3065-72. Review.PMID: 16249427 [PubMed - indexed for MEDLINE]Related articlesFree article

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