PubMed

Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes.

Li X, Zhang L, Meshinchi S, Dias-Leme C, Raffin D, Johnson JD, Treutelaar MK, Burant CF.

Diabetes. 2006 Nov;55(11):2965-73.PMID: 17065332 [PubMed - indexed for MEDLINE]Related articlesFree article

Phlorizin treatment prevents the decrease in plasma insulin levels but not the progressive histopathological changes in the pancreatic islets during aging of Zucker diabetic fatty rats.

Janssen SW, Martens GJ, Sweep CG, Span PN, Verhofstad AA, Hermus AR.

J Endocrinol Invest. 2003 Jun;26(6):508-15.PMID: 12952363 [PubMed - indexed for MEDLINE]Related articles

Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat.

Tokuyama Y, Sturis J, DePaoli AM, Takeda J, Stoffel M, Tang J, Sun X, Polonsky KS, Bell GI.

Diabetes. 1995 Dec;44(12):1447-57.PMID: 7589853 [PubMed - indexed for MEDLINE]Related articles

Analysis of gene expression profiles in insulin-sensitive tissues from pre-diabetic and diabetic Zucker diabetic fatty rats.

Suh YH, Kim Y, Bang JH, Choi KS, Lee JW, Kim WH, Oh TJ, An S, Jung MH.

J Mol Endocrinol. 2005 Apr;34(2):299-315.PMID: 15821098 [PubMed - indexed for MEDLINE]Related articlesFree article

Low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of Zucker diabetic fatty rats.

MacDonald MJ, Tang J, Polonsky KS.

Diabetes. 1996 Nov;45(11):1626-30.PMID: 8866570 [PubMed - indexed for MEDLINE]Related articles

Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes.

Cockburn BN, Ostrega DM, Sturis J, Kubstrup C, Polonsky KS, Bell GI.

Diabetes. 1997 Sep;46(9):1434-9.PMID: 9287043 [PubMed - indexed for MEDLINE]Related articles

Modulation of adipoinsular axis in prediabetic zucker diabetic fatty rats by diazoxide.

Alemzadeh R, Tushaus KM.

Endocrinology. 2004 Dec;145(12):5476-84. Epub 2004 Aug 19.PMID: 15319354 [PubMed - indexed for MEDLINE]Related articlesFree article

Neointimal hyperplasia and vascular endothelial growth factor expression are increased in normoglycemic, insulin resistant, obese fatty rats.

Desouza CV, Gerety M, Hamel FG.

Atherosclerosis. 2006 Feb;184(2):283-9. Epub 2005 Jun 6.PMID: 15941566 [PubMed - indexed for MEDLINE]Related articles

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.

Shimabukuro M, Zhou YT, Levi M, Unger RH.

Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2498-502.PMID: 9482914 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix metalloproteinases contribute to insulin insufficiency in Zucker diabetic fatty rats.

Zhou YP, Madjidi A, Wilson ME, Nothhelfer DA, Johnson JH, Palma JF, Schweitzer A, Burant C, Blume JE, Johnson JD.

Diabetes. 2005 Sep;54(9):2612-9.PMID: 16123349 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.

Duvillié B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ.

Endocrinology. 2002 Apr;143(4):1530-7.PMID: 11897712 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.

Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, Polonsky KS.

Diabetes. 1998 Mar;47(3):358-64.PMID: 9519740 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion.

Wang MY, Koyama K, Shimabukuro M, Mangelsdorf D, Newgard CB, Unger RH.

Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11921-6.PMID: 9751766 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective fatty acid-mediated beta-cell compensation in Zucker diabetic fatty rats. Pathogenic implications for obesity-dependent diabetes.

Hirose H, Lee YH, Inman LR, Nagasawa Y, Johnson JH, Unger RH.

J Biol Chem. 1996 Mar 8;271(10):5633-7.PMID: 8621426 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death.

Finegood DT, McArthur MD, Kojwang D, Thomas MJ, Topp BG, Leonard T, Buckingham RE.

Diabetes. 2001 May;50(5):1021-9.PMID: 11334404 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial dysfunction as a modifier of angiogenic response in Zucker diabetic fat rat: amelioration with Ebselen.

Gealekman O, Brodsky SV, Zhang F, Chander PN, Friedli C, Nasjletti A, Goligorsky MS.

Kidney Int. 2004 Dec;66(6):2337-47.PMID: 15569324 [PubMed - indexed for MEDLINE]Related articles

Progressive histopathological changes in pancreatic islets of Zucker Diabetic Fatty rats.

Janssen SW, Hermus AR, Lange WP, Knijnenburg Q, van der Laak JA, Sweep CG, Martens GJ, Verhofstad AA.

Exp Clin Endocrinol Diabetes. 2001;109(5):273-82.PMID: 11507651 [PubMed - indexed for MEDLINE]Related articles

Podocyte injury promotes progressive nephropathy in zucker diabetic fatty rats.

Hoshi S, Shu Y, Yoshida F, Inagaki T, Sonoda J, Watanabe T, Nomoto K, Nagata M.

Lab Invest. 2002 Jan;82(1):25-35.PMID: 11796823 [PubMed - indexed for MEDLINE]Related articles

In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression.

Harmon JS, Gleason CE, Tanaka Y, Oseid EA, Hunter-Berger KK, Robertson RP.

Diabetes. 1999 Oct;48(10):1995-2000.PMID: 10512364 [PubMed - indexed for MEDLINE]Related articlesFree article

Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats.

Harmon JS, Gleason CE, Tanaka Y, Poitout V, Robertson RP.

Diabetes. 2001 Nov;50(11):2481-6.PMID: 11679425 [PubMed - indexed for MEDLINE]Related articlesFree article