PubMed

Expression of ATP-insensitive KATP channels in pancreatic beta-cells underlies a spectrum of diabetic phenotypes.

Koster JC, Remedi MS, Masia R, Patton B, Tong A, Nichols CG.

Diabetes. 2006 Nov;55(11):2957-64.PMID: 17065331 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted overactivity of beta cell K(ATP) channels induces profound neonatal diabetes.

Koster JC, Marshall BA, Ensor N, Corbett JA, Nichols CG.

Cell. 2000 Mar 17;100(6):645-54.PMID: 10761930 [PubMed - indexed for MEDLINE]Related articles

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.

Girard CA, Wunderlich FT, Shimomura K, Collins S, Kaizik S, Proks P, Abdulkader F, Clark A, Ball V, Zubcevic L, Bentley L, Clark R, Church C, Hugill A, Galvanovskis J, Cox R, Rorsman P, Brüning JC, Ashcroft FM.

J Clin Invest. 2009 Jan;119(1):80-90. doi: 10.1172/JCI35772. Epub 2008 Dec 8.PMID: 19065048 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cells.

Remedi MS, Nichols CG.

PLoS Med. 2008 Oct 28;5(10):e206.PMID: 18959471 [PubMed - indexed for MEDLINE]Related articlesFree article

Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus.

Remedi MS, Kurata HT, Scott A, Wunderlich FT, Rother E, Kleinridders A, Tong A, Brüning JC, Koster JC, Nichols CG.

Cell Metab. 2009 Feb;9(2):140-51.PMID: 19187772 [PubMed - indexed for MEDLINE]Related articles

Iptakalim, a vascular ATP-sensitive potassium (KATP) channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release.

Misaki N, Mao X, Lin YF, Suga S, Li GH, Liu Q, Chang Y, Wang H, Wakui M, Wu J.

J Pharmacol Exp Ther. 2007 Aug;322(2):871-8. Epub 2007 May 23.PMID: 17522344 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.

Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I.

J Biol Chem. 2006 Feb 24;281(8):5246-57. Epub 2005 Dec 23.PMID: 16377800 [PubMed - indexed for MEDLINE]Related articlesFree article

A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults.

Tarasov AI, Nicolson TJ, Riveline JP, Taneja TK, Baldwin SA, Baldwin JM, Charpentier G, Gautier JF, Froguel P, Vaxillaire M, Rutter GA.

Diabetes. 2008 Jun;57(6):1595-604. Epub 2008 Mar 17.PMID: 18346985 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose stimulates Ca2+ influx and insulin secretion in 2-week-old beta-cells lacking ATP-sensitive K+ channels.

Szollosi A, Nenquin M, Aguilar-Bryan L, Bryan J, Henquin JC.

J Biol Chem. 2007 Jan 19;282(3):1747-56. Epub 2006 Nov 30.PMID: 17138557 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired glucose sensitivity of ATP-sensitive K+ channels in pancreatic beta-cells in streptozotocin-induced NIDDM rats.

Tsuura Y, Ishida H, Okamoto Y, Tsuji K, Kurose T, Horie M, Imura H, Okada Y, Seino Y.

Diabetes. 1992 Jul;41(7):861-5.PMID: 1612201 [PubMed - indexed for MEDLINE]Related articles

Hyperinsulinism in mice with heterozygous loss of K(ATP) channels.

Remedi MS, Rocheleau JV, Tong A, Patton BL, McDaniel ML, Piston DW, Koster JC, Nichols CG.

Diabetologia. 2006 Oct;49(10):2368-78. Epub 2006 Aug 19.PMID: 16924481 [PubMed - indexed for MEDLINE]Related articles

ATP-sensitive K+ channel signaling in glucokinase-deficient diabetes.

Remedi MS, Koster JC, Patton BL, Nichols CG.

Diabetes. 2005 Oct;54(10):2925-31.PMID: 16186394 [PubMed - indexed for MEDLINE]Related articlesFree article

KATP channel-deficient pancreatic beta-cells are streptozotocin resistant because of lower GLUT2 activity.

Xu J, Zhang L, Chou A, Allaby T, Bélanger G, Radziuk J, Jasmin BJ, Miki T, Seino S, Renaud JM.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E326-35. Epub 2007 Nov 27.PMID: 18042662 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell hyperexcitability: from hyperinsulinism to diabetes.

Nichols CG, Koster JC, Remedi MS.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:81-8.PMID: 17919182 [PubMed - indexed for MEDLINE]Related articles

Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cells.

Nenquin M, Szollosi A, Aguilar-Bryan L, Bryan J, Henquin JC.

J Biol Chem. 2004 Jul 30;279(31):32316-24. Epub 2004 Jun 1.PMID: 15175349 [PubMed - indexed for MEDLINE]Related articlesFree article

Critical role of gap junction coupled KATP channel activity for regulated insulin secretion.

Rocheleau JV, Remedi MS, Granada B, Head WS, Koster JC, Nichols CG, Piston DW.

PLoS Biol. 2006 Feb;4(2):e26. Epub 2006 Jan 17.PMID: 16402858 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement.

Muñoz A, Hu M, Hussain K, Bryan J, Aguilar-Bryan L, Rajan AS.

Endocrinology. 2005 Dec;146(12):5514-21. Epub 2005 Aug 25.PMID: 16123162 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevation in intracellular long-chain acyl-coenzyme A esters lead to reduced beta-cell excitability via activation of adenosine 5'-triphosphate-sensitive potassium channels.

Webster NJ, Searle GJ, Lam PP, Huang YC, Riedel MJ, Harb G, Gaisano HY, Holt A, Light PE.

Endocrinology. 2008 Jul;149(7):3679-87. Epub 2008 Mar 27.PMID: 18372336 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose.

Ritzel RA, Hansen JB, Veldhuis JD, Butler PC.

J Clin Endocrinol Metab. 2004 Feb;89(2):795-805.PMID: 14764798 [PubMed - indexed for MEDLINE]Related articlesFree article

Diet-induced glucose intolerance in mice with decreased beta-cell ATP-sensitive K+ channels.

Remedi MS, Koster JC, Markova K, Seino S, Miki T, Patton BL, McDaniel ML, Nichols CG.

Diabetes. 2004 Dec;53(12):3159-67.PMID: 15561946 [PubMed - indexed for MEDLINE]Related articlesFree article