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    Results: 1 to 20 of 102

    1.

    A novel electron paramagnetic resonance-based assay for prostaglandin H synthase-1 activity.

    Turnbull CM, McClure D, Rossi AG, Megson IL.

    J Inflamm (Lond). 2006 Sep 28;3:12.PMID: 17007643 [PubMed]Related articlesFree article

    2.

    The analysis of nonsteroidal antiinflammatory drug selectivity in prostaglandin G/H synthase (PGHS)-null cells.

    Kirtikara K, Swangkul S, Ballou LR.

    Inflamm Res. 2001 Jun;50(6):327-32.PMID: 11475335 [PubMed - indexed for MEDLINE]Related articles

    3.

    Prostanoid production in Saccharomyces cerevisiae provides a novel assay for nonsteroidal anti-inflammatory drugs.

    Mohamed ME, Lazarus CM.

    FEMS Yeast Res. 2009 May;9(3):420-7. Epub 2009 Jan 21.PMID: 19207291 [PubMed - indexed for MEDLINE]Related articles

    4.

    Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells.

    Kargman S, Wong E, Greig GM, Falgueyret JP, Cromlish W, Ethier D, Yergey JA, Riendeau D, Evans JF, Kennedy B, Tagari P, Francis DA, O'Neill GP.

    Biochem Pharmacol. 1996 Oct 11;52(7):1113-25.PMID: 8831731 [PubMed - indexed for MEDLINE]Related articles

    5.

    Arachidonic acid and nonsteroidal anti-inflammatory drugs induce conformational changes in the human prostaglandin endoperoxide H2 synthase-2 (cyclooxygenase-2).

    Smith T, McCracken J, Shin YK, DeWitt D.

    J Biol Chem. 2000 Dec 22;275(51):40407-15. Retraction in: J Biol Chem. 2004 Feb 13;279(7):6204. PMID: 11006278 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2.

    Tsai AL, Palmer G, Wu G, Peng S, Okeley NM, van der Donk WA, Kulmacz RJ.

    J Biol Chem. 2002 Oct 11;277(41):38311-21. Epub 2002 Aug 6.PMID: 12167656 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Aromatic hydroxamic acids and hydrazides as inhibitors of the peroxidase activity of prostaglandin H2 synthase-2.

    Ouellet M, Aitken SM, English AM, Percival MD.

    Arch Biochem Biophys. 2004 Nov 1;431(1):107-18.PMID: 15464732 [PubMed - indexed for MEDLINE]Related articles

    8.

    Parallel synthesis and in vitro activity of novel anthranilic hydroxamate-based inhibitors of the prostaglandin H2 synthase peroxidase activity.

    Lee J, Chubb AJ, Moman E, McLoughlin BM, Sharkey CT, Kelly JG, Nolan KB, Devocelle M, Fitzgerald DJ.

    Org Biomol Chem. 2005 Oct 21;3(20):3678-85. Epub 2005 Sep 8.PMID: 16211102 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Prostaglandin-H-synthase (PGHS)-1 and -2 microtiter assays for the testing of herbal drugs and in vitro inhibition of PGHS-isoenzyms by polyunsaturated fatty acids from Platycodi radix.

    Reininger EA, Bauer R.

    Phytomedicine. 2006 Feb;13(3):164-9. Epub 2005 Sep 15.PMID: 16428023 [PubMed - indexed for MEDLINE]Related articles

    10.

    Identification of Tyr504 as an alternative tyrosyl radical site in human prostaglandin H synthase-2.

    Rogge CE, Liu W, Wu G, Wang LH, Kulmacz RJ, Tsai AL.

    Biochemistry. 2004 Feb 17;43(6):1560-8.PMID: 14769032 [PubMed - indexed for MEDLINE]Related articles

    11.

    Selective prostaglandin G/H synthase (PGHS)-2 inhibitors show greater inhibitory activities on human PGHS-2 than on murine PGHS-2 in intact cells.

    Berg J, Fellier H, Bodenteich A, Christoph T, Towart R.

    Inflammopharmacology. 1997;5(2):119-26.PMID: 17694360 [PubMed]Related articles

    12.

    Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.

    Aronoff DM, Boutaud O, Marnett LJ, Oates JA.

    J Pharmacol Exp Ther. 2003 Feb;304(2):589-95.PMID: 12538810 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms.

    Kawakami Y, Nakamura T, Hosokawa T, Suzuki-Yamamoto T, Yamashita H, Kimoto M, Tsuji H, Yoshida H, Hada T, Takahashi Y.

    Prostaglandins Leukot Essent Fatty Acids. 2009 May-Jun;80(5-6):239-45. Epub 2009 May 19.PMID: 19457650 [PubMed - indexed for MEDLINE]Related articles

    14.

    A computational protocol for the integration of the monotopic protein prostaglandin H2 synthase into a phospholipid bilayer.

    Fowler PW, Coveney PV.

    Biophys J. 2006 Jul 15;91(2):401-10. Epub 2006 Apr 21.PMID: 16632499 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Prostaglandin H synthases and their importance in chemical toxicity.

    Vogel C.

    Curr Drug Metab. 2000 Dec;1(4):391-404. Review.PMID: 11465045 [PubMed - indexed for MEDLINE]Related articles

    16.

    Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs.

    Byrns MC, Penning TM.

    Chem Biol Interact. 2009 Mar 16;178(1-3):221-7. Epub 2008 Nov 1.PMID: 19010312 [PubMed - indexed for MEDLINE]Related articles

    17.

    Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase.

    Bala M, Chin CN, Logan AT, Amin T, Marnett LJ, Boutaud O, Oates JA.

    Biochem Pharmacol. 2008 Apr 1;75(7):1472-81. Epub 2007 Dec 27.PMID: 18242581 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Oxyferryl heme and not tyrosyl radical is the likely culprit in prostaglandin H synthase-1 peroxidase inactivation.

    Wu G, Rogge CE, Wang JS, Kulmacz RJ, Palmer G, Tsai AL.

    Biochemistry. 2007 Jan 16;46(2):534-42.PMID: 17209563 [PubMed - indexed for MEDLINE]Related articles

    19.

    Role of Tyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitor interactions in prostaglandin H synthase-2.

    Rogge CE, Ho B, Liu W, Kulmacz RJ, Tsai AL.

    Biochemistry. 2006 Jan 17;45(2):523-32.PMID: 16401081 [PubMed - indexed for MEDLINE]Related articles

    20.

    Involvement of phospholipid hydroperoxide glutathione peroxidase in the modulation of prostaglandin D2 synthesis.

    Sakamoto H, Imai H, Nakagawa Y.

    J Biol Chem. 2000 Dec 22;275(51):40028-35.PMID: 11010961 [PubMed - indexed for MEDLINE]Related articlesFree article

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