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    Results: 1 to 20 of 239

    1.

    Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice.

    Sørensen H, Brand CL, Neschen S, Holst JJ, Fosgerau K, Nishimura E, Shulman GI.

    Diabetes. 2006 Oct;55(10):2843-8.PMID: 17003351 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice.

    Moritoh Y, Takeuchi K, Asakawa T, Kataoka O, Odaka H.

    Eur J Pharmacol. 2008 Jul 7;588(2-3):325-32. Epub 2008 Apr 10.PMID: 18499100 [PubMed - indexed for MEDLINE]Related articles

    3.

    Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis.

    Lee YS, Shin S, Shigihara T, Hahm E, Liu MJ, Han J, Yoon JW, Jun HS.

    Diabetes. 2007 Jun;56(6):1671-9. Epub 2007 Mar 16.PMID: 17369525 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Somatostatin receptor subtype-2-deficient mice with diet-induced obesity have hyperglycemia, nonfasting hyperglucagonemia, and decreased hepatic glycogen deposition.

    Singh V, Grötzinger C, Nowak KW, Zacharias S, Göncz E, Pless G, Sauer IM, Eichhorn I, Pfeiffer-Guglielmi B, Hamprecht B, Wiedenmann B, Plöckinger U, Strowski MZ.

    Endocrinology. 2007 Aug;148(8):3887-99. Epub 2007 May 24.PMID: 17525126 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Increased responsiveness to the hyperglycemic, hyperglucagonemic and hyperinsulinemic effects of circulating norepinephrine in ob/ob mice.

    Liang Y, Cincotta AH.

    Int J Obes Relat Metab Disord. 2001 May;25(5):698-704.PMID: 11360153 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia.

    Gu W, Yan H, Winters KA, Komorowski R, Vonderfecht S, Atangan L, Sivits G, Hill D, Yang J, Bi V, Shen Y, Hu S, Boone T, Lindberg RA, Véniant MM.

    J Pharmacol Exp Ther. 2009 Dec;331(3):871-81. Epub 2009 Aug 31.PMID: 19720878 [PubMed - in process]Related articles

    7.

    Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice.

    Tonra JR, Ono M, Liu X, Garcia K, Jackson C, Yancopoulos GD, Wiegand SJ, Wong V.

    Diabetes. 1999 Mar;48(3):588-94.PMID: 10078561 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Antihyperglycemic action of guanidinoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic KKAy and C57BL6Job/ob mice and increases glucose disappearance in rhesus monkeys.

    Meglasson MD, Wilson JM, Yu JH, Robinson DD, Wyse BM, de Souza CJ.

    J Pharmacol Exp Ther. 1993 Sep;266(3):1454-62.PMID: 8371149 [PubMed - indexed for MEDLINE]Related articles

    9.

    Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3.

    Gao H, Bryzgalova G, Hedman E, Khan A, Efendic S, Gustafsson JA, Dahlman-Wright K.

    Mol Endocrinol. 2006 Jun;20(6):1287-99. Epub 2006 Apr 20.PMID: 16627594 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity.

    Berglund ED, Li CY, Bina HA, Lynes SE, Michael MD, Shanafelt AB, Kharitonenkov A, Wasserman DH.

    Endocrinology. 2009 Sep;150(9):4084-93. Epub 2009 May 21.PMID: 19470704 [PubMed - indexed for MEDLINE]Related articles

    11.

    Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle.

    Kaidanovich-Beilin O, Eldar-Finkelman H.

    J Pharmacol Exp Ther. 2006 Jan;316(1):17-24. Epub 2005 Sep 16.PMID: 16169938 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Effects of glucagon and insulin on fatty acid synthesis and glycogen degradation in the perfused liver of normal and genetically obese (ob/ob) mice.

    Ma GY, Gove CD, Hems DA.

    Biochem J. 1978 Sep 15;174(3):761-8.PMID: 31866 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice.

    Ae Park S, Choi MS, Cho SY, Seo JS, Jung UJ, Kim MJ, Sung MK, Park YB, Lee MK.

    Life Sci. 2006 Aug 15;79(12):1207-13. Epub 2006 Mar 27.PMID: 16647724 [PubMed - indexed for MEDLINE]Related articles

    14.

    Sources of plasma glucose and liver glycogen in fasted ob/ob mice.

    Turner SM, Linfoot PA, Neese RA, Hellerstein MK.

    Acta Diabetol. 2005 Dec;42(4):187-93.PMID: 16382307 [PubMed - indexed for MEDLINE]Related articles

    15.

    Mechanisms of postabsorptive hyperglycemia in streptozotocin diabetic rats.

    Wi JK, Kim JK, Youn JH.

    Am J Physiol. 1996 May;270(5 Pt 1):E752-8.PMID: 8967462 [PubMed - indexed for MEDLINE]Related articles

    16.

    Hepatic drug metabolism and the activities of NADPH generating enzymes and glucose-6-phosphatase in phenobarbital treated genetically obese (ob/ob) mice.

    Stengard JH, Saarni HU, Karvonen RI, Lahtela JT, Kärki NT, Stenbäck F, Sotaniemi EA.

    Biomed Pharmacother. 1987;41(7):389-96.PMID: 2833324 [PubMed - indexed for MEDLINE]Related articles

    17.

    Antisense oligonucleotides targeted against glucocorticoid receptor reduce hepatic glucose production and ameliorate hyperglycemia in diabetic mice.

    Liang Y, Osborne MC, Monia BP, Bhanot S, Watts LM, She P, DeCarlo SO, Chen X, Demarest K.

    Metabolism. 2005 Jul;54(7):848-55.PMID: 15988691 [PubMed - indexed for MEDLINE]Related articles

    18.

    Immunoneutralization of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycaemia in moderately streptozotocin-diabetic rats.

    Brand CL, Rolin B, Jørgensen PN, Svendsen I, Kristensen JS, Holst JJ.

    Diabetologia. 1994 Oct;37(10):985-93.PMID: 7851693 [PubMed - indexed for MEDLINE]Related articles

    19.

    Liver-selective glucocorticoid receptor antagonism decreases glucose production and increases glucose disposal, ameliorating insulin resistance.

    Zinker B, Mika A, Nguyen P, Wilcox D, Ohman L, von Geldern TW, Opgenorth T, Jacobson P.

    Metabolism. 2007 Mar;56(3):380-7.PMID: 17292727 [PubMed - indexed for MEDLINE]Related articles

    20.

    Chromium alleviates glucose intolerance, insulin resistance, and hepatic ER stress in obese mice.

    Sreejayan N, Dong F, Kandadi MR, Yang X, Ren J.

    Obesity (Silver Spring). 2008 Jun;16(6):1331-7. Epub 2008 Apr 3.PMID: 18388893 [PubMed - indexed for MEDLINE]Related articles

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