PubMed

Identification of insulin signaling elements in human beta-cells: autocrine regulation of insulin gene expression.

Muller D, Huang GC, Amiel S, Jones PM, Persaud SJ.

Diabetes. 2006 Oct;55(10):2835-42.PMID: 17003350 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans.

Hribal ML, Perego L, Lovari S, Andreozzi F, Menghini R, Perego C, Finzi G, Usellini L, Placidi C, Capella C, Guzzi V, Lauro D, Bertuzzi F, Davalli A, Pozza G, Pontiroli A, Federici M, Lauro R, Brunetti A, Folli F, Sesti G.

FASEB J. 2003 Jul;17(10):1340-2. Epub 2003 May 8.PMID: 12738810 [PubMed - indexed for MEDLINE]Related articlesFree article

Progesterone receptor-B regulation of insulin-like growth factor-stimulated cell migration in breast cancer cells via insulin receptor substrate-2.

Ibrahim YH, Byron SA, Cui X, Lee AV, Yee D.

Mol Cancer Res. 2008 Sep;6(9):1491-8.PMID: 18819936 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.

Ohsugi M, Cras-Méneur C, Zhou Y, Bernal-Mizrachi E, Johnson JD, Luciani DS, Polonsky KS, Permutt MA.

J Biol Chem. 2005 Feb 11;280(6):4992-5003. Epub 2004 Nov 15.PMID: 15546857 [PubMed - indexed for MEDLINE]Related articlesFree article

Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function.

Granata R, Settanni F, Gallo D, Trovato L, Biancone L, Cantaluppi V, Nano R, Annunziata M, Campiglia P, Arnoletti E, Ghè C, Volante M, Papotti M, Muccioli G, Ghigo E.

Diabetes. 2008 Apr;57(4):967-79. Epub 2007 Dec 27.PMID: 18162507 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression heterogeneity in human islet endocrine cells in vitro: the insulin signalling cascade.

Muller D, Huang GC, Amiel S, Jones PM, Persaud SJ.

Diabetologia. 2007 Jun;50(6):1239-42. Epub 2007 Apr 18.PMID: 17440705 [PubMed - indexed for MEDLINE]Related articles

Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells.

Bouzakri K, Ribaux P, Tomas A, Parnaud G, Rickenbach K, Halban PA.

Diabetes. 2008 May;57(5):1195-204. Epub 2008 Feb 14.PMID: 18276765 [PubMed - indexed for MEDLINE]Related articlesFree article

Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.

Gonzalez-Rodriguez A, Clampit JE, Escribano O, Benito M, Rondinone CM, Valverde AM.

Endocrinology. 2007 Feb;148(2):594-608. Epub 2006 Oct 26.PMID: 17068137 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin signalling in islets.

Persaud SJ, Muller D, Jones PM.

Biochem Soc Trans. 2008 Jun;36(Pt 3):290-3.PMID: 18481944 [PubMed - indexed for MEDLINE]Related articles

Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.

Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G.

Endocrinology. 2007 Feb;148(2):512-29. Epub 2006 Oct 26.PMID: 17068144 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function.

Park S, Dong X, Fisher TL, Dunn S, Omer AK, Weir G, White MF.

J Biol Chem. 2006 Jan 13;281(2):1159-68. Epub 2005 Nov 4.PMID: 16272563 [PubMed - indexed for MEDLINE]Related articlesFree article

miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells.

El Ouaamari A, Baroukh N, Martens GA, Lebrun P, Pipeleers D, van Obberghen E.

Diabetes. 2008 Oct;57(10):2708-17. Epub 2008 Jun 30.PMID: 18591395 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5.

Su X, Lodhi IJ, Saltiel AR, Stahl PD.

J Biol Chem. 2006 Sep 22;281(38):27982-90. Epub 2006 Jul 31.PMID: 16880210 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells.

Harbeck MC, Louie DC, Howland J, Wolf BA, Rothenberg PL.

Diabetes. 1996 Jun;45(6):711-7.PMID: 8635642 [PubMed - indexed for MEDLINE]Related articles

Novel role for insulin as an autocrine growth factor for malignant brain tumour cells.

Arcaro A, Doepfner KT, Boller D, Guerreiro AS, Shalaby T, Jackson SP, Schoenwaelder SM, Delattre O, Grotzer MA, Fischer B.

Biochem J. 2007 Aug 15;406(1):57-66.PMID: 17506723 [PubMed - indexed for MEDLINE]Related articlesFree article

Cross down-regulation of leptin and insulin receptor expression and signalling in a human neuronal cell line.

Benomar Y, Roy AF, Aubourg A, Djiane J, Taouis M.

Biochem J. 2005 Jun 15;388(Pt 3):929-39.PMID: 15715521 [PubMed - indexed for MEDLINE]Related articlesFree article

Dehydroepiandrosterone increases beta-cell mass and improves the glucose-induced insulin secretion by pancreatic islets from aged rats.

Medina MC, Souza LC, Caperuto LC, Anhê GF, Amanso AM, Teixeira VP, Bordin S, Carpinelli AR, Britto LR, Barbieri RL, Borella MI, Carvalho CR.

FEBS Lett. 2006 Jan 9;580(1):285-90. Epub 2005 Dec 19. Erratum in: FEBS Lett. 2006 Feb 20;580(5):1528. PMID: 16376341 [PubMed - indexed for MEDLINE]Related articles

Insulin receptor signaling in the beta-cell influences insulin gene expression and insulin content: evidence for autocrine beta-cell regulation.

Xu GG, Rothenberg PL.

Diabetes. 1998 Aug;47(8):1243-52.PMID: 9703324 [PubMed - indexed for MEDLINE]Related articlesFree article

[The expression of insulin signal transduction molecules and islet alpha cell insulin resistance]

Du RQ, Li HL, Yang WY, Xiao JZ, Lou DJ, Wang B, Bai XP, Pan L.

Zhonghua Yi Xue Za Zhi. 2006 Sep 26;86(36):2542-6. Chinese. PMID: 17198562 [PubMed - indexed for MEDLINE]Related articles

Activated AKT/PKB signaling in C. elegans uncouples temporally distinct outputs of DAF-2/insulin-like signaling.

Gami MS, Iser WB, Hanselman KB, Wolkow CA.

BMC Dev Biol. 2006 Oct 4;6:45.PMID: 17020605 [PubMed - indexed for MEDLINE]Related articlesFree article