PubMed

A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy.

Sun W, Oates PJ, Coutcher JB, Gerhardinger C, Lorenzi M.

Diabetes. 2006 Oct;55(10):2757-62.PMID: 17003340 [PubMed - indexed for MEDLINE]Related articlesFree article

An aldose reductase inhibitor and aminoguanidine prevent vascular endothelial growth factor expression in rats with long-term galactosemia.

Frank RN, Amin R, Kennedy A, Hohman TC.

Arch Ophthalmol. 1997 Aug;115(8):1036-47.PMID: 9258227 [PubMed - indexed for MEDLINE]Related articles

A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat.

Asnaghi V, Gerhardinger C, Hoehn T, Adeboje A, Lorenzi M.

Diabetes. 2003 Feb;52(2):506-11.PMID: 12540628 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic-like retinopathy ameliorated with the aldose reductase inhibitor WAY-121,509.

Robinson WG Jr, Laver NM, Jacot JL, Glover JP, Basso MD, Blouin P, Hohman TC.

Invest Ophthalmol Vis Sci. 1996 May;37(6):1149-56.PMID: 8631629 [PubMed - indexed for MEDLINE]Related articlesFree article

Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis.

Drel VR, Pacher P, Ali TK, Shin J, Julius U, El-Remessy AB, Obrosova IG.

Int J Mol Med. 2008 Jun;21(6):667-76.PMID: 18506358 [PubMed - indexed for MEDLINE]Related articlesFree article

Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats.

Obrosova IG, Minchenko AG, Vasupuram R, White L, Abatan OI, Kumagai AK, Frank RN, Stevens MJ.

Diabetes. 2003 Mar;52(3):864-71.PMID: 12606532 [PubMed - indexed for MEDLINE]Related articlesFree article

The effects of an aldose reductase inhibitor upon the sorbitol pathway, fructose-1-phosphate and lactate in the retina and nerve of streptozotocin-diabetic rats.

Poulsom R, Mirrlees DJ, Earl DC, Heath H.

Exp Eye Res. 1983 May;36(5):751-60.PMID: 6406254 [PubMed - indexed for MEDLINE]Related articles

Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy.

Dagher Z, Park YS, Asnaghi V, Hoehn T, Gerhardinger C, Lorenzi M.

Diabetes. 2004 Sep;53(9):2404-11.PMID: 15331552 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic-like retinopathy: early and late intervention therapies in galactose-fed rats.

Robison WG Jr, Jacot JL, Glover JP, Basso MD, Hohman TC.

Invest Ophthalmol Vis Sci. 1998 Sep;39(10):1933-41.PMID: 9727416 [PubMed - indexed for MEDLINE]Related articlesFree article

An aldose reductase inhibitor, TAT, prevents electroretinographic abnormalities and ADP-induced hyperaggregability in streptozotocin-induced diabetic rats.

Hotta N, Koh N, Sakakibara F, Nakamura J, Hamada Y, Hara T, Takeuchi N, Inukai S, Kasama N, Fukasawa H, et al.

Eur J Clin Invest. 1995 Dec;25(12):948-54.PMID: 8719936 [PubMed - indexed for MEDLINE]Related articles

Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats.

Kador PF, Lee JW, Fujisawa S, Blessing K, Lou MF.

J Ocul Pharmacol Ther. 2000 Apr;16(2):149-60.PMID: 10803425 [PubMed - indexed for MEDLINE]Related articles

Long-term treatment with fidarestat suppresses the development of diabetic retinopathy in STZ-induced diabetic rats.

Kato N, Yashima S, Suzuki T, Nakayama Y, Jomori T.

J Diabetes Complications. 2003 Nov-Dec;17(6):374-9.PMID: 14583184 [PubMed - indexed for MEDLINE]Related articles

Effect of SG-210, a novel aldose reductase inhibitor, on impaired polyol pathway in rats received diabetic manipulations.

Horie S, Nagai H, Yuuki T, Narita Y, Tsuda Y, Nakajima T, Nakamura N.

J Diabetes Complications. 1998 May-Jun;12(3):163-9.PMID: 9618072 [PubMed - indexed for MEDLINE]Related articles

The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient.

Lorenzi M.

Exp Diabetes Res. 2007;2007:61038. Review.PMID: 18224243 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of an aldose reductase inhibitor, SNK-860, on the histopathological changes of retinal tissues in a streptozotocin-induced diabetic rat model.

Akita M, Mizuno K, Matsubara A, Nakano K, Kurono M.

Acta Med Okayama. 1993 Oct;47(5):299-304.PMID: 8273453 [PubMed - indexed for MEDLINE]Related articles

Prevention of diabetes-related retinal microangiopathy with aldose reductase inhibitors.

Robison WG Jr.

Adv Exp Med Biol. 1988;246:365-72. Review.PMID: 3150650 [PubMed - indexed for MEDLINE]Related articles

Aldose reductase: a window to the treatment of diabetic complications?

Crabbe MJ, Goode D.

Prog Retin Eye Res. 1998 Jul;17(3):313-83. Review.PMID: 9695797 [PubMed - indexed for MEDLINE]Related articles

Effect of an aldose reductase inhibitor on abnormalities of electroretinogram and vascular factors in diabetic rats.

Hotta N, Koh N, Sakakibara F, Nakamura J, Hara T, Hamada Y, Fukasawa H, Kakuta H, Sakamoto N.

Eur J Pharmacol. 1997 May 12;326(1):45-51.PMID: 9178654 [PubMed - indexed for MEDLINE]Related articles

Diabetes-related histopathologies of the rat retina prevented with an aldose reductase inhibitor.

Robison WG Jr, Tillis TN, Laver N, Kinoshita JH.

Exp Eye Res. 1990 Apr;50(4):355-66.PMID: 2110907 [PubMed - indexed for MEDLINE]Related articles

Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1.

Malamas MS, Hohman TC, Millen J.

J Med Chem. 1994 Jun 24;37(13):2043-58.PMID: 8027986 [PubMed - indexed for MEDLINE]Related articles