PubMed

Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation.

Vatamaniuk MZ, Gupta RK, Lantz KA, Doliba NM, Matschinsky FM, Kaestner KH.

Diabetes. 2006 Oct;55(10):2730-6.PMID: 17003337 [PubMed - indexed for MEDLINE]Related articlesFree article

cAMP-mediated signaling normalizes glucose-stimulated insulin secretion in uncoupling protein-2 overexpressing beta-cells.

McQuaid TS, Saleh MC, Joseph JW, Gyulkhandanyan A, Manning-Fox JE, MacLellan JD, Wheeler MB, Chan CB.

J Endocrinol. 2006 Sep;190(3):669-80.PMID: 17003268 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.

Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I.

J Biol Chem. 2006 Feb 24;281(8):5246-57. Epub 2005 Dec 23.PMID: 16377800 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.

Pongratz RL, Kibbey RG, Kirkpatrick CL, Zhao X, Pontoglio M, Yaniv M, Wollheim CB, Shulman GI, Cline GW.

J Biol Chem. 2009 Jun 19;284(25):16808-21. Epub 2009 Apr 17.PMID: 19376774 [PubMed - indexed for MEDLINE]Related articles

Regulation of insulin secretion by uncoupling protein.

Chan CB, Kashemsant N.

Biochem Soc Trans. 2006 Nov;34(Pt 5):802-5.PMID: 17052202 [PubMed - indexed for MEDLINE]Related articles

Endogenous islet uncoupling protein-2 expression and loss of glucose homeostasis in ob/ob mice.

Saleh MC, Wheeler MB, Chan CB.

J Endocrinol. 2006 Sep;190(3):659-67.PMID: 17003267 [PubMed - indexed for MEDLINE]Related articlesFree article

Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.

Produit-Zengaffinen N, Davis-Lameloise N, Perreten H, Bécard D, Gjinovci A, Keller PA, Wollheim CB, Herrera P, Muzzin P, Assimacopoulos-Jeannet F.

Diabetologia. 2007 Jan;50(1):84-93. Epub 2006 Nov 28.PMID: 17131143 [PubMed - indexed for MEDLINE]Related articles

On the role of uncoupling protein-2 in pancreatic beta cells.

Affourtit C, Brand MD.

Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):973-9. Epub 2008 Apr 3. Review.PMID: 18433713 [PubMed - indexed for MEDLINE]Related articles

Selective loss of glucose-induced amplification of insulin secretion in mouse pancreatic islets pretreated with sulfonylurea in the absence of fuels.

Urban KA, Panten U.

Diabetologia. 2005 Dec;48(12):2563-6. Epub 2005 Nov 11.PMID: 16283243 [PubMed - indexed for MEDLINE]Related articles

Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action.

De Souza CT, Araújo EP, Stoppiglia LF, Pauli JR, Ropelle E, Rocco SA, Marin RM, Franchini KG, Carvalheira JB, Saad MJ, Boschero AC, Carneiro EM, Velloso LA.

FASEB J. 2007 Apr;21(4):1153-63. Epub 2007 Jan 5.PMID: 17209127 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement.

Muñoz A, Hu M, Hussain K, Bryan J, Aguilar-Bryan L, Rajan AS.

Endocrinology. 2005 Dec;146(12):5514-21. Epub 2005 Aug 25.PMID: 16123162 [PubMed - indexed for MEDLINE]Related articlesFree article

UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival.

Diao J, Allister EM, Koshkin V, Lee SC, Bhattacharjee A, Tang C, Giacca A, Chan CB, Wheeler MB.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12057-62. Epub 2008 Aug 13.PMID: 18701716 [PubMed - indexed for MEDLINE]Related articlesFree article

Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function.

Pi J, Bai Y, Daniel KW, Liu D, Lyght O, Edelstein D, Brownlee M, Corkey BE, Collins S.

Endocrinology. 2009 Jul;150(7):3040-8. Epub 2009 Feb 26.PMID: 19246534 [PubMed - indexed for MEDLINE]Related articles

Enhancing effect of taurine on glucose response in UCP2-overexpressing beta cells.

Lee SH, Lee HY, Kim SY, Lee IK, Song DK.

Diabetes Res Clin Pract. 2004 Dec;66 Suppl 1:S69-74. Erratum in: Diabetes Res Clin Pract. 2005 Apr;68(1):84. Sang-Hoon, Lee [corrected to Lee, Sang-Hoon]; Hyun-Young, Lee [corrected to Lee, Hyun-Young]; So-Yeon, Kim [corrected to Kim, So-Yeon]; In-Kyu, Lee [corrected to Lee, In-Kyu]; Dae-Kyu, Song [corrected to Song, Dae-Kyu]. PMID: 15563984 [PubMed - indexed for MEDLINE]Related articles

Overexpression of short heterodimer partner recovers impaired glucose-stimulated insulin secretion of pancreatic beta-cells overexpressing UCP2.

Suh YH, Kim SY, Lee HY, Jang BC, Bae JH, Sohn JN, Bae JH, Suh SI, Park JW, Lee KU, Song DK.

J Endocrinol. 2004 Oct;183(1):133-44.PMID: 15525581 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced insulin secretion and content in VEGF-a deficient mouse pancreatic islets.

Jabs N, Franklin I, Brenner MB, Gromada J, Ferrara N, Wollheim CB, Lammert E.

Exp Clin Endocrinol Diabetes. 2008 Sep;116 Suppl 1:S46-9. Epub 2008 Sep 5.PMID: 18777454 [PubMed - indexed for MEDLINE]Related articles

beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels.

Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS.

Diabetes. 2007 Oct;56(10):2569-78. Epub 2007 Aug 8.PMID: 17686943 [PubMed - indexed for MEDLINE]Related articlesFree article

Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets.

Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA Jr, Lowell BB.

Cell Metab. 2006 Jun;3(6):417-27.PMID: 16753577 [PubMed - indexed for MEDLINE]Related articles

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F.

Diabetes. 2001 Apr;50(4):803-9.PMID: 11289045 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB.

Cell. 2001 Jun 15;105(6):745-55.PMID: 11440717 [PubMed - indexed for MEDLINE]Related articles