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    Results: 1 to 20 of 379

    1.

    Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets.

    Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY.

    Diabetes. 2006 Oct;55(10):2713-22.PMID: 17003335 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication.

    Maedler K, Fontana A, Ris F, Sergeev P, Toso C, Oberholzer J, Lehmann R, Bachmann F, Tasinato A, Spinas GA, Halban PA, Donath MY.

    Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8236-41.PMID: 12060768 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1.

    Maedler K, Schumann DM, Schulthess F, Oberholzer J, Bosco D, Berney T, Donath MY.

    Diabetes. 2006 Sep;55(9):2455-62.PMID: 16936193 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.

    Maedler K, Sergeev P, Ehses JA, Mathe Z, Bosco D, Berney T, Dayer JM, Reinecke M, Halban PA, Donath MY.

    Proc Natl Acad Sci U S A. 2004 May 25;101(21):8138-43. Epub 2004 May 12.PMID: 15141093 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

    Welsh N, Cnop M, Kharroubi I, Bugliani M, Lupi R, Marchetti P, Eizirik DL.

    Diabetes. 2005 Nov;54(11):3238-44.PMID: 16249450 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro.

    Giannoukakis N, Rudert WA, Ghivizzani SC, Gambotto A, Ricordi C, Trucco M, Robbins PD.

    Diabetes. 1999 Sep;48(9):1730-6.PMID: 10480601 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.

    Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY.

    J Clin Invest. 2002 Sep;110(6):851-60.PMID: 12235117 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1.

    Brun T, He KH, Lupi R, Boehm B, Wojtusciszyn A, Sauter N, Donath M, Marchetti P, Maedler K, Gauthier BR.

    Hum Mol Genet. 2008 Feb 15;17(4):478-89. Epub 2007 Nov 7.PMID: 17989064 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    A role for caspase-8 and c-FLIPL in proliferation and cell-cycle progression of primary hepatocytes.

    Gilot D, Serandour AL, Ilyin GP, Lagadic-Gossmann D, Loyer P, Corlu A, Coutant A, Baffet G, Peter ME, Fardel O, Guguen-Guillouzo C.

    Carcinogenesis. 2005 Dec;26(12):2086-94. Epub 2005 Jul 20.PMID: 16033771 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Adenoviral overexpression of interleukin-1 receptor antagonist protein increases beta-cell replication in rat pancreatic islets.

    Téllez N, Montolio M, Biarnés M, Castaño E, Soler J, Montanya E.

    Gene Ther. 2005 Jan;12(2):120-8.PMID: 15578044 [PubMed - indexed for MEDLINE]Related articles

    11.

    The Fas pathway is involved in pancreatic beta cell secretory function.

    Schumann DM, Maedler K, Franklin I, Konrad D, Størling J, Böni-Schnetzler M, Gjinovci A, Kurrer MO, Gauthier BR, Bosco D, Andres A, Berney T, Greter M, Becher B, Chervonsky AV, Halban PA, Mandrup-Poulsen T, Wollheim CB, Donath MY.

    Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2861-6. Epub 2007 Feb 13.PMID: 17299038 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

    Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY.

    Diabetes. 2004 Jul;53(7):1706-13.PMID: 15220194 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells.

    Rütti S, Ehses JA, Sibler RA, Prazak R, Rohrer L, Georgopoulos S, Meier DT, Niclauss N, Berney T, Donath MY, von Eckardstein A.

    Endocrinology. 2009 Oct;150(10):4521-30. Epub 2009 Jul 23.PMID: 19628574 [PubMed - indexed for MEDLINE]Related articles

    14.

    Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function.

    Granata R, Settanni F, Gallo D, Trovato L, Biancone L, Cantaluppi V, Nano R, Annunziata M, Campiglia P, Arnoletti E, Ghè C, Volante M, Papotti M, Muccioli G, Ghigo E.

    Diabetes. 2008 Apr;57(4):967-79. Epub 2007 Dec 27.PMID: 18162507 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Requirements of calcium fluxes and ERK kinase activation for glucose- and interleukin-1beta-induced beta-cell apoptosis.

    Fei H, Zhao B, Zhao S, Wang Q.

    Mol Cell Biochem. 2008 Aug;315(1-2):75-84. Epub 2008 May 23.PMID: 18498041 [PubMed - indexed for MEDLINE]Related articles

    16.

    Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases.

    Maedler K, Schulthess FT, Bielman C, Berney T, Bonny C, Prentki M, Donath MY, Roduit R.

    FASEB J. 2008 Jun;22(6):1905-13. Epub 2008 Feb 8.PMID: 18263705 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia.

    Sauter NS, Schulthess FT, Galasso R, Castellani LW, Maedler K.

    Endocrinology. 2008 May;149(5):2208-18. Epub 2008 Jan 31.PMID: 18239070 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.

    Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G.

    Endocrinology. 2007 Feb;148(2):512-29. Epub 2006 Oct 26.PMID: 17068144 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    A biphasic role of nuclear transcription factor (NF)-kappaB in the islet beta-cell apoptosis induced by interleukin (IL)-1beta.

    Papaccio G, Graziano A, D'Aquino R, Valiante S, Naro F.

    J Cell Physiol. 2005 Jul;204(1):124-30.PMID: 15622524 [PubMed - indexed for MEDLINE]Related articles

    20.

    Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I.

    Giannoukakis N, Mi Z, Rudert WA, Gambotto A, Trucco M, Robbins P.

    Gene Ther. 2000 Dec;7(23):2015-22.PMID: 11175313 [PubMed - indexed for MEDLINE]Related articlesFree article

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