PubMed

Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice.

Gray SL, Nora ED, Grosse J, Manieri M, Stoeger T, Medina-Gomez G, Burling K, Wattler S, Russ A, Yeo GS, Chatterjee VK, O'Rahilly S, Voshol PJ, Cinti S, Vidal-Puig A.

Diabetes. 2006 Oct;55(10):2669-77.PMID: 17003330 [PubMed - indexed for MEDLINE]Related articlesFree article

Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice.

Verreth W, De Keyzer D, Pelat M, Verhamme P, Ganame J, Bielicki JK, Mertens A, Quarck R, Benhabilès N, Marguerie G, Mackness B, Mackness M, Ninio E, Herregods MC, Balligand JL, Holvoet P.

Circulation. 2004 Nov 16;110(20):3259-69. Epub 2004 Nov 8.PMID: 15533870 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased brown adipocyte recruitment and thermogenic capacity in mice with impaired peroxisome proliferator-activated receptor (P465L PPARgamma) function.

Gray SL, Dalla Nora E, Backlund EC, Manieri M, Virtue S, Noland RC, O'Rahilly S, Cortright RN, Cinti S, Cannon B, Vidal-Puig A.

Endocrinology. 2006 Dec;147(12):5708-14. Epub 2006 Sep 15.PMID: 16980437 [PubMed - indexed for MEDLINE]Related articlesFree article

The effects of obesity-associated insulin resistance on mRNA expression of peroxisome proliferator-activated receptor-gamma target genes, in dogs.

Gayet C, Leray V, Saito M, Siliart B, Nguyen P.

Br J Nutr. 2007 Sep;98(3):497-503. Epub 2007 May 3.PMID: 17475082 [PubMed - indexed for MEDLINE]Related articles

Impact of increased PPARgamma activity in adipocytes in vivo on adiposity, insulin sensitivity and the effects of rosiglitazone treatment.

Takasawa K, Kubota N, Terauchi Y, Kadowaki T.

Endocr J. 2008 Aug;55(4):767-76. Epub 2008 May 28.PMID: 18506083 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma.

Tsai YS, Kim HJ, Takahashi N, Kim HS, Hagaman JR, Kim JK, Maeda N.

J Clin Invest. 2004 Jul;114(2):240-9.PMID: 15254591 [PubMed - indexed for MEDLINE]Related articlesFree article

PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.

Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A.

PLoS Genet. 2007 Apr 27;3(4):e64.PMID: 17465682 [PubMed - indexed for MEDLINE]Related articlesFree article

Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance.

Jones JR, Barrick C, Kim KA, Lindner J, Blondeau B, Fujimoto Y, Shiota M, Kesterson RA, Kahn BB, Magnuson MA.

Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6207-12. Epub 2005 Apr 15.PMID: 15833818 [PubMed - indexed for MEDLINE]Related articlesFree article

PPARgamma-mediated insulin sensitization: the importance of fat versus muscle.

Kintscher U, Law RE.

Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E287-91. Review.PMID: 15637349 [PubMed - indexed for MEDLINE]Related articlesFree article

Review: Peroxisome proliferator-activated receptor gamma and adipose tissue--understanding obesity-related changes in regulation of lipid and glucose metabolism.

Sharma AM, Staels B.

J Clin Endocrinol Metab. 2007 Feb;92(2):386-95. Epub 2006 Dec 5. Review.PMID: 17148564 [PubMed - indexed for MEDLINE]Related articlesFree article

The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform.

Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppänen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A.

Diabetes. 2005 Jun;54(6):1706-16.PMID: 15919792 [PubMed - indexed for MEDLINE]Related articlesFree article

Nuclear receptors as targets for drug development: molecular mechanisms for regulation of obesity and insulin resistance by peroxisome proliferator-activated receptor gamma, CREB-binding protein, and adiponectin.

Tsuchida A, Yamauchi T, Kadowaki T.

J Pharmacol Sci. 2005 Feb;97(2):164-70. Epub 2005 Feb 11. Review.PMID: 15725703 [PubMed - indexed for MEDLINE]Related articlesFree article

Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet.

Matsui J, Terauchi Y, Kubota N, Takamoto I, Eto K, Yamashita T, Komeda K, Yamauchi T, Kamon J, Kita S, Noda M, Kadowaki T.

Diabetes. 2004 Nov;53(11):2844-54.PMID: 15504964 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipogenesis and lipotoxicity: role of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgammacoactivator-1 (PGC1).

Medina-Gomez G, Gray S, Vidal-Puig A.

Public Health Nutr. 2007 Oct;10(10A):1132-7. Review.PMID: 17903321 [PubMed - indexed for MEDLINE]Related articles

PPARgamma: a critical determinant of body fat distribution in humans and mice.

Tsai YS, Maeda N.

Trends Cardiovasc Med. 2005 Apr;15(3):81-5. Review.PMID: 16039966 [PubMed - indexed for MEDLINE]Related articles

Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states.

Muise ES, Azzolina B, Kuo DW, El-Sherbeini M, Tan Y, Yuan X, Mu J, Thompson JR, Berger JP, Wong KK.

Mol Pharmacol. 2008 Aug;74(2):403-12. Epub 2008 May 8.PMID: 18467542 [PubMed - indexed for MEDLINE]Related articlesFree article

A dominant negative peroxisome proliferator-activated receptor-gamma knock-in mouse exhibits features of the metabolic syndrome.

Freedman BD, Lee EJ, Park Y, Jameson JL.

J Biol Chem. 2005 Apr 29;280(17):17118-25. Epub 2005 Feb 15.PMID: 15716267 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor gamma and the regulation of adipocyte function: lessons from human genetic studies.

Gurnell M.

Best Pract Res Clin Endocrinol Metab. 2005 Dec;19(4):501-23. Review.PMID: 16311214 [PubMed - indexed for MEDLINE]Related articles

Mouse models of PPAR-gamma deficiency: dissecting PPAR-gamma's role in metabolic homoeostasis.

Gray SL, Dalla Nora E, Vidal-Puig AJ.

Biochem Soc Trans. 2005 Nov;33(Pt 5):1053-8. Review.PMID: 16246044 [PubMed - indexed for MEDLINE]Related articles

Adipose tissue gene expression profiles in ob/ob mice treated with leptin.

Zhang W, Della-Fera MA, Hartzell DL, Hausman D, Baile CA.

Life Sci. 2008 Jul 4;83(1-2):35-42. Epub 2008 May 10.PMID: 18547592 [PubMed - indexed for MEDLINE]Related articles