PubMed

New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals.

Bochenski J, Placha G, Wanic K, Malecki M, Sieradzki J, Warram JH, Krolewski AS.

Diabetes. 2006 Sep;55(9):2626-30.PMID: 16936213 [PubMed - indexed for MEDLINE]Related articlesFree article

ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study.

Meyre D, Bouatia-Naji N, Vatin V, Veslot J, Samson C, Tichet J, Marre M, Balkau B, Froguel P.

Diabetologia. 2007 Oct;50(10):2090-6. Epub 2007 Aug 18.PMID: 17704904 [PubMed - indexed for MEDLINE]Related articles

Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population.

El Achhab Y, Meyre D, Bouatia-Naji N, Berraho M, Deweirder M, Vatin V, Delplanque J, Serhier Z, Lyoussi B, Nejjari C, Froguel P, Chikri M.

Diabetes Metab. 2009 Feb;35(1):37-42. Epub 2008 Nov 28.PMID: 19046915 [PubMed - indexed for MEDLINE]Related articles

Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity.

Lyon HN, Florez JC, Bersaglieri T, Saxena R, Winckler W, Almgren P, Lindblad U, Tuomi T, Gaudet D, Zhu X, Cooper R, Ardlie KG, Daly MJ, Altshuler D, Groop L, Hirschhorn JN.

Diabetes. 2006 Nov;55(11):3180-4.PMID: 17065359 [PubMed - indexed for MEDLINE]Related articlesFree article

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.

Stolerman ES, Manning AK, McAteer JB, Dupuis J, Fox CS, Cupples LA, Meigs JB, Florez JC.

Diabetes. 2008 Jul;57(7):1971-7. Epub 2008 Apr 21.PMID: 18426862 [PubMed - indexed for MEDLINE]Related articlesFree article

Further evidence for the role of ENPP1 in obesity: association with morbid obesity in Finns.

Valli-Jaakola K, Suviolahti E, Schalin-Jäntti C, Ripatti S, Silander K, Oksanen L, Salomaa V, Peltonen L, Kontula K.

Obesity (Silver Spring). 2008 Sep;16(9):2113-9.PMID: 18551113 [PubMed - indexed for MEDLINE]Related articles

Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.

Grarup N, Urhammer SA, Ek J, Albrechtsen A, Glümer C, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O.

Diabetologia. 2006 Sep;49(9):2097-104. Epub 2006 Jul 25.PMID: 16865358 [PubMed - indexed for MEDLINE]Related articles

Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population.

Tanyolaç S, Mahley RW, Hodoglugil U, Goldfine ID.

Obesity (Silver Spring). 2008 Nov;16(11):2468-71. Epub 2008 Aug 21.PMID: 18719658 [PubMed - indexed for MEDLINE]Related articles

Effect of the rs997509 polymorphism on the association between ectonucleotide pyrophosphatase phosphodiesterase 1 and metabolic syndrome and impaired glucose tolerance in childhood obesity.

Santoro N, Cirillo G, Lepore MG, Palma A, Amato A, Savarese P, Marzuillo P, Grandone A, Perrone L, Del Giudice EM.

J Clin Endocrinol Metab. 2009 Jan;94(1):300-5. Epub 2008 Oct 21.PMID: 18940878 [PubMed - indexed for MEDLINE]Related articles

No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.

Weedon MN, Shields B, Hitman G, Walker M, McCarthy MI, Hattersley AT, Frayling TM.

Diabetes. 2006 Nov;55(11):3175-9.PMID: 17065358 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of genetic variation in ENPP1 with obesity-related phenotypes.

Jenkinson CP, Coletta DK, Flechtner-Mors M, Hu SL, Fourcaudot MJ, Rodriguez LM, Schneider J, Arya R, Stern MP, Blangero J, Duggirala R, DeFronzo RA.

Obesity (Silver Spring). 2008 Jul;16(7):1708-13. Epub 2008 May 8.PMID: 18464750 [PubMed - indexed for MEDLINE]Related articles

The K121Q polymorphism in ENPP1 (PC-1) is not associated with type 2 diabetes or obesity in Korean male workers.

Seo HJ, Kim SG, Kwon OJ.

J Korean Med Sci. 2008 Jun;23(3):459-64.PMID: 18583883 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of ENPP1 (PC-1) K121Q polymorphism with obesity-related parameters in subjects with metabolic syndrome.

González-Sánchez JL, Zabena C, Martínez-Larrad MT, Martínez-Calatrava MJ, Pérez-Barba M, Serrano-Ríos M.

Clin Endocrinol (Oxf). 2008 May;68(5):724-9. Epub 2007 Nov 6.PMID: 17986276 [PubMed - indexed for MEDLINE]Related articles

The K121Q polymorphism of ENPP1 and peripheral arterial disease.

Eller P, Schgoer W, Mueller T, Tancevski I, Demetz E, Duwensee K, Ritsch A, Haltmayer M, Patsch JR.

Heart Vessels. 2008 Mar;23(2):104-7. Epub 2008 Apr 4.PMID: 18389334 [PubMed - indexed for MEDLINE]Related articles

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.

Meyre D, Bouatia-Naji N, Tounian A, Samson C, Lecoeur C, Vatin V, Ghoussaini M, Wachter C, Hercberg S, Charpentier G, Patsch W, Pattou F, Charles MA, Tounian P, Clément K, Jouret B, Weill J, Maddux BA, Goldfine ID, Walley A, Boutin P, Dina C, Froguel P.

Nat Genet. 2005 Aug;37(8):863-7. Epub 2005 Jul 17.PMID: 16025115 [PubMed - indexed for MEDLINE]Related articlesFree article

The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction.

Bacci S, Ludovico O, Prudente S, Zhang YY, Di Paola R, Mangiacotti D, Rauseo A, Nolan D, Duffy J, Fini G, Salvemini L, Amico C, Vigna C, Pellegrini F, Menzaghi C, Doria A, Trischitta V.

Diabetes. 2005 Oct;54(10):3021-5.PMID: 16186408 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy.

Keene KL, Mychaleckyj JC, Smith SG, Leak TS, Perlegas PS, Langefeld CD, Freedman BI, Rich SS, Bowden DW, Sale MM.

Diabetes. 2008 Apr;57(4):1057-62. Epub 2008 Jan 9.PMID: 18184924 [PubMed - indexed for MEDLINE]Related articlesFree article

The Q121 variant of ENPP1 may protect from childhood overweight/obesity in the Italian population.

Morandi A, Pinelli L, Petrone A, Vatin V, Buzzetti R, Froguel P, Meyre D.

Obesity (Silver Spring). 2009 Jan;17(1):202-6. Epub 2008 Oct 23.PMID: 18948963 [PubMed - indexed for MEDLINE]Related articles

PC-1 (ENPP1) K121Q polymorphism in overweight and obese type 2 diabetic coronary heart disease patients.

Lazarevic G, Milojkovic M, Tasic I, Najman S, Antic S, Stefanovic V.

Acta Cardiol. 2008 Jun;63(3):323-30.PMID: 18664022 [PubMed - indexed for MEDLINE]Related articles

ENPP1 variants and haplotypes predispose to early onset obesity and impaired glucose and insulin metabolism in German obese children.

Böttcher Y, Körner A, Reinehr T, Enigk B, Kiess W, Stumvoll M, Kovacs P.

J Clin Endocrinol Metab. 2006 Dec;91(12):4948-52. Epub 2006 Sep 12.PMID: 16968801 [PubMed - indexed for MEDLINE]Related articlesFree article