PubMed

Halofenate is a selective peroxisome proliferator-activated receptor gamma modulator with antidiabetic activity.

Allen T, Zhang F, Moodie SA, Clemens LE, Smith A, Gregoire F, Bell A, Muscat GE, Gustafson TA.

Diabetes. 2006 Sep;55(9):2523-33.PMID: 16936200 [PubMed - indexed for MEDLINE]Related articlesFree article

MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema.

Gregoire FM, Zhang F, Clarke HJ, Gustafson TA, Sears DD, Favelyukis S, Lenhard J, Rentzeperis D, Clemens LE, Mu Y, Lavan BE.

Mol Endocrinol. 2009 Jul;23(7):975-88. Epub 2009 Apr 23.PMID: 19389808 [PubMed - indexed for MEDLINE]Related articles

A novel selective peroxisome proliferator-activator receptor-gamma modulator-SPPARgammaM5 improves insulin sensitivity with diminished adverse cardiovascular effects.

Chang CH, McNamara LA, Wu MS, Muise ES, Tan Y, Wood HB, Meinke PT, Thompson JR, Doebber TW, Berger JP, McCann ME.

Eur J Pharmacol. 2008 Apr 14;584(1):192-201. Epub 2008 Feb 14.PMID: 18346728 [PubMed - indexed for MEDLINE]Related articles

INT131: a selective modulator of PPAR gamma.

Motani A, Wang Z, Weiszmann J, McGee LR, Lee G, Liu Q, Staunton J, Fang Z, Fuentes H, Lindstrom M, Liu J, Biermann DH, Jaen J, Walker NP, Learned RM, Chen JL, Li Y.

J Mol Biol. 2009 Mar 13;386(5):1301-11.PMID: 19452630 [PubMed - indexed for MEDLINE]Related articles

A peroxisome proliferator-activated receptor alpha/gamma dual agonist with a unique in vitro profile and potent glucose and lipid effects in rodent models of type 2 diabetes and dyslipidemia.

Reifel-Miller A, Otto K, Hawkins E, Barr R, Bensch WR, Bull C, Dana S, Klausing K, Martin JA, Rafaeloff-Phail R, Rafizadeh-Montrose C, Rhodes G, Robey R, Rojo I, Rungta D, Snyder D, Wilbur K, Zhang T, Zink R, Warshawsky A, Brozinick JT.

Mol Endocrinol. 2005 Jun;19(6):1593-605. Epub 2005 Apr 14.PMID: 15831517 [PubMed - indexed for MEDLINE]Related articlesFree article

A selective peroxisome proliferator-activated receptor gamma modulator with distinct fat cell regulation properties.

Fujimura T, Kimura C, Oe T, Takata Y, Sakuma H, Aramori I, Mutoh S.

J Pharmacol Exp Ther. 2006 Aug;318(2):863-71. Epub 2006 May 8.PMID: 16682454 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel genes regulated by the insulin sensitizer rosiglitazone during adipocyte differentiation.

Albrektsen T, Frederiksen KS, Holmes WE, Boel E, Taylor K, Fleckner J.

Diabetes. 2002 Apr;51(4):1042-51.PMID: 11916924 [PubMed - indexed for MEDLINE]Related articlesFree article

The potential insulin sensitizing and glucose lowering effects of a novel indole derivative in vitro and in vivo.

Li YY, Wu HS, Tang L, Feng CR, Yu JH, Li Y, Yang YS, Yang B, He QJ.

Pharmacol Res. 2007 Oct;56(4):335-43. Epub 2007 Aug 9.PMID: 17889553 [PubMed - indexed for MEDLINE]Related articles

T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties.

Li Y, Wang Z, Furukawa N, Escaron P, Weiszmann J, Lee G, Lindstrom M, Liu J, Liu X, Xu H, Plotnikova O, Prasad V, Walker N, Learned RM, Chen JL.

J Biol Chem. 2008 Apr 4;283(14):9168-76. Epub 2008 Feb 7.PMID: 18263587 [PubMed - indexed for MEDLINE]Related articlesFree article

Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism.

Dallaire P, Bellmann K, Laplante M, Gélinas S, Centeno-Baez C, Penfornis P, Peyot ML, Latour MG, Lamontagne J, Trujillo ME, Scherer PE, Prentki M, Deshaies Y, Marette A.

Diabetes. 2008 Aug;57(8):1999-2011. Epub 2008 May 5.PMID: 18458147 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes.

Wang H, Qiang L, Farmer SR.

Mol Cell Biol. 2008 Jan;28(1):188-200. Epub 2007 Oct 22.PMID: 17954559 [PubMed - indexed for MEDLINE]Related articlesFree article

KR-62980: a novel peroxisome proliferator-activated receptor gamma agonist with weak adipogenic effects.

Kim KR, Lee JH, Kim SJ, Rhee SD, Jung WH, Yang SD, Kim SS, Ahn JH, Cheon HG.

Biochem Pharmacol. 2006 Aug 14;72(4):446-54. Epub 2006 May 12.PMID: 16797489 [PubMed - indexed for MEDLINE]Related articles

Pharmacological profile of a novel, non-TZD PPARgamma agonist.

Chen X, Osborne MC, Rybczynski PJ, Zeck R, Yang M, Xu J, Zhou L, Cryan E, Tang Y, Demarest KT.

Diabetes Obes Metab. 2005 Sep;7(5):536-46.PMID: 16050946 [PubMed - indexed for MEDLINE]Related articles

A novel peroxisome proliferator-activated gamma (PPAR gamma) agonist, CLX-0921, has potent antihyperglycemic activity with low adipogenic potential.

Dey D, Medicherla S, Neogi P, Gowri M, Cheng J, Gross C, Sharma SD, Reaven GM, Nag B.

Metabolism. 2003 Aug;52(8):1012-8.PMID: 12898466 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone modulates insulin-induced plasma membrane area changes in single 3T3-L1 adipocytes.

Velebit J, Kovacic PB, Prebil M, Chowdhury HH, Grilc S, Kreft M, Jensen J, Isenović ER, Zorec R.

J Membr Biol. 2008 Jun;223(3):141-9. Epub 2008 Aug 27.PMID: 18754069 [PubMed - indexed for MEDLINE]Related articles

Identification of a novel agonist of peroxisome proliferator-activated receptors alpha and gamma that may contribute to the anti-diabetic activity of guggulipid in Lep(ob)/Lep(ob) mice.

Cornick CL, Strongitharm BH, Sassano G, Rawlins C, Mayes AE, Joseph AN, O'Dowd J, Stocker C, Wargent E, Cawthorne MA, Brown AL, Arch JR.

J Nutr Biochem. 2009 Oct;20(10):806-15. Epub 2008 Oct 15.PMID: 18926687 [PubMed - indexed for MEDLINE]Related articles

Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone.

Camp HS, Li O, Wise SC, Hong YH, Frankowski CL, Shen X, Vanbogelen R, Leff T.

Diabetes. 2000 Apr;49(4):539-47.PMID: 10871190 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoglycemic action of thiazolidinediones/peroxisome proliferator-activated receptor gamma by inhibition of the c-Jun NH2-terminal kinase pathway.

Díaz-Delfín J, Morales M, Caelles C.

Diabetes. 2007 Jul;56(7):1865-71. Epub 2007 Apr 6.PMID: 17416798 [PubMed - indexed for MEDLINE]Related articlesFree article

Antidiabetic and adipogenic properties in a newly synthesized thiazolidine derivative, FPFS-410.

Norisada N, Masuzaki H, Fujimoto M, Inoue G, Hosoda K, Hayashi T, Watanabe M, Muraoka S, Yoneda F, Nakao K.

Metabolism. 2004 Dec;53(12):1532-7. Erratum in: Metabolism. 2005 Dec;54(12):1694. PMID: 15562395 [PubMed - indexed for MEDLINE]Related articles

Antidiabetic and hypolipidemic potential of DRF 2519--a dual activator of PPAR-alpha and PPAR-gamma.

Chakrabarti R, Misra P, Vikramadithyan RK, Premkumar M, Hiriyan J, Datla SR, Damarla RK, Suresh J, Rajagopalan R.

Eur J Pharmacol. 2004 May 3;491(2-3):195-206.PMID: 15140637 [PubMed - indexed for MEDLINE]Related articles