PubMed

Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes.

Proctor G, Jiang T, Iwahashi M, Wang Z, Li J, Levi M.

Diabetes. 2006 Sep;55(9):2502-9.PMID: 16936198 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes.

Wang Z, Jiang T, Li J, Proctor G, McManaman JL, Lucia S, Chua S, Levi M.

Diabetes. 2005 Aug;54(8):2328-35.PMID: 16046298 [PubMed - indexed for MEDLINE]Related articlesFree article

Farnesoid X receptor modulates renal lipid metabolism, fibrosis, and diabetic nephropathy.

Jiang T, Wang XX, Scherzer P, Wilson P, Tallman J, Takahashi H, Li J, Iwahashi M, Sutherland E, Arend L, Levi M.

Diabetes. 2007 Oct;56(10):2485-93. Epub 2007 Jul 27.PMID: 17660268 [PubMed - indexed for MEDLINE]Related articlesFree article

The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR.

Cha JY, Repa JJ.

J Biol Chem. 2007 Jan 5;282(1):743-51. Epub 2006 Nov 14.PMID: 17107947 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal disease.

Jiang T, Liebman SE, Lucia MS, Li J, Levi M.

Kidney Int. 2005 Dec;68(6):2608-20.PMID: 16316337 [PubMed - indexed for MEDLINE]Related articles

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.

Yoshikawa T, Ide T, Shimano H, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Yatoh S, Kitamine T, Okazaki H, Tamura Y, Sekiya M, Takahashi A, Hasty AH, Sato R, Sone H, Osuga J, Ishibashi S, Yamada N.

Mol Endocrinol. 2003 Jul;17(7):1240-54. Epub 2003 May 1.PMID: 12730331 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of sterol regulatory element-binding protein 1 in regulation of renal lipid metabolism and glomerulosclerosis in diabetes mellitus.

Sun L, Halaihel N, Zhang W, Rogers T, Levi M.

J Biol Chem. 2002 May 24;277(21):18919-27. Epub 2002 Mar 1.PMID: 11875060 [PubMed - indexed for MEDLINE]Related articlesFree article

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.

Ide T, Shimano H, Yoshikawa T, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Nakakuki M, Yatoh S, Iizuka Y, Tomita S, Ohashi K, Takahashi A, Sone H, Gotoda T, Osuga J, Ishibashi S, Yamada N.

Mol Endocrinol. 2003 Jul;17(7):1255-67. Epub 2003 May 1.PMID: 12730332 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.

Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ.

Genes Dev. 2000 Nov 15;14(22):2819-30.PMID: 11090130 [PubMed - indexed for MEDLINE]Related articlesFree article

Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway.

Jiang T, Wang Z, Proctor G, Moskowitz S, Liebman SE, Rogers T, Lucia MS, Li J, Levi M.

J Biol Chem. 2005 Sep 16;280(37):32317-25. Epub 2005 Jul 25.PMID: 16046411 [PubMed - indexed for MEDLINE]Related articlesFree article

Downregulation of liver X receptor-alpha in mouse kidney and HK-2 proximal tubular cells by LPS and cytokines.

Wang Y, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR.

J Lipid Res. 2005 Nov;46(11):2377-87. Epub 2005 Aug 16.PMID: 16106051 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting.

Quinet EM, Savio DA, Halpern AR, Chen L, Schuster GU, Gustafsson JA, Basso MD, Nambi P.

Mol Pharmacol. 2006 Oct;70(4):1340-9. Epub 2006 Jul 6.PMID: 16825483 [PubMed - indexed for MEDLINE]Related articlesFree article

Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-deficient mice.

Patel DD, Knight BL, Wiggins D, Humphreys SM, Gibbons GF.

J Lipid Res. 2001 Mar;42(3):328-37.PMID: 11254743 [PubMed - indexed for MEDLINE]Related articlesFree article

Calorie restriction modulates renal expression of sterol regulatory element binding proteins, lipid accumulation, and age-related renal disease.

Jiang T, Liebman SE, Lucia MS, Phillips CL, Levi M.

J Am Soc Nephrol. 2005 Aug;16(8):2385-94. Epub 2005 Jun 8.PMID: 15944339 [PubMed - indexed for MEDLINE]Related articlesFree article

Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport.

Field FJ, Born E, Murthy S, Mathur SN.

Biochem J. 2002 Dec 15;368(Pt 3):855-64.PMID: 12213084 [PubMed - indexed for MEDLINE]Related articlesFree article

SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR.

Wong J, Quinn CM, Brown AJ.

Biochem J. 2006 Dec 15;400(3):485-91.PMID: 16901265 [PubMed - indexed for MEDLINE]Related articlesFree article

Coadministration of a liver X receptor agonist and a peroxisome proliferator activator receptor-alpha agonist in Mice: effects of nuclear receptor interplay on high-density lipoprotein and triglyceride metabolism in vivo.

Beyer TP, Schmidt RJ, Foxworthy P, Zhang Y, Dai J, Bensch WR, Kauffman RF, Gao H, Ryan TP, Jiang XC, Karathanasis SK, Eacho PI, Cao G.

J Pharmacol Exp Ther. 2004 Jun;309(3):861-8. Epub 2004 Feb 11.PMID: 14960661 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice.

Ma KL, Ruan XZ, Powis SH, Chen Y, Moorhead JF, Varghese Z.

Hepatology. 2008 Sep;48(3):770-81.PMID: 18752326 [PubMed - indexed for MEDLINE]Related articles

Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status.

Tamehiro N, Shigemoto-Mogami Y, Kakeya T, Okuhira K, Suzuki K, Sato R, Nagao T, Nishimaki-Mogami T.

J Biol Chem. 2007 Jul 20;282(29):21090-9. Epub 2007 May 27.PMID: 17526932 [PubMed - indexed for MEDLINE]Related articlesFree article

Interrelationship between liver X receptor alpha, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma, and small heterodimer partner in the transcriptional regulation of glucokinase gene expression in liver.

Kim TH, Kim H, Park JM, Im SS, Bae JS, Kim MY, Yoon HG, Cha JY, Kim KS, Ahn YH.

J Biol Chem. 2009 May 29;284(22):15071-83. Epub 2009 Apr 14.PMID: 19366697 [PubMed - indexed for MEDLINE]Related articles