PubMed

Glucose toxicity is responsible for the development of impaired regulation of endogenous glucose production and hepatic glucokinase in Zucker diabetic fatty rats.

Fujimoto Y, Torres TP, Donahue EP, Shiota M.

Diabetes. 2006 Sep;55(9):2479-90.PMID: 16936196 [PubMed - indexed for MEDLINE]Related articlesFree article

A defect in glucose-induced dissociation of glucokinase from the regulatory protein in Zucker diabetic fatty rats in the early stage of diabetes.

Shin JS, Torres TP, Catlin RL, Donahue EP, Shiota M.

Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1381-90. Epub 2007 Jan 4.PMID: 17204595 [PubMed - indexed for MEDLINE]Related articles

Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats.

Torres TP, Catlin RL, Chan R, Fujimoto Y, Sasaki N, Printz RL, Newgard CB, Shiota M.

Diabetes. 2009 Jan;58(1):78-86. Epub 2008 Oct 24.PMID: 18952838 [PubMed - indexed for MEDLINE]Related articlesFree article

Defect in glucokinase translocation in Zucker diabetic fatty rats.

Fujimoto Y, Donahue EP, Shiota M.

Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23. Epub 2004 May 11.PMID: 15138155 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding.

Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen EW.

Diabetes. 1997 Nov;46(11):1768-74.PMID: 9356024 [PubMed - indexed for MEDLINE]Related articles

Hyperglycemia contributes insulin resistance in hepatic and adipose tissue but not skeletal muscle of ZDF rats.

Nawano M, Oku A, Ueta K, Umebayashi I, Ishirahara T, Arakawa K, Saito A, Anai M, Kikuchi M, Asano T.

Am J Physiol Endocrinol Metab. 2000 Mar;278(3):E535-43.PMID: 10710509 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites.

Lam TK, van de Werve G, Giacca A.

Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E281-90.PMID: 12531742 [PubMed - indexed for MEDLINE]Related articlesFree article

For the ZDF rat, "Breaking up is hard to do": dissociation of the GK:GKRP complex.

Lange AJ.

Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1379-80. Epub 2006 Dec 21. No abstract available. PMID: 17185403 [PubMed - indexed for MEDLINE]Related articles

Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production.

Barzilai N, Hawkins M, Angelov I, Hu M, Rossetti L.

Diabetes. 1996 Oct;45(10):1329-35.PMID: 8826967 [PubMed - indexed for MEDLINE]Related articles

Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes.

Rossetti L, Giaccari A, Barzilai N, Howard K, Sebel G, Hu M.

J Clin Invest. 1993 Sep;92(3):1126-34.PMID: 8397219 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase gene transfer to skeletal muscle of diabetic Zucker fatty rats improves insulin-sensitive glucose uptake.

Jiménez-Chillarón JC, Telemaque-Potts S, Gómez-Valadés AG, Anderson P, Newgard CB, Gómez-Foix AM.

Metabolism. 2002 Jan;51(1):121-6.PMID: 11782883 [PubMed - indexed for MEDLINE]Related articles

Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus.

Mevorach M, Giacca A, Aharon Y, Hawkins M, Shamoon H, Rossetti L.

J Clin Invest. 1998 Aug 15;102(4):744-53.PMID: 9710443 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase overexpression restores glucose utilization and storage in cultured hepatocytes from male Zucker diabetic fatty rats.

Seoane J, Barberà A, Télémaque-Potts S, Newgard CB, Guinovart JJ.

J Biol Chem. 1999 Nov 5;274(45):31833-8.PMID: 10542207 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic suppression of insulin by diazoxide alters the activities of key enzymes regulating hepatic gluconeogenesis in Zucker rats.

Alemzadeh R, Holshouser S, Massey P, Koontz J.

Eur J Endocrinol. 2002 Jun;146(6):871-9.PMID: 12039709 [PubMed - indexed for MEDLINE]Related articlesFree article

Relative contribution of glycogenolysis and gluconeogenesis to hepatic glucose production in control and diabetic rats. A re-examination in the presence of euglycaemia.

Giaccari A, Morviducci L, Pastore L, Zorretta D, Sbraccia P, Maroccia E, Buongiorno A, Tamburrano G.

Diabetologia. 1998 Mar;41(3):307-14.PMID: 9541171 [PubMed - indexed for MEDLINE]Related articles

An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism.

Futamura M, Hosaka H, Kadotani A, Shimazaki H, Sasaki K, Ohyama S, Nishimura T, Eiki J, Nagata Y.

J Biol Chem. 2006 Dec 8;281(49):37668-74. Epub 2006 Oct 6.PMID: 17028192 [PubMed - indexed for MEDLINE]Related articlesFree article

Excessive glucose production, rather than insulin resistance, accounts for hyperglycaemia in recent-onset streptozotocin-diabetic rats.

Burcelin R, Eddouks M, Maury J, Kande J, Assan R, Girard J.

Diabetologia. 1995 Mar;38(3):283-90.PMID: 7758874 [PubMed - indexed for MEDLINE]Related articles

The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte.

de la Iglesia N, Mukhtar M, Seoane J, Guinovart JJ, Agius L.

J Biol Chem. 2000 Apr 7;275(14):10597-603.PMID: 10744755 [PubMed - indexed for MEDLINE]Related articlesFree article

Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation.

Farrelly D, Brown KS, Tieman A, Ren J, Lira SA, Hagan D, Gregg R, Mookhtiar KA, Hariharan N.

Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14511-6.PMID: 10588736 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes.

Clore JN, Stillman J, Sugerman H.

Diabetes. 2000 Jun;49(6):969-74.PMID: 10866049 [PubMed - indexed for MEDLINE]Related articlesFree article