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    Results: 1 to 20 of 407

    1.

    Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1.

    Maedler K, Schumann DM, Schulthess F, Oberholzer J, Bosco D, Berney T, Donath MY.

    Diabetes. 2006 Sep;55(9):2455-62.PMID: 16936193 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets.

    Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY.

    Diabetes. 2006 Oct;55(10):2713-22.PMID: 17003335 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication.

    Maedler K, Fontana A, Ris F, Sergeev P, Toso C, Oberholzer J, Lehmann R, Bachmann F, Tasinato A, Spinas GA, Halban PA, Donath MY.

    Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8236-41.PMID: 12060768 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets.

    Maedler K, Spinas GA, Lehmann R, Sergeev P, Weber M, Fontana A, Kaiser N, Donath MY.

    Diabetes. 2001 Aug;50(8):1683-90.PMID: 11473025 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    [Morphological and functional characteristics of pancreatic islet beta cells in natural aging SD rats]

    Wang S, Li J, Li XJ.

    Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Mar;39(2):197-201. Chinese. PMID: 18630682 [PubMed - indexed for MEDLINE]Related articles

    6.

    Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

    Donath MY, Gross DJ, Cerasi E, Kaiser N.

    Diabetes. 1999 Apr;48(4):738-44.PMID: 10102689 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function.

    Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY.

    Diabetes. 2001 Jan;50(1):69-76.PMID: 11147797 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Impaired islet turnover in human donor pancreata with aging.

    Reers C, Erbel S, Esposito I, Schmied B, Büchler MW, Nawroth PP, Ritzel RA.

    Eur J Endocrinol. 2009 Feb;160(2):185-91. Epub 2008 Nov 12.PMID: 19004984 [PubMed - indexed for MEDLINE]Related articles

    9.

    The Fas pathway is involved in pancreatic beta cell secretory function.

    Schumann DM, Maedler K, Franklin I, Konrad D, Størling J, Böni-Schnetzler M, Gjinovci A, Kurrer MO, Gauthier BR, Bosco D, Andres A, Berney T, Greter M, Becher B, Chervonsky AV, Halban PA, Mandrup-Poulsen T, Wollheim CB, Donath MY.

    Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2861-6. Epub 2007 Feb 13.PMID: 17299038 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

    Welsh N, Cnop M, Kharroubi I, Bugliani M, Lupi R, Marchetti P, Eizirik DL.

    Diabetes. 2005 Nov;54(11):3238-44.PMID: 16249450 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Apoptosis in cultured rat islets of langerhans and occurrence of Bcl-2, Bak, Bax, Fas and Fas ligand.

    Hanke J.

    Cells Tissues Organs. 2001;169(2):113-24.PMID: 11399851 [PubMed - indexed for MEDLINE]Related articles

    12.

    Palmitic acid increase levels of pancreatic duodenal homeobox-1 and p38/stress-activated protein kinase in islets from rats maintained on a low protein diet.

    Arantes VC, Reis MA, Latorraca MQ, Ferreira F, Stoppiglia LF, Carneiro EM, Boschero AC.

    Br J Nutr. 2006 Dec;96(6):1006-12.PMID: 17181874 [PubMed - indexed for MEDLINE]Related articles

    13.

    beta-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes.

    Leibowitz G, Yuli M, Donath MY, Nesher R, Melloul D, Cerasi E, Gross DJ, Kaiser N.

    Diabetes. 2001 Feb;50 Suppl 1:S113-7.PMID: 11272167 [PubMed - indexed for MEDLINE]Related articles

    14.

    Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose.

    Marshak S, Leibowitz G, Bertuzzi F, Socci C, Kaiser N, Gross DJ, Cerasi E, Melloul D.

    Diabetes. 1999 Jun;48(6):1230-6.PMID: 10342809 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Exercise improves glucose homeostasis that has been impaired by a high-fat diet by potentiating pancreatic beta-cell function and mass through IRS2 in diabetic rats.

    Park S, Hong SM, Lee JE, Sung SR.

    J Appl Physiol. 2007 Nov;103(5):1764-71. Epub 2007 Aug 30.PMID: 17761790 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

    Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M.

    Diabetologia. 2007 Dec;50(12):2486-94. Epub 2007 Sep 30.PMID: 17906960 [PubMed - indexed for MEDLINE]Related articles

    17.

    Effect of aging on insulin secretory function and expression of beta cell function-related genes of islets.

    Ihm SH, Moon HJ, Kang JG, Park CY, Oh KW, Jeong IK, Oh YS, Park SW.

    Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S150-4. Epub 2007 Apr 30.PMID: 17467845 [PubMed - indexed for MEDLINE]Related articles

    18.

    Surface and intracellular Fas expression associated with cytokine-induced apoptosis in rodent islet and insulinoma cells.

    Augstein P, Wachlin G, Berg S, Bahr J, Salzsieder C, Hehmke B, Heinke P, Salzsieder E.

    J Mol Endocrinol. 2003 Apr;30(2):163-71.PMID: 12683940 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program.

    Federici M, Hribal M, Perego L, Ranalli M, Caradonna Z, Perego C, Usellini L, Nano R, Bonini P, Bertuzzi F, Marlier LN, Davalli AM, Carandente O, Pontiroli AE, Melino G, Marchetti P, Lauro R, Sesti G, Folli F.

    Diabetes. 2001 Jun;50(6):1290-301.PMID: 11375329 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance.

    Nolsøe RL, Hamid YH, Pociot F, Paulsen S, Andersen KM, Borch-Johnsen K, Drivsholm T, Hansen T, Pedersen O, Mandrup-Poulsen T.

    Genes Immun. 2006 Jun;7(4):316-21. Epub 2006 May 4.PMID: 16691186 [PubMed - indexed for MEDLINE]Related articles

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