PubMed

Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways.

Dudek NL, Thomas HE, Mariana L, Sutherland RM, Allison J, Estella E, Angstetra E, Trapani JA, Santamaria P, Lew AM, Kay TW.

Diabetes. 2006 Sep;55(9):2412-8.PMID: 16936188 [PubMed - indexed for MEDLINE]Related articlesFree article

Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL.

McKenzie MD, Dudek NL, Mariana L, Chong MM, Trapani JA, Kay TW, Thomas HE.

Int Immunol. 2006 Jun;18(6):837-46. Epub 2006 Mar 30.PMID: 16574667 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus.

Kreuwel HT, Morgan DJ, Krahl T, Ko A, Sarvetnick N, Sherman LA.

J Immunol. 1999 Oct 15;163(8):4335-41.PMID: 10510373 [PubMed - indexed for MEDLINE]Related articlesFree article

Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice.

Amrani A, Verdaguer J, Anderson B, Utsugi T, Bou S, Santamaria P.

J Clin Invest. 1999 Apr;103(8):1201-9.PMID: 10207172 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction.

Chong MM, Chen Y, Darwiche R, Dudek NL, Irawaty W, Santamaria P, Allison J, Kay TW, Thomas HE.

J Immunol. 2004 May 1;172(9):5714-21.PMID: 15100317 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytes.

Amrani A, Verdaguer J, Thiessen S, Bou S, Santamaria P.

J Clin Invest. 2000 Feb;105(4):459-68.PMID: 10683375 [PubMed - indexed for MEDLINE]Related articlesFree article

SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes.

Barral AM, Thomas HE, Ling EM, Darwiche R, Rodrigo E, Christen U, Ejrnaes M, Wolfe T, Kay TW, von Herrath MG.

J Autoimmun. 2006 Nov;27(3):166-73. Epub 2006 Oct 10.PMID: 17045460 [PubMed - indexed for MEDLINE]Related articles

Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules.

Balasa B, Van Gunst K, Jung N, Balakrishna D, Santamaria P, Hanafusa T, Itoh N, Sarvetnick N.

J Immunol. 2000 Sep 1;165(5):2841-9.PMID: 10946317 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential contribution of Fas- and perforin-mediated mechanisms to the cell-mediated cytotoxic activity of naive and in vivo-primed intestinal intraepithelial lymphocytes.

Corazza N, Müller S, Brunner T, Kägi D, Mueller C.

J Immunol. 2000 Jan 1;164(1):398-403.PMID: 10605035 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet rejection in perforin-deficient mice: the role of perforin and Fas.

Ahmed KR, Guo TB, Gaal KK.

Transplantation. 1997 Apr 15;63(7):951-7.PMID: 9112346 [PubMed - indexed for MEDLINE]Related articles

Xenospecific cytotoxic T lymphocytes: potent lysis in vitro and in vivo.

Smyth MJ, Kershaw MH, Trapani JA.

Transplantation. 1997 Apr 27;63(8):1171-8.PMID: 9133481 [PubMed - indexed for MEDLINE]Related articles

Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice.

Allison J, Thomas HE, Catterall T, Kay TW, Strasser A.

J Immunol. 2005 Jul 1;175(1):293-301.PMID: 15972661 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of Fas-FasL in CD8+ T-cell-mediated insulin-dependent diabetes mellitus (IDDM).

Kreuwel HT, Sherman LA.

J Clin Immunol. 2001 Jan;21(1):15-8. Review.PMID: 11321233 [PubMed - indexed for MEDLINE]Related articles

Absolute requirement of macrophages for the development and activation of beta-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice.

Jun HS, Santamaria P, Lim HW, Zhang ML, Yoon JW.

Diabetes. 1999 Jan;48(1):34-42.PMID: 9892220 [PubMed - indexed for MEDLINE]Related articlesFree article

A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: possible role of membrane TNF.

Herrera PL, Harlan DM, Vassalli P.

Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):279-84.PMID: 10618409 [PubMed - indexed for MEDLINE]Related articlesFree article

Xenospecific cytotoxic T lymphocytes use perforin- and Fas-mediated lytic pathways.

Smyth MJ, Sutton VR, Kershaw MH, Trapani JA.

Transplantation. 1996 Nov 27;62(10):1529-32.PMID: 8958289 [PubMed - indexed for MEDLINE]Related articles

Fas and Fas ligand immunolocalization in pancreatic islets of NOD mice during spontaneous and cyclophosphamide-accelerated diabetes.

Redd S, Ginn S, Ross JM.

Histochem J. 2002 Jan-Feb;34(1-2):1-12.PMID: 12365794 [PubMed - indexed for MEDLINE]Related articles

Bcl-2 protects against Fas-based but not perforin-based T cell-mediated cytolysis.

Lee RK, Spielman J, Podack ER.

Int Immunol. 1996 Jul;8(7):991-1000.PMID: 8757944 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytotoxic T cell mechanisms of beta cell destruction in non-obese diabetic mice.

Kay TW, Dudek NL, Graham K, Estella E, Angstetra E, McKenzie MD, Allison J, Thomas HE.

Novartis Found Symp. 2008;292:68-78; discussion 78-84, 122-9, 202-3.PMID: 19203093 [PubMed - indexed for MEDLINE]Related articles

Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity.

Kataoka T, Shinohara N, Takayama H, Takaku K, Kondo S, Yonehara S, Nagai K.

J Immunol. 1996 May 15;156(10):3678-86.PMID: 8621902 [PubMed - indexed for MEDLINE]Related articles