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Cdc45-MCM-GINS, a new power player for DNA replication.

Aparicio T, Ibarra A, Méndez J.

Cell Div. 2006 Aug 24;1:18.PMID: 16930479 [PubMed]Related articlesFree article

CDK- and Cdc45-dependent priming of the MCM complex on chromatin during S-phase in Xenopus egg extracts: possible activation of MCM helicase by association with Cdc45.

Masuda T, Mimura S, Takisawa H.

Genes Cells. 2003 Feb;8(2):145-61.PMID: 12581157 [PubMed - indexed for MEDLINE]Related articles

Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks.

Kanemaki M, Labib K.

EMBO J. 2006 Apr 19;25(8):1753-63. Epub 2006 Apr 6.PMID: 16601689 [PubMed - indexed for MEDLINE]Related articlesFree article

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase.

Moyer SE, Lewis PW, Botchan MR.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10236-41. Epub 2006 Jun 23.PMID: 16798881 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure and function of the GINS complex, a key component of the eukaryotic replisome.

MacNeill SA.

Biochem J. 2010 Jan 15;425(3):489-500. Review.PMID: 20070258 [PubMed - indexed for MEDLINE]Related articles

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks.

Gambus A, Jones RC, Sanchez-Diaz A, Kanemaki M, van Deursen F, Edmondson RD, Labib K.

Nat Cell Biol. 2006 Apr;8(4):358-66. Epub 2006 Mar 12.PMID: 16531994 [PubMed - indexed for MEDLINE]Related articles

Molecular architecture of the human GINS complex.

Boskovic J, Coloma J, Aparicio T, Zhou M, Robinson CV, Méndez J, Montoya G.

EMBO Rep. 2007 Jul;8(7):678-84. Epub 2007 Jun 8.PMID: 17557111 [PubMed - indexed for MEDLINE]Related articlesFree article

The GINS complex from Pyrococcus furiosus stimulates the MCM helicase activity.

Yoshimochi T, Fujikane R, Kawanami M, Matsunaga F, Ishino Y.

J Biol Chem. 2008 Jan 18;283(3):1601-9. Epub 2007 Nov 5.PMID: 17986447 [PubMed - indexed for MEDLINE]Related articlesFree article

MCM-GINS and MCM-MCM interactions in vivo visualised by bimolecular fluorescence complementation in fission yeast.

Akman G, MacNeill SA.

BMC Cell Biol. 2009 Feb 19;10:12.PMID: 19228417 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.

Ilves I, Petojevic T, Pesavento JJ, Botchan MR.

Mol Cell. 2010 Jan 29;37(2):247-58.PMID: 20122406 [PubMed - indexed for MEDLINE]Related articles

DNA unwinding is an Mcm complex-dependent and ATP hydrolysis-dependent process.

Shechter D, Ying CY, Gautier J.

J Biol Chem. 2004 Oct 29;279(44):45586-93. Epub 2004 Aug 23.PMID: 15326181 [PubMed - indexed for MEDLINE]Related articlesFree article

A key role for the GINS complex at DNA replication forks.

Labib K, Gambus A.

Trends Cell Biol. 2007 Jun;17(6):271-8. Epub 2007 Apr 30. Review.PMID: 17467990 [PubMed - indexed for MEDLINE]Related articles

Mcm subunits can assemble into two different active unwinding complexes.

Kanter DM, Bruck I, Kaplan DL.

J Biol Chem. 2008 Nov 7;283(45):31172-82. Epub 2008 Sep 17.PMID: 18801730 [PubMed - indexed for MEDLINE]Related articlesFree article

Methods to study how replication fork helicases unwind DNA.

Kaplan DL, Bruck I.

Methods Mol Biol. 2010;587:127-35.PMID: 20225146 [PubMed - in process]Related articles

Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication.

Pacek M, Tutter AV, Kubota Y, Takisawa H, Walter JC.

Mol Cell. 2006 Feb 17;21(4):581-7.PMID: 16483939 [PubMed - indexed for MEDLINE]Related articles

Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase.

Bauerschmidt C, Pollok S, Kremmer E, Nasheuer HP, Grosse F.

Genes Cells. 2007 Jun;12(6):745-58.PMID: 17573775 [PubMed - indexed for MEDLINE]Related articles

MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication.

Xu X, Rochette PJ, Feyissa EA, Su TV, Liu Y.

EMBO J. 2009 Oct 7;28(19):3005-14. Epub 2009 Aug 20.PMID: 19696745 [PubMed - indexed for MEDLINE]Related articles

A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication.

Pacek M, Walter JC.

EMBO J. 2004 Sep 15;23(18):3667-76. Epub 2004 Aug 26.PMID: 15329670 [PubMed - indexed for MEDLINE]Related articlesFree article

The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding.

Ying CY, Gautier J.

EMBO J. 2005 Dec 21;24(24):4334-44. Epub 2005 Nov 24.PMID: 16369567 [PubMed - indexed for MEDLINE]Related articlesFree article

The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication.

Aparicio T, Guillou E, Coloma J, Montoya G, Méndez J.

Nucleic Acids Res. 2009 Apr;37(7):2087-95. Epub 2009 Feb 17.PMID: 19223333 [PubMed - indexed for MEDLINE]Related articlesFree article