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Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family.

Cam JA, Bu G.

Mol Neurodegener. 2006 Aug 18;1:8.PMID: 16930455 [PubMed]Related articlesFree article

Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease.

Marzolo MP, Bu G.

Semin Cell Dev Biol. 2009 Apr;20(2):191-200. Epub 2008 Oct 17. Review.PMID: 19041409 [PubMed - indexed for MEDLINE]Related articles

Functional role of lipoprotein receptors in Alzheimer's disease.

Jaeger S, Pietrzik CU.

Curr Alzheimer Res. 2008 Feb;5(1):15-25. Review.PMID: 18288927 [PubMed - indexed for MEDLINE]Related articles

LRP in amyloid-beta production and metabolism.

Bu G, Cam J, Zerbinatti C.

Ann N Y Acad Sci. 2006 Nov;1086:35-53. Review.PMID: 17185504 [PubMed - indexed for MEDLINE]Related articles

The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments.

Offe K, Dodson SE, Shoemaker JT, Fritz JJ, Gearing M, Levey AI, Lah JJ.

J Neurosci. 2006 Feb 1;26(5):1596-603.PMID: 16452683 [PubMed - indexed for MEDLINE]Related articlesFree article

The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production.

Cam JA, Zerbinatti CV, Knisely JM, Hecimovic S, Li Y, Bu G.

J Biol Chem. 2004 Jul 9;279(28):29639-46. Epub 2004 May 4.PMID: 15126508 [PubMed - indexed for MEDLINE]Related articlesFree article

Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition.

Harris-White ME, Frautschy SA.

Curr Drug Targets CNS Neurol Disord. 2005 Oct;4(5):469-80. Review.PMID: 16266282 [PubMed - indexed for MEDLINE]Related articles

Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.

Ulery PG, Beers J, Mikhailenko I, Tanzi RE, Rebeck GW, Hyman BT, Strickland DK.

J Biol Chem. 2000 Mar 10;275(10):7410-5.PMID: 10702315 [PubMed - indexed for MEDLINE]Related articlesFree article

LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP.

Moir RD, Tanzi RE.

Curr Alzheimer Res. 2005 Apr;2(2):269-73.PMID: 15974929 [PubMed - indexed for MEDLINE]Related articles

LRP and Alzheimer's disease.

Zerbinatti CV, Bu G.

Rev Neurosci. 2005;16(2):123-35. Review.PMID: 15959937 [PubMed - indexed for MEDLINE]Related articles

Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway.

Yoon IS, Chen E, Busse T, Repetto E, Lakshmana MK, Koo EH, Kang DE.

FASEB J. 2007 Sep;21(11):2742-52. Epub 2007 Apr 26.PMID: 17463224 [PubMed - indexed for MEDLINE]Related articlesFree article

Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention.

Ma QL, Teter B, Ubeda OJ, Morihara T, Dhoot D, Nyby MD, Tuck ML, Frautschy SA, Cole GM.

J Neurosci. 2007 Dec 26;27(52):14299-307.PMID: 18160637 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein.

Cam JA, Zerbinatti CV, Li Y, Bu G.

J Biol Chem. 2005 Apr 15;280(15):15464-70. Epub 2005 Feb 10.PMID: 15705569 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease.

Dodson SE, Andersen OM, Karmali V, Fritz JJ, Cheng D, Peng J, Levey AI, Willnow TE, Lah JJ.

J Neurosci. 2008 Nov 26;28(48):12877-86.PMID: 19036982 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional role of the low-density lipoprotein receptor-related protein in Alzheimer's disease.

Waldron E, Jaeger S, Pietrzik CU.

Neurodegener Dis. 2006;3(4-5):233-8. Review.PMID: 17047362 [PubMed - indexed for MEDLINE]Related articles

Novel modulators of amyloid-beta precursor protein processing.

Tang BL, Liou YC.

J Neurochem. 2007 Jan;100(2):314-23. Review.PMID: 17241154 [PubMed - indexed for MEDLINE]Related articles

Molecular and cellular mechanisms for Alzheimer's disease: understanding APP metabolism.

Zhang YW, Xu H.

Curr Mol Med. 2007 Nov;7(7):687-96. Review.PMID: 18045146 [PubMed - indexed for MEDLINE]Related articles

Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP).

Knauer MF, Orlando RA, Glabe CG.

Brain Res. 1996 Nov 18;740(1-2):6-14.PMID: 8973792 [PubMed - indexed for MEDLINE]Related articles

Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors.

Sambamurti K, Granholm AC, Kindy MS, Bhat NR, Greig NH, Lahiri DK, Mintzer JE.

Curr Drug Targets. 2004 Aug;5(6):517-28. Review.PMID: 15270198 [PubMed - indexed for MEDLINE]Related articles

Apolipoprotein receptor 2 and X11 alpha/beta mediate apolipoprotein E-induced endocytosis of amyloid-beta precursor protein and beta-secretase, leading to amyloid-beta production.

He X, Cooley K, Chung CH, Dashti N, Tang J.

J Neurosci. 2007 Apr 11;27(15):4052-60.PMID: 17428983 [PubMed - indexed for MEDLINE]Related articlesFree article