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    Results: 1 to 20 of 121

    1.

    Pathological and physiological functions of presenilins.

    Vetrivel KS, Zhang YW, Xu H, Thinakaran G.

    Mol Neurodegener. 2006 Jun 12;1:4.PMID: 16930451 [PubMed]Related articlesFree article

    2.

    Identification of the role of presenilins beyond Alzheimer's disease.

    Thinakaran G, Parent AT.

    Pharmacol Res. 2004 Oct;50(4):411-8. Review.PMID: 15304238 [PubMed - indexed for MEDLINE]Related articles

    3.

    Familial Alzheimer's Disease Mutations in Presenilin 1 Do Not Alter Levels of the Secreted Amyloid-beta Protein Precursor Generated by beta-Secretase Cleavage.

    Zhang C, Browne A, Kim DY, Tanzi RE.

    Curr Alzheimer Res. 2009 Dec 1. [Epub ahead of print]PMID: 19715549 [PubMed - as supplied by publisher]Related articles

    4.

    Familial Alzheimer's Disease Mutations in Presenilin 1 Do Not Alter Levels of the Secreted Amyloid-beta Protein Precursor Generated by beta-Secretase Cleavage.

    Zhang C, Browne A, Kim DY, Tanzi RE.

    Curr Alzheimer Res. 2010 Feb 1;7(1):21-6.PMID: 20205669 [PubMed - in process]Related articles

    5.

    The molecular link between beta- and gamma-secretase activity on the amyloid beta precursor protein.

    Tabaton M, Tamagno E.

    Cell Mol Life Sci. 2007 Sep;64(17):2211-8. Review.PMID: 17604999 [PubMed - indexed for MEDLINE]Related articles

    6.

    Novel class of polytopic proteins with domains associated with putative protease activity.

    Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev EI.

    Biochemistry (Mosc). 2002 Jul;67(7):826-35.PMID: 12139484 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.

    Fluhrer R, Fukumori A, Martin L, Grammer G, Haug-Kröper M, Klier B, Winkler E, Kremmer E, Condron MM, Teplow DB, Steiner H, Haass C.

    J Biol Chem. 2008 Oct 31;283(44):30121-8. Epub 2008 Sep 3.PMID: 18768471 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Protease digestion indicates that endogenous presenilin 1 is present in at least two physical forms.

    Oh YS, Turner RJ.

    Biochem Biophys Res Commun. 2006 Jul 21;346(1):330-4. Epub 2006 May 30.PMID: 16756946 [PubMed - indexed for MEDLINE]Related articles

    9.

    [Molecular basics of Alzheimer's disease]

    Grigorenko AP, Rogaev EI.

    Mol Biol (Mosk). 2007 Mar-Apr;41(2):331-45. Review. Russian. PMID: 17514900 [PubMed - indexed for MEDLINE]Related articles

    10.

    Variations in the neuropathology of familial Alzheimer's disease.

    Shepherd C, McCann H, Halliday GM.

    Acta Neuropathol. 2009 Jul;118(1):37-52. Epub 2009 Mar 22. Review.PMID: 19306098 [PubMed - indexed for MEDLINE]Related articles

    11.

    Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.

    Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A.

    Neurosci Res. 2007 Mar;57(3):446-53. Epub 2007 Jan 8.PMID: 17210196 [PubMed - indexed for MEDLINE]Related articles

    12.

    Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.

    Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A.

    J Biol Chem. 2008 Jun 13;283(24):16488-96. Epub 2008 Apr 21.PMID: 18430735 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Alzheimer disease: amyloidogenesis, the presenilins and animal models.

    Newman M, Musgrave IF, Lardelli M.

    Biochim Biophys Acta. 2007 Mar;1772(3):285-97. Epub 2006 Dec 8. Review. Erratum in: Biochim Biophys Acta. 2007 Sep;1772(9):1118. Musgrave, F I [corrected to Musgrave, I F]. PMID: 17208417 [PubMed - indexed for MEDLINE]Related articles

    14.

    Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.

    Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H.

    Neurobiol Dis. 2007 Jul;27(1):102-7. Epub 2007 May 6.PMID: 17560791 [PubMed - indexed for MEDLINE]Related articles

    15.

    Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.

    Futai E, Yagishita S, Ishiura S.

    J Biol Chem. 2009 May 8;284(19):13013-22. Epub 2009 Mar 2.PMID: 19254953 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1.

    Nelson O, Tu H, Lei T, Bentahir M, de Strooper B, Bezprozvanny I.

    J Clin Invest. 2007 May;117(5):1230-9. Epub 2007 Apr 12.PMID: 17431506 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations.

    Maarouf CL, Daugs ID, Spina S, Vidal R, Kokjohn TA, Patton RL, Kalback WM, Luehrs DC, Walker DG, Castaño EM, Beach TG, Ghetti B, Roher AE.

    Mol Neurodegener. 2008 Nov 20;3:20.PMID: 19021905 [PubMed - in process]Related articlesFree article

    18.

    What is 'early onset dementia'?

    Miyoshi K.

    Psychogeriatrics. 2009 Jun;9(2):67-72. Review.PMID: 19604328 [PubMed - indexed for MEDLINE]Related articles

    19.

    Genetic aspects of Alzheimer's disease.

    Zekanowski C, Religa D, Graff C, Filipek S, Kuźnicki J.

    Acta Neurobiol Exp (Wars). 2004;64(1):19-31. Review.PMID: 15190677 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism.

    Shen J, Kelleher RJ 3rd.

    Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):403-9. Epub 2006 Dec 29. Review.PMID: 17197420 [PubMed - indexed for MEDLINE]Related articlesFree article

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