PubMed

The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs.

Smith KA.

Med Immunol. 2006 Aug 14;5:3.PMID: 16907989 [PubMed]Related articlesFree article

Interleukin-2 receptor signaling in regulatory T cell development and homeostasis.

Burchill MA, Yang J, Vang KB, Farrar MA.

Immunol Lett. 2007 Nov 30;114(1):1-8. Epub 2007 Sep 14. Review.PMID: 17936914 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural studies of the interleukin-19 subfamily of cytokines.

Zdanov A.

Vitam Horm. 2006;74:61-76. Review.PMID: 17027511 [PubMed - indexed for MEDLINE]Related articles

Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cells.

de Bakker BI, Bodnár A, van Dijk EM, Vámosi G, Damjanovich S, Waldmann TA, van Hulst NF, Jenei A, Garcia-Parajo MF.

J Cell Sci. 2008 Mar 1;121(Pt 5):627-33.PMID: 18287585 [PubMed - indexed for MEDLINE]Related articlesFree article

Elucidation of the interleukin-15 binding site on its alpha receptor by NMR.

Hanick NA, Rickert M, Varani L, Bankovich AJ, Cochran JR, Kim DM, Surh CD, Garcia KC.

Biochemistry. 2007 Aug 21;46(33):9453-61. Epub 2007 Jul 27.PMID: 17655329 [PubMed - indexed for MEDLINE]Related articles

Structure of IL-22 bound to its high-affinity IL-22R1 chain.

Jones BC, Logsdon NJ, Walter MR.

Structure. 2008 Sep 10;16(9):1333-44. Epub 2008 Jul 3.PMID: 18599299 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural basis of receptor sharing by interleukin 17 cytokines.

Ely LK, Fischer S, Garcia KC.

Nat Immunol. 2009 Dec;10(12):1245-51. Epub 2009 Oct 18.PMID: 19838198 [PubMed - indexed for MEDLINE]Related articles

Biphasic regulation of Il2 transcription in CD4+ T cells: roles for TNF-alpha receptor signaling and chromatin structure.

McKarns SC, Schwartz RH.

J Immunol. 2008 Jul 15;181(2):1272-81.PMID: 18606681 [PubMed - indexed for MEDLINE]Related articlesFree article

An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3.

Feng X, Müller T, Mizrachi D, Fanelli F, Segaloff DL.

Endocrinology. 2008 Apr;149(4):1705-17. Epub 2007 Dec 27.PMID: 18162522 [PubMed - indexed for MEDLINE]Related articlesFree article

A chimera of interleukin 2 and a binding variant of aerolysin is selectively toxic to cells displaying the interleukin 2 receptor.

Osusky M, Teschke L, Wang X, Wong K, Buckley JT.

J Biol Chem. 2008 Jan 18;283(3):1572-9. Epub 2007 Nov 2.PMID: 17981806 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130.

Tenhumberg S, Waetzig GH, Chalaris A, Rabe B, Seegert D, Scheller J, Rose-John S, Grötzinger J.

J Biol Chem. 2008 Oct 3;283(40):27200-7. Epub 2008 Jul 23.PMID: 18650419 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-3, IL-5, and GM-CSF signaling: crystal structure of the human beta-common receptor.

Murphy JM, Young IG.

Vitam Horm. 2006;74:1-30. Review.PMID: 17027509 [PubMed - indexed for MEDLINE]Related articles

Overview of resistance to systemic therapy in patients with breast cancer.

Gonzalez-Angulo AM, Morales-Vasquez F, Hortobagyi GN.

Adv Exp Med Biol. 2007;608:1-22. Review.PMID: 17993229 [PubMed - indexed for MEDLINE]Related articles

IL-2 regulates CD103 expression on CD4+ T cells in Scurfy mice that display both CD103-dependent and independent inflammation.

Sharma R, Sung SS, Abaya CE, Ju AC, Fu SM, Ju ST.

J Immunol. 2009 Jul 15;183(2):1065-73. Epub 2009 Jun 24.PMID: 19553521 [PubMed - indexed for MEDLINE]Related articles

Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22.

de Moura PR, Watanabe L, Bleicher L, Colau D, Dumoutier L, Lemaire MM, Renauld JC, Polikarpov I.

FEBS Lett. 2009 Apr 2;583(7):1072-7. Epub 2009 Mar 11.PMID: 19285080 [PubMed - indexed for MEDLINE]Related articles

Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation.

Olsen SK, Ota N, Kishishita S, Kukimoto-Niino M, Murayama K, Uchiyama H, Toyama M, Terada T, Shirouzu M, Kanagawa O, Yokoyama S.

J Biol Chem. 2007 Dec 21;282(51):37191-204. Epub 2007 Oct 18.PMID: 17947230 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunogenicity of the hu14.18-IL2 immunocytokine molecule in adults with melanoma and children with neuroblastoma.

Hank JA, Gan J, Ryu H, Ostendorf A, Stauder MC, Sternberg A, Albertini M, Lo KM, Gillies SD, Eickhoff J, Sondel PM.

Clin Cancer Res. 2009 Sep 15;15(18):5923-30. Epub 2009 Sep 8.PMID: 19737959 [PubMed - in process]Related articles

Genome wide transcriptional analysis of resting and IL2 activated human natural killer cells: gene expression signatures indicative of novel molecular signaling pathways.

Dybkaer K, Iqbal J, Zhou G, Geng H, Xiao L, Schmitz A, d'Amore F, Chan WC.

BMC Genomics. 2007 Jul 10;8:230.PMID: 17623099 [PubMed - indexed for MEDLINE]Related articlesFree article

Debate: Does genetic information in humans help us treat patients? PRO--genetic information in humans helps us treat patients. CON--genetic information does not help at all.

Delgado-Escueta AV, Bourgeois BF.

Epilepsia. 2008 Dec;49 Suppl 9:13-24. Review.PMID: 19087113 [PubMed - indexed for MEDLINE]Related articles

Unusual water-mediated antigenic recognition of the proinflammatory cytokine interleukin-18.

Argiriadi MA, Xiang T, Wu C, Ghayur T, Borhani DW.

J Biol Chem. 2009 Sep 4;284(36):24478-89. Epub 2009 Jun 24.PMID: 19553661 [PubMed - indexed for MEDLINE]Related articles