PubMed

Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants.

Sun D, Chen G, Dellinger RW, Duncan K, Fang JL, Lazarus P.

Breast Cancer Res. 2006;8(4):R50.PMID: 16884532 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases.

Sun D, Sharma AK, Dellinger RW, Blevins-Primeau AS, Balliet RM, Chen G, Boyiri T, Amin S, Lazarus P.

Drug Metab Dispos. 2007 Nov;35(11):2006-14. Epub 2007 Jul 30.PMID: 17664247 [PubMed - indexed for MEDLINE]Related articlesFree article

Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4.

Ogura K, Ishikawa Y, Kaku T, Nishiyama T, Ohnuma T, Muro K, Hiratsuka A.

Biochem Pharmacol. 2006 Apr 28;71(9):1358-69. Epub 2006 Feb 14.PMID: 16480962 [PubMed - indexed for MEDLINE]Related articles

Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites.

Blevins-Primeau AS, Sun D, Chen G, Sharma AK, Gallagher CJ, Amin S, Lazarus P.

Cancer Res. 2009 Mar 1;69(5):1892-900. Epub 2009 Feb 24.PMID: 19244109 [PubMed - indexed for MEDLINE]Related articlesFree article

Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4.

Kaku T, Ogura K, Nishiyama T, Ohnuma T, Muro K, Hiratsuka A.

Biochem Pharmacol. 2004 Jun 1;67(11):2093-102.PMID: 15135306 [PubMed - indexed for MEDLINE]Related articles

Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronidation phenotype in human liver microsomes.

Wiener D, Fang JL, Dossett N, Lazarus P.

Cancer Res. 2004 Feb 1;64(3):1190-6. Erratum in: Cancer Res. 2004 Mar 1;64(5):1899. PMID: 14871856 [PubMed - indexed for MEDLINE]Related articlesFree article

Reverse geometrical selectivity in glucuronidation and sulfation of cis- and trans-4-hydroxytamoxifens by human liver UDP-glucuronosyltransferases and sulfotransferases.

Nishiyama T, Ogura K, Nakano H, Ohnuma T, Kaku T, Hiratsuka A, Muro K, Watabe T.

Biochem Pharmacol. 2002 May 15;63(10):1817-30.PMID: 12034366 [PubMed - indexed for MEDLINE]Related articles

Elimination of antiestrogenic effects of active tamoxifen metabolites by glucuronidation.

Zheng Y, Sun D, Sharma AK, Chen G, Amin S, Lazarus P.

Drug Metab Dispos. 2007 Oct;35(10):1942-8. Epub 2007 Jul 9.PMID: 17620345 [PubMed - indexed for MEDLINE]Related articlesFree article

Trans-3'-hydroxycotinine O- and N-glucuronidations in human liver microsomes.

Yamanaka H, Nakajima M, Katoh M, Kanoh A, Tamura O, Ishibashi H, Yokoi T.

Drug Metab Dispos. 2005 Jan;33(1):23-30. Epub 2004 Oct 6.PMID: 15470160 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism.

Chen G, Blevins-Primeau AS, Dellinger RW, Muscat JE, Lazarus P.

Cancer Res. 2007 Oct 1;67(19):9024-9.PMID: 17909004 [PubMed - indexed for MEDLINE]Related articlesFree article

Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform.

Dellinger RW, Fang JL, Chen G, Weinberg R, Lazarus P.

Drug Metab Dispos. 2006 Jun;34(6):943-9. Epub 2006 Mar 1.PMID: 16510539 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterizing the effects of common UDP glucuronosyltransferase (UGT) 1A6 and UGT1A1 polymorphisms on cis- and trans-resveratrol glucuronidation.

Iwuchukwu OF, Ajetunmobi J, Ung D, Nagar S.

Drug Metab Dispos. 2009 Aug;37(8):1726-32. Epub 2009 Apr 30.PMID: 19406951 [PubMed - indexed for MEDLINE]Related articles

Characterization of benzo(a)pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes.

Fang JL, Beland FA, Doerge DR, Wiener D, Guillemette C, Marques MM, Lazarus P.

Cancer Res. 2002 Apr 1;62(7):1978-86. Erratum in: Cancer Res 2002 Jun 1;62(11):3328. PMID: 11929814 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of UGTs active against SAHA and association between SAHA glucuronidation activity phenotype with UGT genotype.

Balliet RM, Chen G, Gallagher CJ, Dellinger RW, Sun D, Lazarus P.

Cancer Res. 2009 Apr 1;69(7):2981-9. Epub 2009 Mar 24.PMID: 19318555 [PubMed - indexed for MEDLINE]Related articles

Characterization of afloqualone N-glucuronidation: species differences and identification of human UDP-glucuronosyltransferase isoform(s).

Kaji H, Kume T.

Drug Metab Dispos. 2005 Jan;33(1):60-7. Epub 2004 Oct 8.PMID: 15475412 [PubMed - indexed for MEDLINE]Related articlesFree article

Imipramine N-glucuronidation in human liver microsomes: biphasic kinetics and characterization of UDP-glucuronosyltransferase isoforms.

Nakajima M, Tanaka E, Kobayashi T, Ohashi N, Kume T, Yokoi T.

Drug Metab Dispos. 2002 Jun;30(6):636-42.PMID: 12019188 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucuronidation of tobacco-specific nitrosamines by UGT2B10.

Chen G, Dellinger RW, Sun D, Spratt TE, Lazarus P.

Drug Metab Dispos. 2008 May;36(5):824-30. Epub 2008 Jan 31.PMID: 18238858 [PubMed - indexed for MEDLINE]Related articlesFree article

N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases.

Ghosheh O, Hawes EM.

Drug Metab Dispos. 2002 Sep;30(9):991-6.PMID: 12167564 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucuronidation of dihydrotestosterone and trans-androsterone by recombinant UDP-glucuronosyltransferase (UGT) 1A4: evidence for multiple UGT1A4 aglycone binding sites.

Zhou J, Tracy TS, Remmel RP.

Drug Metab Dispos. 2010 Mar;38(3):431-40. Epub 2009 Dec 9.PMID: 20007295 [PubMed - in process]Related articles

Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation.

Hashizume T, Xu Y, Mohutsky MA, Alberts J, Hadden C, Kalhorn TF, Isoherranen N, Shuhart MC, Thummel KE.

Biochem Pharmacol. 2008 Mar 1;75(5):1240-50. Epub 2007 Nov 22.PMID: 18177842 [PubMed - indexed for MEDLINE]Related articlesFree article