PubMed

Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin.

Draznin B.

Diabetes. 2006 Aug;55(8):2392-7. Review.PMID: 16873706 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents.

Qiao LY, Zhande R, Jetton TL, Zhou G, Sun XJ.

J Biol Chem. 2002 Jul 19;277(29):26530-9. Epub 2002 May 2.PMID: 12006586 [PubMed - indexed for MEDLINE]Related articlesFree article

Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 kinase (S6K1) pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of p85alpha subunit of phosphatidylinositol 3-kinase and S6K1 kinase.

Adochio R, Leitner JW, Hedlund R, Draznin B.

Endocrinology. 2009 Mar;150(3):1165-73. Epub 2008 Oct 23.PMID: 18948408 [PubMed - indexed for MEDLINE]Related articles

Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes.

Gao Z, Zhang X, Zuberi A, Hwang D, Quon MJ, Lefevre M, Ye J.

Mol Endocrinol. 2004 Aug;18(8):2024-34. Epub 2004 May 13.PMID: 15143153 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of insulin receptor substrate-1 (IRS-1) with phosphatidylinositol 3-kinase: effect of substitution of serine for alanine in potential IRS-1 serine phosphorylation sites.

Delahaye L, Mothe-Satney I, Myers MG, White MF, Van Obberghen E.

Endocrinology. 1998 Dec;139(12):4911-9.PMID: 9832428 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular mechanism(s) of burn-induced insulin resistance in murine skeletal muscle: role of IRS phosphorylation.

Zhang Q, Carter EA, Ma BY, White M, Fischman AJ, Tompkins RG.

Life Sci. 2005 Oct 28;77(24):3068-77. Epub 2005 Jun 27.PMID: 15982669 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes.

He J, Usui I, Ishizuka K, Kanatani Y, Hiratani K, Iwata M, Bukhari A, Haruta T, Sasaoka T, Kobayashi M.

Mol Endocrinol. 2006 Jan;20(1):114-24. Epub 2005 Sep 8.PMID: 16150868 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance.

Kim JA, Yeh DC, Ver M, Li Y, Carranza A, Conrads TP, Veenstra TD, Harrington MA, Quon MJ.

J Biol Chem. 2005 Jun 17;280(24):23173-83. Epub 2005 Apr 22.PMID: 15849359 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased insulin receptor substrate 1 serine phosphorylation and stress-activated protein kinase/c-Jun N-terminal kinase activation associated with vascular insulin resistance in spontaneously hypertensive rats.

Sugita M, Sugita H, Kaneki M.

Hypertension. 2004 Oct;44(4):484-9. Epub 2004 Aug 9.PMID: 15302844 [PubMed - indexed for MEDLINE]Related articlesFree article

Alteration in insulin action: role of IRS-1 serine phosphorylation in the retroregulation of insulin signalling.

Tanti JF, Gual P, Grémeaux T, Gonzalez T, Barrès R, Le Marchand-Brustel Y.

Ann Endocrinol (Paris). 2004 Feb;65(1):43-8. Review.PMID: 15122091 [PubMed - indexed for MEDLINE]Related articles

Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance.

Liu YF, Herschkovitz A, Boura-Halfon S, Ronen D, Paz K, Leroith D, Zick Y.

Mol Cell Biol. 2004 Nov;24(21):9668-81.PMID: 15485932 [PubMed - indexed for MEDLINE]Related articlesFree article

Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling.

Liberman Z, Eldar-Finkelman H.

J Biol Chem. 2005 Feb 11;280(6):4422-8. Epub 2004 Nov 30.PMID: 15574412 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes.

Bouzakri K, Roques M, Gual P, Espinosa S, Guebre-Egziabher F, Riou JP, Laville M, Le Marchand-Brustel Y, Tanti JF, Vidal H.

Diabetes. 2003 Jun;52(6):1319-25.PMID: 12765939 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.

Gual P, Gonzalez T, Grémeaux T, Barres R, Le Marchand-Brustel Y, Tanti JF.

J Biol Chem. 2003 Jul 18;278(29):26550-7. Epub 2003 May 1.PMID: 12730242 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes.

Müssig K, Fiedler H, Staiger H, Weigert C, Lehmann R, Schleicher ED, Häring HU.

Biochem Biophys Res Commun. 2005 Sep 30;335(3):819-25.PMID: 16099431 [PubMed - indexed for MEDLINE]Related articles

JAK1-dependent phosphorylation of insulin receptor substrate-1 (IRS-1) is inhibited by IRS-1 serine phosphorylation.

Cengel KA, Freund GG.

J Biol Chem. 1999 Sep 24;274(39):27969-74.PMID: 10488146 [PubMed - indexed for MEDLINE]Related articlesFree article

MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632.

Gual P, Grémeaux T, Gonzalez T, Le Marchand-Brustel Y, Tanti JF.

Diabetologia. 2003 Nov;46(11):1532-42. Epub 2003 Oct 25.PMID: 14579029 [PubMed - indexed for MEDLINE]Related articles

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

Gao Z, Hwang D, Bataille F, Lefevre M, York D, Quon MJ, Ye J.

J Biol Chem. 2002 Dec 13;277(50):48115-21. Epub 2002 Sep 25.PMID: 12351658 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway.

Ueno M, Carvalheira JB, Tambascia RC, Bezerra RM, Amaral ME, Carneiro EM, Folli F, Franchini KG, Saad MJ.

Diabetologia. 2005 Mar;48(3):506-18. Epub 2005 Feb 4.PMID: 15692808 [PubMed - indexed for MEDLINE]Related articles

Phosphatidylinositol 3-kinase redistribution is associated with skeletal muscle insulin resistance in gestational diabetes mellitus.

Shao J, Yamashita H, Qiao L, Draznin B, Friedman JE.

Diabetes. 2002 Jan;51(1):19-29.PMID: 11756318 [PubMed - indexed for MEDLINE]Related articlesFree article