PubMed

Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects.

Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM.

Diabetes. 2006 Aug;55(8):2277-85.PMID: 16873691 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation.

Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang Cc C, Itani SI, Lodish HF, Ruderman NB.

Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16309-13. Epub 2002 Nov 27.PMID: 12456889 [PubMed - indexed for MEDLINE]Related articlesFree article

LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle.

Thomson DM, Brown JD, Fillmore N, Condon BM, Kim HJ, Barrow JR, Winder WW.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1572-9. Epub 2007 Oct 9.PMID: 17925454 [PubMed - indexed for MEDLINE]Related articlesFree article

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-induced AMP-activated protein kinase phosphorylation inhibits basal and insulin-stimulated glucose uptake, lipid synthesis, and fatty acid oxidation in isolated rat adipocytes.

Gaidhu MP, Fediuc S, Ceddia RB.

J Biol Chem. 2006 Sep 8;281(36):25956-64. Epub 2006 Jul 1.PMID: 16816404 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK and ACC phosphorylation: effect of leptin, muscle fibre type and obesity.

Janovská A, Hatzinikolas G, Staikopoulos V, McInerney J, Mano M, Wittert GA.

Mol Cell Endocrinol. 2008 Mar 12;284(1-2):1-10. Epub 2008 Jan 3.PMID: 18255222 [PubMed - indexed for MEDLINE]Related articles

Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA.

Bell JA, Volpi E, Fujita S, Cadenas JG, Rasmussen BB.

Diabetologia. 2006 Sep;49(9):2144-52. Epub 2006 Jul 26.PMID: 16868746 [PubMed - indexed for MEDLINE]Related articles

High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase.

Kudo N, Barr AJ, Barr RL, Desai S, Lopaschuk GD.

J Biol Chem. 1995 Jul 21;270(29):17513-20.PMID: 7615556 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats.

Kraegen EW, Saha AK, Preston E, Wilks D, Hoy AJ, Cooney GJ, Ruderman NB.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E471-9. Epub 2005 Oct 18.PMID: 16234268 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential mechanisms and consequences of cardiac triacylglycerol accumulation in insulin-resistant rats.

Atkinson LL, Kozak R, Kelly SE, Onay Besikci A, Russell JC, Lopaschuk GD.

Am J Physiol Endocrinol Metab. 2003 May;284(5):E923-30. Epub 2002 Dec 3.PMID: 12464581 [PubMed - indexed for MEDLINE]Related articlesFree article

Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial.

Coletta DK, Sriwijitkamol A, Wajcberg E, Tantiwong P, Li M, Prentki M, Madiraju M, Jenkinson CP, Cersosimo E, Musi N, Defronzo RA.

Diabetologia. 2009 Apr;52(4):723-32. Epub 2009 Jan 24.PMID: 19169664 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase regulation of fatty acid oxidation in the ischaemic heart.

Hopkins TA, Dyck JR, Lopaschuk GD.

Biochem Soc Trans. 2003 Feb;31(Pt 1):207-12. Review.PMID: 12546686 [PubMed - indexed for MEDLINE]Related articles

MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats.

Atkinson LL, Kelly SE, Russell JC, Bar-Tana J, Lopaschuk GD.

Diabetes. 2002 May;51(5):1548-55.PMID: 11978655 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation.

Båvenholm PN, Kuhl J, Pigon J, Saha AK, Ruderman NB, Efendic S.

J Clin Endocrinol Metab. 2003 Jan;88(1):82-7. Erratum in: J Clin Endocrinol Metab. 2003 May;88(5):2036. PMID: 12519834 [PubMed - indexed for MEDLINE]Related articlesFree article

Contribution of malonyl-CoA decarboxylase to the high fatty acid oxidation rates seen in the diabetic heart.

Sakamoto J, Barr RL, Kavanagh KM, Lopaschuk GD.

Am J Physiol Heart Circ Physiol. 2000 Apr;278(4):H1196-204.PMID: 10749714 [PubMed - indexed for MEDLINE]Related articlesFree article

Malonyl CoA control of fatty acid oxidation in the newborn heart in response to increased fatty acid supply.

Onay-Besikci A, Sambandam N.

Can J Physiol Pharmacol. 2006 Nov;84(11):1215-22.PMID: 17218986 [PubMed - indexed for MEDLINE]Related articles

Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac power.

King KL, Okere IC, Sharma N, Dyck JR, Reszko AE, McElfresh TA, Kerner J, Chandler MP, Lopaschuk GD, Stanley WC.

Am J Physiol Heart Circ Physiol. 2005 Sep;289(3):H1033-7. Epub 2005 Apr 8.PMID: 15821035 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged exposure to palmitate impairs fatty acid oxidation despite activation of AMP-activated protein kinase in skeletal muscle cells.

Pimenta AS, Gaidhu MP, Habib S, So M, Fediuc S, Mirpourian M, Musheev M, Curi R, Ceddia RB.

J Cell Physiol. 2008 Nov;217(2):478-85.PMID: 18561258 [PubMed - indexed for MEDLINE]Related articles

Insulin stimulation of glucose uptake fails to decrease palmitate oxidation in muscle if AMPK is activated.

Winder WW, Holmes BF.

J Appl Physiol. 2000 Dec;89(6):2430-7.PMID: 11090599 [PubMed - indexed for MEDLINE]Related articlesFree article

Malonyl CoA, long chain fatty acyl CoA and insulin resistance in skeletal muscle.

Ruderman NB, Dean D.

J Basic Clin Physiol Pharmacol. 1998;9(2-4):295-308. Review.PMID: 10212840 [PubMed - indexed for MEDLINE]Related articles

Fatty acid oxidation and the regulation of malonyl-CoA in human muscle.

Båvenholm PN, Pigon J, Saha AK, Ruderman NB, Efendic S.

Diabetes. 2000 Jul;49(7):1078-83.PMID: 10909961 [PubMed - indexed for MEDLINE]Related articlesFree article