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    Results: 1 to 20 of 666

    1.

    Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid.

    Estella E, McKenzie MD, Catterall T, Sutton VR, Bird PI, Trapani JA, Kay TW, Thomas HE.

    Diabetes. 2006 Aug;55(8):2212-9.PMID: 16873683 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

    Barry M, Heibein JA, Pinkoski MJ, Lee SF, Moyer RW, Green DR, Bleackley RC.

    Mol Cell Biol. 2000 Jun;20(11):3781-94.PMID: 10805722 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis.

    Waterhouse NJ, Sedelies KA, Sutton VR, Pinkoski MJ, Thia KY, Johnstone R, Bird PI, Green DR, Trapani JA.

    Cell Death Differ. 2006 Apr;13(4):607-18.PMID: 16167065 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Granzyme B-induced loss of mitochondrial inner membrane potential (Delta Psi m) and cytochrome c release are caspase independent.

    Heibein JA, Barry M, Motyka B, Bleackley RC.

    J Immunol. 1999 Nov 1;163(9):4683-93.PMID: 10528165 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis.

    MacDonald G, Shi L, Vande Velde C, Lieberman J, Greenberg AH.

    J Exp Med. 1999 Jan 4;189(1):131-44.PMID: 9874570 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin.

    Browne KA, Blink E, Sutton VR, Froelich CJ, Jans DA, Trapani JA.

    Mol Cell Biol. 1999 Dec;19(12):8604-15.PMID: 10567584 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis.

    Browne KA, Johnstone RW, Jans DA, Trapani JA.

    J Biol Chem. 2000 Dec 15;275(50):39262-6.PMID: 11050075 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells.

    Vermijlen D, Froelich CJ, Luo D, Suarez-Huerta N, Robaye B, Wisse E.

    Cancer Immunol Immunother. 2001 Jun;50(4):212-7.PMID: 11459173 [PubMed - indexed for MEDLINE]Related articles

    9.

    Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent.

    Trapani JA, Jans DA, Jans PJ, Smyth MJ, Browne KA, Sutton VR.

    J Biol Chem. 1998 Oct 23;273(43):27934-8.PMID: 9774406 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis.

    Metkar SS, Wang B, Ebbs ML, Kim JH, Lee YJ, Raja SM, Froelich CJ.

    J Cell Biol. 2003 Mar 17;160(6):875-85. Epub 2003 Mar 10.PMID: 12629051 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation.

    Choy JC, Hung VH, Hunter AL, Cheung PK, Motyka B, Goping IS, Sawchuk T, Bleackley RC, Podor TJ, McManus BM, Granville DJ.

    Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2245-50. Epub 2004 Oct 7.PMID: 15472125 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

    Sutton VR, Davis JE, Cancilla M, Johnstone RW, Ruefli AA, Sedelies K, Browne KA, Trapani JA.

    J Exp Med. 2000 Nov 20;192(10):1403-14.PMID: 11085743 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death.

    Sutton VR, Estella E, Li C, Chen M, Thomas HE, Kay TW, Trapani JA.

    Transplantation. 2006 Jan 27;81(2):146-54.PMID: 16436955 [PubMed - indexed for MEDLINE]Related articles

    14.

    Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells.

    Wang GQ, Wieckowski E, Goldstein LA, Gastman BR, Rabinovitz A, Gambotto A, Li S, Fang B, Yin XM, Rabinowich H.

    J Exp Med. 2001 Nov 5;194(9):1325-37.PMID: 11696597 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Granzyme M mediates a novel form of perforin-dependent cell death.

    Kelly JM, Waterhouse NJ, Cretney E, Browne KA, Ellis S, Trapani JA, Smyth MJ.

    J Biol Chem. 2004 May 21;279(21):22236-42. Epub 2004 Mar 17.PMID: 15028722 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    A central role for Bid in granzyme B-induced apoptosis.

    Waterhouse NJ, Sedelies KA, Browne KA, Wowk ME, Newbold A, Sutton VR, Clarke CJ, Oliaro J, Lindemann RK, Bird PI, Johnstone RW, Trapani JA.

    J Biol Chem. 2005 Feb 11;280(6):4476-82. Epub 2004 Dec 1.PMID: 15574417 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

    McKenzie MD, Carrington EM, Kaufmann T, Strasser A, Huang DC, Kay TW, Allison J, Thomas HE.

    Diabetes. 2008 May;57(5):1284-92. Epub 2008 Feb 5.PMID: 18252892 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.

    Sutton VR, Wowk ME, Cancilla M, Trapani JA.

    Immunity. 2003 Mar;18(3):319-29.PMID: 12648450 [PubMed - indexed for MEDLINE]Related articles

    19.

    Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis.

    Pinkoski MJ, Hobman M, Heibein JA, Tomaselli K, Li F, Seth P, Froelich CJ, Bleackley RC.

    Blood. 1998 Aug 1;92(3):1044-54.PMID: 9680374 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway.

    Vermijlen D, Luo D, Froelich CJ, Medema JP, Kummer JA, Willems E, Braet F, Wisse E.

    J Leukoc Biol. 2002 Oct;72(4):668-76.PMID: 12377935 [PubMed - indexed for MEDLINE]Related articlesFree article

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