PubMed

A conditional model reveals that induction of hepatocyte nuclear factor-1alpha in Hnf1alpha-null mutant beta-cells can activate silenced genes postnatally, whereas overexpression is deleterious.

Luco RF, Maestro MA, del Pozo N, Philbrick WM, de la Ossa PP, Ferrer J.

Diabetes. 2006 Aug;55(8):2202-11.PMID: 16873682 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells.

Yang Q, Yamagata K, Fukui K, Cao Y, Nammo T, Iwahashi H, Wang H, Matsumura I, Hanafusa T, Bucala R, Wollheim CB, Miyagawa J, Matsuzawa Y.

Diabetes. 2002 Jun;51(6):1785-92.PMID: 12031966 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of the liver fatty acid-binding protein gene by hepatocyte nuclear factor 1alpha (HNF1alpha). Alterations in fatty acid homeostasis in HNF1alpha-deficient mice.

Akiyama TE, Ward JM, Gonzalez FJ.

J Biol Chem. 2000 Sep 1;275(35):27117-22.PMID: 10852923 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.

Yamagata K, Nammo T, Moriwaki M, Ihara A, Iizuka K, Yang Q, Satoh T, Li M, Uenaka R, Okita K, Iwahashi H, Zhu Q, Cao Y, Imagawa A, Tochino Y, Hanafusa T, Miyagawa J, Matsuzawa Y.

Diabetes. 2002 Jan;51(1):114-23.PMID: 11756330 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional regulation of human and mouse organic anion transporter 1 by hepatocyte nuclear factor 1 alpha/beta.

Saji T, Kikuchi R, Kusuhara H, Kim I, Gonzalez FJ, Sugiyama Y.

J Pharmacol Exp Ther. 2008 Feb;324(2):784-90. Epub 2007 Nov 20.PMID: 18029548 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth.

Maestro MA, Cardalda C, Boj SF, Luco RF, Servitja JM, Ferrer J.

Endocr Dev. 2007;12:33-45. Review.PMID: 17923767 [PubMed - indexed for MEDLINE]Related articles

Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion.

Wang H, Maechler P, Antinozzi PA, Hagenfeldt KA, Wollheim CB.

J Biol Chem. 2000 Nov 17;275(46):35953-9.PMID: 10967120 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels.

Richter S, Shih DQ, Pearson ER, Wolfrum C, Fajans SS, Hattersley AT, Stoffel M.

Diabetes. 2003 Dec;52(12):2989-95.PMID: 14633861 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1alpha)-deficient mice.

Cheung C, Akiyama TE, Kudo G, Gonzalez FJ.

Biochem Pharmacol. 2003 Nov 15;66(10):2011-20.PMID: 14599559 [PubMed - indexed for MEDLINE]Related articles

Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver.

Servitja JM, Pignatelli M, Maestro MA, Cardalda C, Boj SF, Lozano J, Blanco E, Lafuente A, McCarthy MI, Sumoy L, Guigó R, Ferrer J.

Mol Cell Biol. 2009 Jun;29(11):2945-59. Epub 2009 Mar 16.PMID: 19289501 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes.

Laybutt DR, Weir GC, Kaneto H, Lebet J, Palmiter RD, Sharma A, Bonner-Weir S.

Diabetes. 2002 Jun;51(6):1793-804.PMID: 12031967 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice.

Hagenfeldt-Johansson KA, Herrera PL, Wang H, Gjinovci A, Ishihara H, Wollheim CB.

Endocrinology. 2001 Dec;142(12):5311-20.PMID: 11713231 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation.

Kikuchi R, Kusuhara H, Hattori N, Kim I, Shiota K, Gonzalez FJ, Sugiyama Y.

Mol Pharmacol. 2007 Dec;72(6):1619-25. Epub 2007 Sep 13.PMID: 17855651 [PubMed - indexed for MEDLINE]Related articlesFree article

Embryonic but not postnatal reexpression of hepatocyte nuclear factor 1alpha (HNF1alpha) can reactivate the silent phenylalanine hydroxylase gene in HNF1alpha-deficient hepatocytes.

Viollet B, Yaniv M, Pontoglio M.

Mol Cell Biol. 2001 Jun;21(11):3662-70.PMID: 11340160 [PubMed - indexed for MEDLINE]Related articlesFree article

A molecular link between the common phenotypes of type 1 glycogen storage disease and HNF1alpha-null mice.

Hiraiwa H, Pan CJ, Lin B, Akiyama TE, Gonzalez FJ, Chou JY.

J Biol Chem. 2001 Mar 16;276(11):7963-7. Epub 2000 Dec 19.PMID: 11121425 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective deletion of the Hnf1beta (MODY5) gene in beta-cells leads to altered gene expression and defective insulin release.

Wang L, Coffinier C, Thomas MK, Gresh L, Eddu G, Manor T, Levitsky LL, Yaniv M, Rhoads DB.

Endocrinology. 2004 Aug;145(8):3941-9. Epub 2004 May 13.PMID: 15142986 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted deficiency of the transcriptional activator Hnf1alpha alters subnuclear positioning of its genomic targets.

Luco RF, Maestro MA, Sadoni N, Zink D, Ferrer J.

PLoS Genet. 2008 May 23;4(5):e1000079.PMID: 18497863 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in hepatocyte nuclear factor 4alpha (HNF4alpha) gene associated with diabetes result in greater loss of HNF4alpha function in pancreatic beta-cells than in nonpancreatic beta-cells and in reduced activation of the apolipoprotein CIII promoter in hepatic cells.

Oxombre B, Moerman E, Eeckhoute J, Formstecher P, Laine B.

J Mol Med. 2002 Jul;80(7):423-30. Epub 2002 May 8.PMID: 12110948 [PubMed - indexed for MEDLINE]Related articles

HNF1alpha controls renal glucose reabsorption in mouse and man.

Pontoglio M, Prié D, Cheret C, Doyen A, Leroy C, Froguel P, Velho G, Yaniv M, Friedlander G.

EMBO Rep. 2000 Oct;1(4):359-65.PMID: 11269503 [PubMed - indexed for MEDLINE]Related articlesFree article

Etiology of early-onset type 2 diabetes in Indians: islet autoimmunity and mutations in hepatocyte nuclear factor 1alpha and mitochondrial gene.

Sahu RP, Aggarwal A, Zaidi G, Shah A, Modi K, Kongara S, Aggarwal S, Talwar S, Chu S, Bhatia V, Bhatia E.

J Clin Endocrinol Metab. 2007 Jul;92(7):2462-7. Epub 2007 Apr 17.PMID: 17440016 [PubMed - indexed for MEDLINE]Related articlesFree article