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    Results: 1 to 20 of 427

    1.

    Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.

    Marzban L, Rhodes CJ, Steiner DF, Haataja L, Halban PA, Verchere CB.

    Diabetes. 2006 Aug;55(8):2192-201.PMID: 16873681 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.

    Marzban L, Trigo-Gonzalez G, Zhu X, Rhodes CJ, Halban PA, Steiner DF, Verchere CB.

    Diabetes. 2004 Jan;53(1):141-8.PMID: 14693708 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site.

    Wang J, Xu J, Finnerty J, Furuta M, Steiner DF, Verchere CB.

    Diabetes. 2001 Mar;50(3):534-9.PMID: 11246872 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation.

    Paulsson JF, Westermark GT.

    Diabetes. 2005 Jul;54(7):2117-25.PMID: 15983213 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells.

    Marzban L, Soukhatcheva G, Verchere CB.

    Endocrinology. 2005 Apr;146(4):1808-17. Epub 2004 Dec 23.PMID: 15618358 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture.

    Marzban L, Tomas A, Becker TC, Rosenberg L, Oberholzer J, Fraser PE, Halban PA, Verchere CB.

    Diabetes. 2008 Nov;57(11):3045-55. Epub 2008 Aug 11.PMID: 18694973 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Processing of synthetic pro-islet amyloid polypeptide (proIAPP) 'amylin' by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro.

    Higham CE, Hull RL, Lawrie L, Shennan KI, Morris JF, Birch NP, Docherty K, Clark A.

    Eur J Biochem. 2000 Aug;267(16):4998-5004.PMID: 10931181 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Processing of pro-islet amyloid polypeptide (proIAPP) by the prohormone convertase PC2.

    Badman MK, Shennan KI, Jermany JL, Docherty K, Clark A.

    FEBS Lett. 1996 Jan 15;378(3):227-31.PMID: 8557106 [PubMed - indexed for MEDLINE]Related articles

    9.

    Processing of pro-islet amyloid polypeptide in the constitutive and regulated secretory pathways of beta cells.

    Marzban L, Trigo-Gonzalez G, Verchere CB.

    Mol Endocrinol. 2005 Aug;19(8):2154-63. Epub 2005 Mar 31.PMID: 15802374 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets.

    Paulsson JF, Andersson A, Westermark P, Westermark GT.

    Diabetologia. 2006 Jun;49(6):1237-46. Epub 2006 Mar 29.PMID: 16570161 [PubMed - indexed for MEDLINE]Related articles

    11.

    Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor.

    Ugleholdt R, Poulsen ML, Holst PJ, Irminger JC, Orskov C, Pedersen J, Rosenkilde MM, Zhu X, Steiner DF, Holst JJ.

    J Biol Chem. 2006 Apr 21;281(16):11050-7. Epub 2006 Feb 13.PMID: 16476726 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Characterization of the heparin binding site in the N-terminus of human pro-islet amyloid polypeptide: implications for amyloid formation.

    Abedini A, Tracz SM, Cho JH, Raleigh DP.

    Biochemistry. 2006 Aug 1;45(30):9228-37.PMID: 16866369 [PubMed - indexed for MEDLINE]Related articles

    13.

    beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

    Andrikopoulos S, Verchere CB, Terauchi Y, Kadowaki T, Kahn SE.

    Diabetes. 2000 Dec;49(12):2056-62.PMID: 11118007 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.

    Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe CG, Butler PC.

    Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1317-24. Epub 2006 Jul 18.PMID: 16849627 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Human islet amyloid polypeptide accumulates at similar sites in islets of transgenic mice and humans.

    de Koning EJ, Höppener JW, Verbeek JS, Oosterwijk C, van Hulst KL, Baker CA, Lips CJ, Morris JF, Clark A.

    Diabetes. 1994 May;43(5):640-4.PMID: 8168639 [PubMed - indexed for MEDLINE]Related articles

    16.

    Proglucagon processing in an islet cell line: effects of PC1 overexpression and PC2 depletion.

    Dhanvantari S, Brubaker PL.

    Endocrinology. 1998 Apr;139(4):1630-7.PMID: 9528943 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis.

    Ritzel RA, Butler PC.

    Diabetes. 2003 Jul;52(7):1701-8.PMID: 12829636 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice.

    Wideman RD, Covey SD, Webb GC, Drucker DJ, Kieffer TJ.

    Diabetes. 2007 Nov;56(11):2744-52. Epub 2007 Aug 13.PMID: 17698597 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro.

    Hull RL, Zraika S, Udayasankar J, Kisilevsky R, Szarek WA, Wight TN, Kahn SE.

    Am J Physiol Cell Physiol. 2007 Nov;293(5):C1586-93. Epub 2007 Sep 5.PMID: 17804609 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Altered proglucagon processing in an alpha-cell line derived from prohormone convertase 2 null mouse islets.

    Webb GC, Dey A, Wang J, Stein J, Milewski M, Steiner DF.

    J Biol Chem. 2004 Jul 23;279(30):31068-75. Epub 2004 May 13.PMID: 15143067 [PubMed - indexed for MEDLINE]Related articlesFree article

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