PubMed

Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.

Dentin R, Benhamed F, Hainault I, Fauveau V, Foufelle F, Dyck JR, Girard J, Postic C.

Diabetes. 2006 Aug;55(8):2159-70.PMID: 16873678 [PubMed - indexed for MEDLINE]Related articlesFree article

Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice.

Iizuka K, Miller B, Uyeda K.

Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E358-64. Epub 2006 May 16.PMID: 16705063 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of ChREBP in hepatic steatosis and insulin resistance.

Denechaud PD, Dentin R, Girard J, Postic C.

FEBS Lett. 2008 Jan 9;582(1):68-73. Epub 2007 Aug 14. Review.PMID: 17716660 [PubMed - indexed for MEDLINE]Related articles

ChREBP, a transcriptional regulator of glucose and lipid metabolism.

Postic C, Dentin R, Denechaud PD, Girard J.

Annu Rev Nutr. 2007;27:179-92. Review.PMID: 17428181 [PubMed - indexed for MEDLINE]Related articles

Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes.

Matsusue K, Haluzik M, Lambert G, Yim SH, Gavrilova O, Ward JM, Brewer B Jr, Reitman ML, Gonzalez FJ.

J Clin Invest. 2003 Mar;111(5):737-47.PMID: 12618528 [PubMed - indexed for MEDLINE]Related articlesFree article

[Can the hyperactivity of lipogenesis cause hepatic steatosis? A role for ChREBP]

Robichon C, Girard J, Postic C.

Med Sci (Paris). 2008 Oct;24(10):841-6. Review. French. PMID: 18950580 [PubMed - indexed for MEDLINE]Related articles

ChREBP: a glucose-activated transcription factor involved in the development of metabolic syndrome.

Iizuka K, Horikawa Y.

Endocr J. 2008 Aug;55(4):617-24. Epub 2008 May 19. Review.PMID: 18490833 [PubMed - indexed for MEDLINE]Related articlesFree article

Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice.

Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W, Liu Y.

Hepatology. 2009 Apr;49(4):1166-75.PMID: 19177596 [PubMed - indexed for MEDLINE]Related articles

Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.

Yahagi N, Shimano H, Hasty AH, Matsuzaka T, Ide T, Yoshikawa T, Amemiya-Kudo M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N.

J Biol Chem. 2002 May 31;277(22):19353-7. Epub 2002 Mar 28.PMID: 11923308 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice.

Matsusue K, Gavrilova O, Lambert G, Brewer HB Jr, Ward JM, Inoue Y, LeRoith D, Gonzalez FJ.

Mol Endocrinol. 2004 Nov;18(11):2751-64. Epub 2004 Aug 19.PMID: 15319454 [PubMed - indexed for MEDLINE]Related articlesFree article

Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.

Sekiya M, Yahagi N, Matsuzaka T, Najima Y, Nakakuki M, Nagai R, Ishibashi S, Osuga J, Yamada N, Shimano H.

Hepatology. 2003 Dec;38(6):1529-39.PMID: 14647064 [PubMed - indexed for MEDLINE]Related articles

Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression.

Dentin R, Pégorier JP, Benhamed F, Foufelle F, Ferré P, Fauveau V, Magnuson MA, Girard J, Postic C.

J Biol Chem. 2004 May 7;279(19):20314-26. Epub 2004 Feb 25.PMID: 14985368 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered expression of transcription factors and genes regulating lipogenesis in liver and adipose tissue of mice with high fat diet-induced obesity and nonalcoholic fatty liver disease.

Morgan K, Uyuni A, Nandgiri G, Mao L, Castaneda L, Kathirvel E, French SW, Morgan TR.

Eur J Gastroenterol Hepatol. 2008 Sep;20(9):843-54.PMID: 18794597 [PubMed - indexed for MEDLINE]Related articles

Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis.

Zhang YL, Hernandez-Ono A, Siri P, Weisberg S, Conlon D, Graham MJ, Crooke RM, Huang LS, Ginsberg HN.

J Biol Chem. 2006 Dec 8;281(49):37603-15. Epub 2006 Sep 12.PMID: 16971390 [PubMed - indexed for MEDLINE]Related articlesFree article

Improvement of insulin sensitivity after peroxisome proliferator-activated receptor-alpha agonist treatment is accompanied by paradoxical increase of circulating resistin levels.

Haluzik MM, Lacinova Z, Dolinkova M, Haluzikova D, Housa D, Horinek A, Vernerova Z, Kumstyrova T, Haluzik M.

Endocrinology. 2006 Sep;147(9):4517-24. Epub 2006 Jun 1.PMID: 16740970 [PubMed - indexed for MEDLINE]Related articlesFree article

The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice.

Cariou B, van Harmelen K, Duran-Sandoval D, van Dijk TH, Grefhorst A, Abdelkarim M, Caron S, Torpier G, Fruchart JC, Gonzalez FJ, Kuipers F, Staels B.

J Biol Chem. 2006 Apr 21;281(16):11039-49. Epub 2006 Jan 30.PMID: 16446356 [PubMed - indexed for MEDLINE]Related articlesFree article

Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice.

Memon RA, Tecott LH, Nonogaki K, Beigneux A, Moser AH, Grunfeld C, Feingold KR.

Endocrinology. 2000 Nov;141(11):4021-31.PMID: 11089532 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3.

Gao H, Bryzgalova G, Hedman E, Khan A, Efendic S, Gustafsson JA, Dahlman-Wright K.

Mol Endocrinol. 2006 Jun;20(6):1287-99. Epub 2006 Apr 20.PMID: 16627594 [PubMed - indexed for MEDLINE]Related articlesFree article

WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice.

Chou CJ, Haluzik M, Gregory C, Dietz KR, Vinson C, Gavrilova O, Reitman ML.

J Biol Chem. 2002 Jul 5;277(27):24484-9. Epub 2002 May 6.PMID: 11994294 [PubMed - indexed for MEDLINE]Related articlesFree article

Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation.

Li JZ, Ye J, Xue B, Qi J, Zhang J, Zhou Z, Li Q, Wen Z, Li P.

Diabetes. 2007 Oct;56(10):2523-32. Epub 2007 Jul 23.PMID: 17646209 [PubMed - indexed for MEDLINE]Related articlesFree article