PubMed

The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells.

Shapira M, Kakiashvili E, Rosenberg T, Hershko DD.

Breast Cancer Res. 2006;8(4):R46.PMID: 16859513 [PubMed - indexed for MEDLINE]Related articlesFree article

The expression of the ubiquitin ligase subunit Cks1 in human breast cancer.

Slotky M, Shapira M, Ben-Izhak O, Linn S, Futerman B, Tsalic M, Hershko DD.

Breast Cancer Res. 2005;7(5):R737-44. Epub 2005 Jul 19.PMID: 16168119 [PubMed - indexed for MEDLINE]Related articlesFree article

EGCG stabilizes p27kip1 in E2-stimulated MCF-7 cells through down-regulation of the Skp2 protein.

Huang HC, Way TD, Lin CL, Lin JK.

Endocrinology. 2008 Dec;149(12):5972-83. Epub 2008 Aug 21.PMID: 18719023 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of doxorubicin treatment on cell cycle arrest and Skp2 expression in breast cancer cells.

Bar-On O, Shapira M, Hershko DD.

Anticancer Drugs. 2007 Nov;18(10):1113-21.PMID: 17893511 [PubMed - indexed for MEDLINE]Related articles

p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase.

Li P, Li C, Zhao X, Zhang X, Nicosia SV, Bai W.

J Biol Chem. 2004 Jun 11;279(24):25260-7. Epub 2004 Apr 9.PMID: 15075339 [PubMed - indexed for MEDLINE]Related articlesFree article

The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells.

Lu L, Schulz H, Wolf DA.

BMC Cell Biol. 2002 Aug 20;3:22. Epub 2002 Aug 20.PMID: 12188931 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.

Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M.

Nature. 2004 Mar 11;428(6979):190-3.PMID: 15014502 [PubMed - indexed for MEDLINE]Related articles

Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas.

Lwin T, Hazlehurst LA, Dessureault S, Lai R, Bai W, Sotomayor E, Moscinski LC, Dalton WS, Tao J.

Blood. 2007 Sep 1;110(5):1631-8. Epub 2007 May 14.PMID: 17502456 [PubMed - indexed for MEDLINE]Related articlesFree article

Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway.

Foster JS, Fernando RI, Ishida N, Nakayama KI, Wimalasena J.

J Biol Chem. 2003 Oct 17;278(42):41355-66. Epub 2003 Aug 6.PMID: 12904306 [PubMed - indexed for MEDLINE]Related articlesFree article

Inverse correlation between expression levels of p27 and the ubiquitin ligase subunit Skp2 in early esophageal squamous cell carcinoma.

Fukuchi M, Masuda N, Nakajima M, Fukai Y, Miyazaki T, Kato H, Kuwano H.

Anticancer Res. 2004 Mar-Apr;24(2B):777-83.PMID: 15161026 [PubMed - indexed for MEDLINE]Related articles

Down-regulation of Skp2 is correlated with p27-associated cell cycle arrest induced by phenylacetate in human prostate cancer cells.

Shibahara T, Onishi T, Franco OE, Arima K, Sugimura Y.

Anticancer Res. 2005 May-Jun;25(3B):1881-8.PMID: 16158921 [PubMed - indexed for MEDLINE]Related articles

Cdh1-anaphase-promoting complex targets Skp2 for destruction in transforming growth factor beta-induced growth inhibition.

Liu W, Wu G, Li W, Lobur D, Wan Y.

Mol Cell Biol. 2007 Apr;27(8):2967-79. Epub 2007 Feb 5.PMID: 17283060 [PubMed - indexed for MEDLINE]Related articlesFree article

SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis.

Calvisi DF, Ladu S, Pinna F, Frau M, Tomasi ML, Sini M, Simile MM, Bonelli P, Muroni MR, Seddaiu MA, Lim DS, Feo F, Pascale RM.

Gastroenterology. 2009 Nov;137(5):1816-26.e1-10. Epub 2009 Aug 15.PMID: 19686743 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells.

Lu Y, Zi X, Pollak M.

Int J Cancer. 2004 Jan 20;108(3):334-41.PMID: 14648698 [PubMed - indexed for MEDLINE]Related articles

Cyclin D3 is down-regulated by rapamycin in HER-2-overexpressing breast cancer cells.

García-Morales P, Hernando E, Carrasco-García E, Menéndez-Gutierrez MP, Saceda M, Martínez-Lacaci I.

Mol Cancer Ther. 2006 Sep;5(9):2172-81.PMID: 16985050 [PubMed - indexed for MEDLINE]Related articlesFree article

Skp2 regulates G2/M progression in a p53-dependent manner.

Hu R, Aplin AE.

Mol Biol Cell. 2008 Nov;19(11):4602-10. Epub 2008 Aug 20.PMID: 18716061 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis.

Fujita T, Liu W, Doihara H, Wan Y.

Am J Pathol. 2008 Jul;173(1):217-28. Epub 2008 Jun 5.PMID: 18535175 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cells.

Bhatt KV, Hu R, Spofford LS, Aplin AE.

Oncogene. 2007 Feb 15;26(7):1056-66. Epub 2006 Aug 21.PMID: 16924241 [PubMed - indexed for MEDLINE]Related articles

Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas.

Hershko D, Bornstein G, Ben-Izhak O, Carrano A, Pagano M, Krausz MM, Hershko A.

Cancer. 2001 May 1;91(9):1745-51.PMID: 11335900 [PubMed - indexed for MEDLINE]Related articlesFree article

Skp2-mediated p27(Kip1) degradation during S/G2 phase progression of adipocyte hyperplasia.

Auld CA, Fernandes KM, Morrison RF.

J Cell Physiol. 2007 Apr;211(1):101-11.PMID: 17096381 [PubMed - indexed for MEDLINE]Related articles